This volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules. The twenty-one chapters, all authored by internationally-renowned experts, open with an introduction contextualizing microRNA manipulation within today’s initiatives towards precision medicine. The following chapters explore the clinical role of microRNAs in the diagnosis and treatment of metabolic and cardiovascular disorders, focusing on mitochondrial fitness, arterial hypertension, cardiovascular remodeling, cerebrovascular disease, pulmonary hypertension, diabetic kidney disease, and kidney transplantation. The subsequent chapters discuss the importance of microRNAs in the wound healing process and in skin disease, in the pathogenesis of allergy, in human ovulation, and in infection. The book concludes with chapters which outline the emerging role of microRNAS in doping and detail microRNA profiling.
microRNA: Clinical Science is an ideal companion to both microRNA: Clinical Evidence andmicroRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.
The book provides the most updated and comprehensive microRNA (miRNA) clinical evidence from worldwide renowned scientists. It is now known that miRNAs can suppress the expression of key genes involved in several cellular processes, including cell differentiation, development, migration, proliferation, and apoptosis. This dedicated work focuses on the medical evidence associated with the biological miRNA machinery at the clinical level. Chapters are devoted to topics including microRNA and: personalized medicine, diabetic kidney disease, multiple sclerosis, Parkinson's Disease, heart failure, colorectal cancer, Alzheimer's disease and many more.microRNA: Medical Evidence
complements the basic science covered in the companion volumemicroRNA:Basic Biology
as well as the cancer-specific research in microRNA: Cancer
. Taken together, these three volumes provide essential information for physicians who want to gain a better understanding of this emerging field in the clinical scenario (both as diagnostic marker and for therapeutic opportunities), as well as for scientists, biologists, geneticists, and biomedical researchers investigating the role of these molecules in their specific research projects. It is also useful for advanced graduate students and postdoctoral fellows who want to learn more about innovative and essential mechanisms of gene regulation.
Sub-Genre: Molecular Physics, Life Sciences / Cytology, Life Sciences / Biology / Molecular Biology
Series Title: Advances in Experimental Medicine and Biology
Publisher: Springer Verlag
Street Date: December 21, 2015
Item Number (DPCI): 247-52-1939