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ADME and Translational Pharmacokinetics/Pharmacodynamics of Therapeutic Proteins : Applications in Drug

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Pharmaceutical researchers from the US, Europe, and Asia offer 27 chapters on the ADME (absorption, distribution, metabolism, and excretion) and translational pharmacokinetics/pharmacodynamics of therapeutic proteins, particularly monoclonal proteins. They report on ADME research and small molecule drugs; the applications of protein engineering to therapeutic proteins and antibodies; protein engineering to influence ADME, pharmacokinetics, and efficacy; antibody-derived proteins and proteins with novel scaffolds; antibody-drug conjugates; the role of the lymphatic system in subcutaneous absorption of therapeutic proteins; biodistribution; the prediction of human pharmacokinetics for protein-based biologic therapeutics; fixed dosing vs. body-size-based dosing; the impact of diseases, comorbidity, and target physiology on ADME, pharmacokinetics, and pharmacodynamics; and immunogenicity. Others discuss mechanistic physiologically based pharmacokinetic models in the development of therapeutic monoclonal antibodies; integrated quantitation of biotherapeutic drug-target binding, biomarkers, and clinical response to support rational dose regimen selection; target-driven pharmacokinetics; tumor and brain effect site pharmacokinetics; molecular pathology techniques in the preclinical development of therapeutic biologics; labeling and imaging techniques for quantification; how knowledge of ADME of therapeutic proteins in adults facilitates pediatric development; liquid chromatography mass spectrometry vs. immune-based bioanalytical methods in quantitation; biosimilar development; vaccines; drug development strategies; clinical pharmacology in the development of biologics; a case study of the nonclinical ADME and pharmacokinetics/pharmacodynamics of an antibody-drug conjugate; and the use of pharmacokinetics/pharmacodynamics knowledge in guiding bispecific biologics research and development. Annotation ©2016 Ringgold, Inc., Portland, OR (
Number of Pages: 448
Genre: Medical, Science
Sub-Genre: Life Sciences / Biochemistry, Pharmacology
Format: Hardcover
Publisher: John Wiley & Sons Inc
Language: English
Street Date: December 2, 2015
TCIN: 50505425
UPC: 9781118898642
Item Number (DPCI): 248-07-6758

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