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Mechanisms of DNA Recombination and Genome Rearrangements : Intersection Between Homologous

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Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair, Volume 601, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.

Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination. The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts.

  • contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability
  • documents cutting edge methods
Number of Pages: 434
Genre: Science
Series Title: Methods in Enzymology
Format: Hardcover
Publisher: Elsevier Science Ltd
Language: English
Street Date: March 3, 2018
TCIN: 53119211
UPC: 9780128139790
Item Number (DPCI): 248-54-7220
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