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Following very significant advances, it is now widely recognized that definitive treatment should be considered in patients with stage I non-small cell lung cancer (NSCLC) who have pulmonary dysfunction and/or other co-morbidities. This book is a detailed guide to the evaluation and management of these high-risk patients. It first addresses issues such as pathologic considerations, assessment of co-morbidity and the imaging and staging of NSCLC. Surgical and radiotherapy treatment options, including sublobar resection, minimally invasive surgery, brachytherapy, stereotactic body radiotherapy and proton and charged particle therapy, are then discussed in detail. The role of radiofrequency ablation, salvage local therapy and systemic chemotherapy is also considered.Treatment of High-Risk Early Stage Lung Cancer will be of great interest to radiation and medical oncologists, thoracic surgeons, interventional radiologists and pulmonologists.