Toxicology of Parkinson's Disease (Hardcover) (J. Greenamyre)

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This is a comprehensive book that focuses on the toxicological aspects and non-motor symptoms of PD and addresses its epidemiology, toxicology, and pathogenesis. The book is divided into four sections that cover the fundamentals, molecular mechanisms, toxicant exposures, and modeling. Section 1 begins with an up-to-date overview of PD and its clinical features, treatment, causes, and risk factors. Each chapter covers features and symptoms, like the genetics of PD, dementia and mental health, cardinal features, and risk assessment and includes a review of current medical treatment options and their potential side effects. Section 2 covers unifying molecular mechanisms of PD and explains how various toxicants influence PD. Each chapter focuses on each major disease mechanism, such as mitochondrial dynamics, dopamine oxidation, and neuroinflammation. Section 3 discusses toxicant exposures and PD with chapters on specific classes of compounds and risk assessment to provide a thorough overview of the field. Finally, Section 4 provides examples of animal and cell culture system models of PD to illustrate the discussed methods and topics.