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Mathematical Modelling of Chromosome Replication and Replicative Stress (Reprint) (Paperback) (Jens

Mathematical Modelling of Chromosome Replication and Replicative Stress (Reprint) (Paperback) (Jens - image 1 of 1

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DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive.

This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?.

A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.

Edition: Reprint
Genre: Science
Series Title: Springer Theses
Format: Paperback
Publisher: Springer Verlag
Author: Jens Karschau
Language: English
Street Date: September 30, 2016
TCIN: 51746257
UPC: 9783319362823
Item Number (DPCI): 248-31-0052

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