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Adenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Adenoviruses produced tumors in rodents and the mode of action led to the discovery of tumor supressor genes. Adenoviral vectors can be used as therapies for some kinds of cancers. This book will review the life history and immune responses to adenoviruses as well summarize various therapies implemented with the use of adenoviruses.