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P53 Protein : From Cell Regulation to Cancer (Hardcover)

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During recent years, the study of the p53 protein has shifted from the basic science of mutations, to the role of mutated proteins in human cancer. Reflecting that shift, the papers here consider the structure and functions of the p53 protein, the regulation of cellular functions by the p53 protein, p53 mutations in human cancers, and clinical manifestations of the p53 pathway in human cancers. Among the topics are the transactivation domain of the p53 protein, the cell-cycle arrest and apoptotic functions of p53 in tumor initiation and progression, p53 and the carcinogenicity of chronic inflammation, p53 as an effector or inhibitor of therapy response, and exploiting the p53 pathway for therapy. Annotation ©2016 Ringgold, Inc., Portland, OR (protoview.com)
Number of Pages: 504
Genre: Science, Medical
Sub-Genre: Life Sciences / Biochemistry, Oncology, Life Sciences / Biology / Molecular Biology
Series Title: Cold Spring Harbor Perspectives in Medicine
Format: Hardcover
Publisher: Cold Spring Harbor Laboratory Pr
Language: English
Street Date: March 31, 2016
TCIN: 50777783
UPC: 9781621821335
Item Number (DPCI): 248-10-9442
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