Loading, please wait...
:

product description page

Nonclinical Drug Administration : Formulations, Routes and Regimens for Solving Drug Delivery Problems

Nonclinical Drug Administration : Formulations, Routes and Regimens for Solving Drug Delivery Problems - image 1 of 1

About this item

If we will ever achieve Paul Ehrlich’s "magic bullet," that is, a molecule which goes with high selectivity to the therapeutic target site, does what it needs to do, and is subsequently cleared from the body, the practice of safety assessment will have to change. Nonclinical Drug Administration: Formulations, Routes and Regimens for Solving Drug Delivery Problems in Animal Model Systems seeks to address a trio of objectives that, though separate, are linked and central to biomedical science and, ultimately, medicine. Rather seeing these as separate "silos," those working in nonclinical safety assessment will have to view these three in an integrated manner and to regularly and thoughtfully incorporate new information and technology.

The trio of objectives this book explores are: first, to present how to deliver more of a drug product systemically to facilitate the regulatory need for evaluating safety and efficacy in animal species (at elevated exposure levels) prior to advancing the drug to human testing; second is to achieve better tolerance to therapeutics administration in test animals and humans which achieves objectives 1 and 3; and third, to explore ways to improve on therapeutic target receptor delivery performance, therefore improving both clinical pharmacodynamics bioavailability and specificity.

The book’s ten chapters assemble the basic concepts, principles and hypotheses involved in quantitative receptor and chronological organism interaction dynamics central to the successful development of new therapeutics which depend on systemic administration to achieve desired therapeutic goals and in so doing avoid outcomes which limit, marginalize, or preclude the therapeutic use of so many molecules.

Number of Pages: 406
Genre: Medical
Format: Hardcover
Publisher: Taylor & Francis
Author: Shayne C. Gad & Charles B. Spainhour
Language: English
Street Date: August 25, 2017
TCIN: 53124570
UPC: 9781466502536
Item Number (DPCI): 248-54-9507
If the item details above aren’t accurate or complete, we want to know about it. Report incorrect product info.
$169.95
Shipping
In stock - free standard shipping with REDcard
Not in stores

Ratings & reviews

Prices, promotions, styles and availability may vary by store & online. See our price match guarantee. See how a store is chosen for you.


*See offer details. Restrictions apply. Pricing, promotions and availability may vary by location and at Target.com.