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Chromatography : Principles and Instrumentation (Hardcover) (Mark F. Vitha)
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This book is a dedicated, focused monograph about the theory, instrumentation, and modern practice of chromatography. In every chapter you will find figures and problems designed to help you visualize the important processes and identify the key variables that govern chromatographic separations. Sections about micro-GC separations, two-dimensional liquid chromatography (2D-LC), superficially porous particles, ultra-high performance liquid chromatography (UHPLC), and Orbitrap mass spectrometry ensure that you are introduced to the most recent developments in chromatography. Cases studies related to the analysis of performance-enhancing drugs, deliberate food contamination, and oil analyses with international implications illustrate the range of applications addressed by chromatography.
The book is intended to be used as a textbook in undergraduate courses, and is thus written with this purpose and audience in mind. It is deliberately pedagogical and written in a clear, concise manner to facilitate understanding. Chapter 1 provides an in-depth description of the processes governing chromatography, including a systematic development of band broadening. Chapter 2 focuses on gas chromatography (GC). It introduces the components of GC instruments in the context of the functions they accomplish and discusses the theory behind instrumentation. The final chapter addresses liquid chromatography. It emphasizes reversed-phase liquid chromatography (RPLC) because of its prominence, but you will also find descriptions of all of the common modes of LC, including hydrophilic interaction chromatography. This chapter also discusses topics such as sub-2-mm particles, superficially porous particles, UHPLC, and 2D-LC as part of the mainstream modern practice of LC, preparing readers to operate in modern laboratories.