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Phenotypes and Genotypes : The Search for Influential Genes (Hardcover) (Florian Frommlet & Malgorzata

Phenotypes and Genotypes : The Search for Influential Genes (Hardcover) (Florian Frommlet & Malgorzata - image 1 of 1

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This book presents the methodology of association mapping in experimental populations and genome-wide association studies (GWAS). The main emphasis is placed on methods based on modifications of the Bayesian information criterion, designed specifically to handle multiple testing problems in large-scale genome scans for trait loci (TL). The book is written at the level of a graduate course for bioinformatics students. The first chapter introduces the major concepts of quantitative trait loci (QTL) mapping. The second chapter discusses the methodology of QTL mapping in experimental populations, with the main emphasis on the related issues of model selection in linear models. The approach is then extended to TL via generalized linear models. Chapter three describes the methods for GWAS and related multiple testing and model selection problems. In both chapters two and three the properties of QTL mapping methods are illustrated with computer simulations and real data analysis.
This book presents the methodology of association mapping in experimental populations and genome-wide association studies (GWAS). The main emphasis is placed on methods based on modifications of the Bayesian information criterion, designed specifically to handle multiple testing problems in large-scale genome scans for trait loci (TL). The book is written at the level of a graduate course for bioinformatics students. The first chapter introduces the major concepts of quantitative trait loci (QTL) mapping. The second chapter discusses the methodology of QTL mapping in experimental populations, with the main emphasis on the related issues of model selection in linear models. The approach is then extended to TL via generalized linear models. Chapter three describes the methods for GWAS and related multiple testing and model selection problems. In both chapters two and three the properties of QTL mapping methods are illustrated with computer simulations and real data analysis.
Number of Pages: 290.0
Genre: Science, Technology
Sub-Genre: Life Sciences / Biology
Series Title: Computational Biology
Format: Hardcover
Publisher: Springer Verlag
Author: Florian Frommlet & Malgorzata Bogdan & David Ramsey
Language: English
Street Date: February 24, 2016
TCIN: 16108174
UPC: 9781447153092
Item Number (DPCI): 247-21-2880

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