product description page

Polyglutamine Disorders - (Hardcover)

$219.99
shipping not available
free order pickup not available
not sold at Manhattan Herald Square

about this item

This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression.

Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17).

The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.



trending health & fitness

  • You Are a Badass: How to Stop Doubting Your Greatness and Start Living an Awesome Life (Paperback) by Jen Sincero

    $12.09

  • Milk and Honey by Rupi Kaur (Paperback)

    $11.99

  • 100 Days to Brave: Devotions for Unlocking Your Most Courage (Hardcover) (Annie F. Downs)

    $12.74

  • Grace, Not Perfection: Embracing Simplicity, Celebrating Joy (Hardcover) (Emily Ley)

    $12.74

  • 52 Lists for Happiness : Weekly Journaling Inspiration for Positivity, Balance, and Joy (Hardcover)

    $11.86

recommended

  • Five finger death pu - Wrong side of heaven/Righteous v1 (CD)

    $12.29

  • Women's Pair of Thieves Sport Socks (Jubilee) - Black 6-10

    $5.98

  • Aveeno® Ultra-Calming® Daily Moisturizer For Sensitive Skin With Broad Spectrum SPF 15 - 4 fl oz

    $13.79

  • Vasilus Bonded Leather 29.5" Barstool Set 2ct - Christopher Knight Home

    $269.59 - $336.79

  • PAW Patrol Adventure Bay Railway Track Set

    $22.49


from the manufacturer


guest reviews

Prices, promotions, styles and availability may vary by store & online. See our price match guarantee. See how a store is chosen for you.