Your Best Shot - by Ashley Koff Rd (Hardcover)

Book Synopsis

USA Today Bestseller

Why have you struggled with your weight, even when you did "everything right"? The answer isn't willpower or diet, and it's not you. Your Best Shot provides the tools to optimize your weight-health hormones permanently, whether you have never used a GLP-1 medication, are currently using one, or are ready to come off one.

Here's the insight that's reshaping medicine: GLP-1 medications like Ozempic, Wegovy, Mounjaro, and Zepbound work because the body regulates appetite, metabolism, blood sugar, and fat storage through a sophisticated hormonal system. If a medication helped you lose weight or curb cravings, it means your own weight-health hormones weren't functioning at their best. That's not a personal failure. That's biology, and it's fixable--with or without the shot.
Registered dietitian and weight health pioneer Ashley Koff, RD has spent over two decades in clinical practice developing a system that finally addresses why weight loss doesn't often work long-term, and what actually does. The result is an evidence-based, personalized program that meets you exactly where you are.

This is not another weight loss plan. This is your plan.

With Your Best Shot, you will:

• Identify why your weight-health hormone function isn't optimal--and how to fix it
• Personalize the nutrition and lifestyle plan with food, supplement, activity, and sleep guidelines
• Eliminate food noise and decision fatigue by finding out what information to ignore and what to trust
• Navigate the landscape of GLP-1 medications, supplements, and foods
• Build a sustainable reset, because life happens, so your plan needs to adjust with it

Your Best Shot is essential for the millions of people using GLP-1s who want to maximize their results, protect their progress, and build a foundation that lasts long after the medication. It is also the definitive guide for anyone considering coming off GLP-1 therapy who needs a plan that works without it.

If you've struggled with weight, cravings, energy, or body composition, this book was written for you.

Review Quotes

"Ashley is one of the most insightful and trusted nutrition experts I know--there is no one I trust more to train practitioners and guide patients. Your Best Shot puts Ashley's wisdom and knowledge into practice--it's the weight management tool we have been waiting for. " - Tieraona Low Dog, MD, ABOIM, Director, Integrative & Functional Medicine Fellowship, UC-I Susan Samueli Integrative Health Institute

"With growing interest in GLP-1 therapies, it's more important than ever to have a guide you can trust. Your Best Shot is that guide: thorough, precise, compassionate. Ashley Koff RD gives you more than just protocols, she gives you the tools to understand your own body and to choose what works best for you." - Frank Lipman MD, New York Times bestselling author

"A practical, science-based guide to weight health. Ashley Koff RD translates complex hormone science into clear, actionable steps--no gimmicks, just results. She's an expert I trust, and now you can too." - JJ Virgin CNS, CHFS, New York Times bestselling author

"Timely, engaging, and empowering. Overcoming--the challenges of losing weight you don't want, finding health you do--begins with understanding, and you will find that here in delightful abundance." - David L. Katz, MD, MPH, Past President, American College of Lifestyle Medicine;Founder, Diet ID

"After decades of books that treat everyone the same, Your Best Shot emerges as a breakthrough. Ashley Koff RD's new work recognizes that weight health is not one size fits all: it's about weight-health hormones, total nutrition, lifestyle choices, genetics and more. The strategies are evidence-based, actionable, and rooted in real clinical practice. Our patients have benefited tremendously from this approach, and I am thrilled it is now available for everyone's benefit." - Darshan Shah MD, CEO and founder Next Health

Your Best Shot is a revolutionary personalized approach to weight management. Ashley Koff, RD, who is recognized as a leading nutrition innovator, has delivered her unique skills and clinical experience in this important book that provides a successful approach to weight loss in the age of GLP-1 medications. This book is a must-read for anyone trying to make sense of how to manage their weight. - Jefferey Bland, PhD, President of Big Bold Health

In Your Best Shot, Ashley Koff RD gives you the manual and rationale for conducting your n:1 experiment to optimize your metabolic hormones for better overall health. It's a valuable tool for patients and practitioners alike. - Sara Szal MD, bestselling author of Women, Food, and Hormones

With humor, precision, and years of experience Ashley Koff RD serves as your detective pointing out clues to explain the challenge of healthy, sustained weight loss and providing a clear road map for success!

- Victoria Maizes, MD, Founding Executive Director, Andrew Weil Center for Integrative Medicine and author of, Heal Faster: Unlocking Your Rapid Recovery Reflex

Ashley Koff RD is my go-to expert on nutrition and weight health in corporate wellness. In Your Best Shot, she delivers a science-based, easy-to-follow, and compassionate approach to optimizing the body's natural hormone intelligence. You can use her program whether or not you use GLP-1 medications. Ashley helps us shift from chasing quick fixes to building sustainable, hormone-smart habits that truly support mental focus, energy, and well-being. Every leader and organization serious about employee health should have this book on their shelf. - Dr. Romie Mushtaq, Neurologist, Chief Wellness Officer, and bestselling author of The Busy Brain Cure

With the author's introduction from a highly personal perspective and her patient vignettes, Your Best Shot, is a tour-de-force that anyone who cares about their health (most people?) should read. It is also a must-read for the weight loss community, the body image community, the diabetes community, and the nutrition community. The author translates complex biology and clinical science with a clarity that is hard to rival. - Jed W. Fahey, ScD, Nutritional Biochemist, Johns Hopkins University Schools of Medicine and Public Health

Ashley is the most knowledgeable nutritionist that I have ever worked with. She really cares about her clients and is able to work around food intolerances and address different personal nutritional needs. It seems like there is nothing she doesn't know about nutrition.

- Emily Deschanel, actress, producer, mom

For my entire life I had dealt with unpredictable intense chronic gut pain. I met Ashley 15 years ago and she opened my eyes to new way of eating and caring for my overall body. Since then the pain has been eliminated and Ashley has remained my north star for guidance. Her insights have been nothing short of a miracle transformation in my life. - Todd Lieberman, film producer

This book is a powerful step by step guide to precise assessment and discovery leading the reader to identify their next best step to optimal weight health, shot or not. Using clear explanations of the science, case studies and fun ways to achieve real insights, the reader is able to create their own personalized plan for better weight and better health and to continue to iterate on that plan with the tools provided. Your Best Shot is the best resource I have seen for understanding how to create your own personalized plan and next steps, understanding when and how to incorporate "the shot" or not. - Myles Spar, MD, executive medical officer, WndrHlth

In Your Best Shot, Ashley Koff RD reframes the conversation with a refreshing blend of science and personalization. She helps us see GLP-1 medications for what they are: one potential tool, not the whole solution. Through science, patient stories, and her own journey, she shows that weight and metabolic health are built on a foundation of digestion, hydration, nutrition, and lifestyle. This book resonates deeply with my own philosophy of root-cause, whole-person care and is an essential guide for clinicians and patients alike who want lasting, not fleeting, results. - Deanna Minich, PhD, CNS, IFMCP, author, Whole Detox and The Rainbow Diet

Your Best Shot isn't another one-size-fits-all weight loss book--it's the guide you've been waiting for. Ashley reminds you that the foundations to health matter, YOU matter, and the only plan that's going to stick is the one built for your actual life that encourages personalization and adjustments whether you're on a GLP-1 or not. I love how refreshing it is to see weight health explained this way--personal, doable, and real. - Carrie Jones, ND, FABNE, MPH, MSCP

Your Best Shot is both groundbreaking and timeless. This is the weight health system we've needed from an expert we all trust. - Jeffrey Egler MD, Chief Medical Officer, Noom

In Your Best Shot, Ashley Koff RD offers a compassionate, science-based plan that reframes weight health as part of a whole-body ecosystem - shaped by nutrition, digestion, hormones, and lifestyle. This is the essential roadmap we need to support kids and families in building resilience and lasting weight health. - Elisa Song, MD Integrative Pediatrician and Bestselling Author of Healthy Kids, Happy Kids

In Your Best Shot, Ashley Koff RD draws on decades of clinical expertise and scientific insight to reframe the conversation about health and weight in the post-GLP-1 era. Blending practical tools for sustainable eating with clear, no-nonsense guidance that cuts through industry hype, she offers readers a trusted roadmap to understanding their weight, optimizing their wellness, and building a realistic foundation for lasting longevity. - Austin Perlmutter MD, NYT Bestselling Author and Internal Medicine Physician

Your Best Shot offers a clear and empowering perspective on weight management, reminding us that true health is built on a foundation of nourishing, clean food, mindful living, and supporting the body's natural detoxification processes. As an integrative medicine trained physician, I appreciate how this book places GLP-1 therapies in context--as one tool among many--while keeping the focus on holistic, sustainable approaches to overall health. - Aly Cohen MD, Integrative Rheumatologist and bestselling author of DETOXIFY: The Everyday Toxins Harming Your Immune System and How to Defend Against Them

Ashley Koff's Your Best Shot is the antidote to health overwhelm. Instead of one-size-fits-all advice or quick fixes, Koff empowers readers to build a truly personalized plan for long-term metabolic and hormonal balance--whether you're on a GLP-1 medication or not. Practical, science-backed, and refreshingly human, this book helps you understand your body's "ecosystem" and make better--not perfect--choices that last. - Colleen Cutliffe Co-founder CEO of Pendulum Therapeutics

"Ashley Koff RD is my go-to expert on nutrition and weight health in corporate wellness. In Your Best Shot, she delivers a science-based, easy-to-follow, and compassionate approach to optimizing the body's natural hormone intelligence. You can use her program whether or not you use GLP-1 medications. Ashley helps us shift from chasing quick fixes to building sustainable, hormone-smart habits that truly support mental focus, energy, and well-being. Every leader and organization serious about employee health should have this book on their shelf." - Dr. Romie Mushtaq, Neurologist, Chief Wellness Officer, and Best-Selling Author of The Busy Brain Cure