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Fragment-Based Drug Discovery : Lessons and Outlook (Hardcover) (Wolfgang Jahnke & Hugo Kubinyi & Gerd

Fragment-Based Drug Discovery : Lessons and Outlook (Hardcover) (Wolfgang Jahnke & Hugo Kubinyi & Gerd - image 1 of 1

About this item

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed.

The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

Number of Pages: 500
Genre: Medical
Sub-Genre: Pharmacology
Series Title: Methods and Principles in Medicinal Chemistry
Format: Hardcover
Publisher: John Wiley & Sons Inc
Author: Wolfgang Jahnke & Hugo Kubinyi & Gerd Folkers
Language: English
Street Date: February 8, 2016
TCIN: 50548717
UPC: 9783527337750
Item Number (DPCI): 248-08-2372
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