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Molecular Oncology : Underlying Mechanisms and Translational Advancements (Hardcover)
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Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasing sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer and it is now know that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, loss of apoptosis are contributory in cancer development, progression and development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy.
Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.