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Aptamers Ligands : Powerful Tools from Molecular Evolution - (Hardcover)
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The Aptamers Ligands: Powerful Tools from Molecular Evolution discusses these short, single strand oligonucleotides that can fold in a three-dimensional conformation and how they can provide a precise molecular recognition of a given target. These nucleic acid based ligands are identified from large naive combinatorial oligonucleotide libraries using a well-established technology called SELEX (systematic evolution of ligands by exponential enrichment). This approach inspired from the natural evolution concept where an expected evolutionary pressure allows the selection of ligands with very specific properties that can meet specification requirements unobtainable for antibodies or derived ligands.
Aptamers can be extremely specific towards their target molecule with high selectivity and proper affinity dissociation constants. Moreover, they can be selected to recognize a high diversity of molecules, from very small compounds, to large macromolecules, such as proteins.
- Provides the molecular evolution of aptamers
- Includes a technological history on the subject
- Presents analytic and purification applications