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Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract (Hardcover)
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The grand challenge in improving outcome for patients with either esophageal or gastric adenocarcinoma will be to facilitate early detection. This is predicated on a comprehensive understanding of the evolution of pre-malignant disease. The goal of this volume is to put forward an integrative text on both the current state of translational research on early cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. We aim to emphasize common themes (such as histologic modes of progression and endoscopic treatment modalities) between the distal esophagus and stomach, but also contrast key differences. Marnix Jansen is a histopathologist and clinical researcher who investigates the clonal evolution of esophageal and gastric cancer. Sir Nick Wright is a histopathologist and researcher on epithelial stem cell biology with a career-spanning interest in mechanisms of stem cell evolution and clonal expansion.