Vampire Mitchell (Aidan Turner), werewolf George (Russell Tovey), and ghost Annie (Lenora Crichlow) encounter new enemies in their fight to lead something close to normal lives. It's tough being supernatural. Mitchell's romance with a feisty doctor is disrupted by a vampire community in disarray. George's relationship with a new girlfriend is undermined by an uncontrollable twist in his werewolf existence. Annie has a brutal reminder that life as a spirit is full of challenges. All three are threatened by CenSSA, a religious organization committed to the destruction or conversion of supernatural freaks operated by the mysterious Professor Jaggat and the sinister, cold-hearted Kemp. Just when your inner demons might be conquered, it's the outer demons who won't go away.