Common OTC actives include a low-strength topical steroid (hydrocortisone 1%) for rapid itch relief and skin protectants such as colloidal oatmeal. Other frequently listed ingredients that help soothe and restore the skin barrier are ceramides, glycerin, panthenol (vitamin B5) and various botanical extracts.

Some topical products list a low-strength steroid (hydrocortisone 1%) for itch relief, while steroid-free options rely on protectants and moisturizers—such as colloidal oatmeal and emollients—to soothe skin and support the barrier.

Common formats include lotions, creams and balms for direct application, plus bath-treatment powders designed for whole-body soothing.

Common moisturizing and barrier-supporting ingredients include colloidal oatmeal, ceramides (for example, Ceramide‑1), glycerin, shea butter, panthenol (vitamin B5) and botanical extracts such as licorice root extract.

Descriptions range from very fast itch relief (as quick as five minutes) to 24‑hour hydration, with some balms specifically highlighting overnight or through‑the‑night moisture.

Nighttime eczema items are described as moisturizing balms formulated to lock in hydration overnight and soothe dry, itchy skin.