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Making Drugs from Fragments : Starting Simple and Keeping It Simple (Paperback) (Vicki Nienaber)
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As a method that offers great benefits in terms of economic viability, rapidity of results and good success rates, fragment-based drug design has quickly been embraced by the drug discovery community. Combining strong coverage of foundational knowledge with expert tips and techniques, Starting simple and keeping it simple: How to make drugs from fragments is designed to provoke new ideas and discussion amongst seasoned professionals, whilst helping those in non-scientific roles to evaluate the opportunities and benefits of implementing fragment-based design at their organizations.
Beginning with an introduction to the rules and metrics of fragment-based lead discovery and how to assess their usefulness, the book then reviews methods for prioritizing targets, designing fragment libraries and the potential for combining fragment-based methods with high-throughput screening for the benefit of both. Taking a practical approach to finding fragments is also discussed, followed by fragments finding their own binding sites. Methods for taking simple fragments and optimizing them to simple drug-like candidates are reviewed, followed by a practical overview of why fragments might not develop and optimize as expected. Readers will also learn how parallel processing can help streamline the fragment-to-lead process. The book concludes by asking if the processes and accumulated data can be simplified and standardized to increase the efficiency of fragment-based drug discovery.
Under the expert guidance of its pioneering author, Starting simple and keeping it simple: How to Make Drugs From Fragments is both a practical tool for chemists and an accessible guide for their managers to the best ways to implement and optimize fragment-based drug design in their work.
- Discusses current methods and common issues associated with implementing and optimizing FBLD, supported by practical examples from industry experts
- Draws on the author’s experience bridging academia and industry to present the key practical knowledge needed by relative new-comers to the technology in an accessible way
- Reviews the need for standardization and highlights implementation options