:

product description page

Systems Pharmacology and Pharmacodynamics (Hardcover)

Systems Pharmacology and Pharmacodynamics (Hardcover) - image 1 of 1

about this item

While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface that between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.
Genre: Medical
Series Title: Aaps Advances in the Pharmaceutical Sciences
Format: Hardcover
Publisher: Springer Verlag
Language: English
Street Date: December 30, 2016
TCIN: 51555191
UPC: 9783319445328
Item Number (DPCI): 248-24-1161

guest reviews

Prices, promotions, styles and availability may vary by store & online. See our price match guarantee. See how a store is chosen for you.