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C-Furanosides : Synthesis and Stereochemistry (Paperback) (Peter Goekjian & Arnaud Haudrechy & Boudjema

C-Furanosides : Synthesis and Stereochemistry (Paperback) (Peter Goekjian & Arnaud Haudrechy & Boudjema - image 1 of 1

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Carbon analogs of carbohydrates, dubbed C-glycosides, have remained an important and interesting class of mimetics, be it in natural product synthesis, for pharmacological applications, as conformational probes, or for biological studies. C-Furanosides: Synthesis and Stereochemistry provides a much-needed overview of synthetic and stereochemical principles for C-furanosides: analogs of a 5-membered ring carbohydrate glycoside (furanoside), in which the anomeric oxygen has been replaced with a carbon.

While our understanding of conformational behavior and of stereoselective synthesis in 6-membered ring compounds is quite good, our ability to predict the conformation of 5-membered ring compounds, or to predict the stereochemical outcome of a given reaction, remains anecdotal. Through a comprehensive review of literature approaches to the different C-furanoside stereoisomers, as well as an interpretation of the outcome in terms of a reasonable number of stereochemical models, C-Furanosides: Synthesis and Stereochemistry enables the reader to determine the best approach to a particular C-glycoside compound, and also hopes to provide a certain level of rationalization and predictability for the synthesis of new systems.

  • Provides a comprehensive review of the growing literature in C-furanosides
  • Enables readers to choose the most convenient approach to access a defined target in natural products synthesis or pharmacology and make reasonable predictions for the stereochemical outcome in unpublished cases
  • Explores the various rational models for stereochemical analysis of furanoside reactivity, with a clear distinction made between physical chemical mechanisms and stereochemical models
Number of Pages: 771
Genre: Science
Format: Paperback
Publisher: Elsevier Science Ltd
Author: Peter Goekjian & Arnaud Haudrechy & Boudjema Menhour & Claire Coiffier
Language: English
Street Date: November 30, 2017
TCIN: 52026083
UPC: 9780128037393
Item Number (DPCI): 248-39-8710
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