Relieves pain from headache, colds, menstrual cramps, toothaches, muscular aches and arthritis
Excedrin Extra Strength works in 3 ways to relieve headaches
Excedrin Extra Strength caplets contain two pain relievers and a booster for enhanced effect
Headache relief pain reliever available in convenient caplet form
HSA and FSA eligible item. Medicare Advantage OTC (MAOTC) eligible. *OTC benefits and eligible products vary by plan. Check your plan for specific details.
Description
Excedrin Extra Strength Caplets provide clinically proven headache relief fast. Excedrin works in 3 ways to relieve headaches: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect. Available in convenient caplet form, this nonprescription pain relief medicine works as hard as you do, combining aspirin and acetaminophen with caffeine. These active ingredients create a powerful formula with two pain relievers and a booster to offer temporary relief of pain from headaches, colds, premenstrual and menstrual cramps, arthritis, tooth pain and muscle pain. For some, headache pain relief with this Excedrin extra strength pain reliever can start in 15 minutes. Get headache relief fast with Excedrin, the headache expert.
Suggested Age: 12 Years and Up
Health Facts: Contains Acetaminophen
Active Ingredient Strength Value: 250 Milligrams
Product Warning: Contains Acetaminophen
Product Form: Caplet
Primary Active Ingredient: Acetaminophen
Package Quantity: 100
TCIN: 11003626
UPC: 300672000910
Item Number (DPCI): 094-01-0571
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
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Allergy alert: Aspirin may cause a severe allergic reaction which may include:
Allergy alert: Aspirin may cause a severe allergic reaction which may include:: hives, facial swelling ,asthma (wheezing) ,shock.
Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take: more than 8 caplets in 24 hours, which is the maximum daily amount, with other drugs containing acetaminophen,3 or more alcoholic drinks every day while using this product.
Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you: are age 60 or older ,have had stomach ulcers or bleeding problems,take a blood thinning (anticoagulant) or steroid drug,take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) ,have 3 or more alcoholic drinks every day while using this product,take more or for a longer time than directed.
Do not use
Do not use: if you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer,with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
Ask a doctor before use if
Ask a doctor before use if: you have liver disease,stomach bleeding warning applies to you,you have a history of stomach problems, such as heartburn,you have high blood pressure, heart disease, liver cirrhosis, or kidney disease, you are taking a diuretic, you have asthma.
Ask a doctor or pharmacist before use if you are taking
Ask a doctor or pharmacist before use if you are taking: a prescription drug for diabetes, gout, or arthritis ,any other drug, or are under a doctor's care for any serious condition.
Stop use and ask a doctor if
Stop use and ask a doctor if: an allergic reaction occurs. Seek medical help right away,you experience any of the following signs of stomach bleeding: feel faint; vomit blood; have bloody or black stools; have stomach pain that does not get better,ringing in the ears or loss of hearing occurs,painful area is red or swollen,pain gets worse or lasts for more than 10 days,fever gets worse or lasts for more than 3 days,any new symptoms occur. These could be signs of a serious condition.
Directions
Do not use more than directed. Drink a full glass of water with each dose.
Adults and Children 12 Years of Age and Over
Take 2 caplets every 6 hours; not more than 8 caplets in 24 hours
Under 12 Years
Ask a doctor.
Other information
Store at 20 degrees - 25 degrees C (68 degrees - 77 degrees F). Close cap tightly after use. Read all product information before using. Keep this box for important information.
Estimated ship dimensions: 4.09 inches length x 2.16 inches width x 1.92 inches height
Estimated ship weight: 0.21 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
WARNING:Aspirin may cause a severe allergic reaction which may include; hives, facial swelling, asthma[wheezing],shock For more information, go to https://www.p65warnings.ca.gov/
Excedrin Extra Strength is a highly effective pain relief option for headaches, praised for its quick action and long-lasting effects. Many guests appreciate its affordability and easy-to-swallow tablets, making it a convenient choice for on-the-go relief. While some guests find it too strong, the majority recommend it for its reliable performance in alleviating pain. Its compact packaging and child-proof design add to its appeal, making it a staple in many households.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.8
4.8 out of 5 stars
5815 star ratings
4.8 out of 5 stars with 5815 reviews
quality
5.0 out of 5
quality: 5 out of 5
value
4.9 out of 5
value: 4.89 out of 5
100% would recommend
17 recommendations
1 out of 5 stars
16 August, 2026
originally posted on Excederin
Not my cup of tea
[This review was collected as part of a promotion.] This product was too strong for me. For some reason most Excedrin products are. It would be nice if this product was not extra strength. Maybe I’m alt or sensitive to one of the ingredients in this product.
DemetreC
Did you find this review helpful?
5 out of 5 stars
5 August, 2026
originally posted on influenster.com
Headache relief immediately
The best brand and over the counter medicine for headache relief. Excedrin extra strength works quickly and lasts 6-8 hours. Highly recommended this for anyone with occasional headaches.
ElizabethO
Did you find this review helpful?
5 out of 5 stars
31 July, 2026
originally posted on Excederin
Great pain relief
[This review was collected as part of a promotion.] Excedrin extra strength pain relief is great when the headache just won’t let up. It’s a brand I know and trust. I appreciate that it’s affordable as well.
JaymeS
Did you find this review helpful?
5 out of 5 stars
20 June, 2026
originally posted on Excederin
Excedrin Exceeded
[This review was collected as part of a promotion.] Worked well! I hadn’t used excedrin in a while a d was very satisfied with how it kicked in so quickly. Will start buying again definitely reasonably priced.
StephanieS
Did you find this review helpful?
5 out of 5 stars
27 May, 2026
originally posted on Excederin
Great aspirin for headaches
[This review was collected as part of a promotion.] I finally got to use this product and let me tell you it's amazing . I don't use aspirin often and I will use this in the future to help with any headache that comes my way
StevenJ
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5 out of 5 stars
2 May, 2026Verified purchase
(no review title)
It does work for me good. My headache is so bad that working good. I like that pill.
fakhri
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5 out of 5 stars
19 March, 2026
originally posted on Excederin
Works fast with no side effects
[This review was collected as part of a promotion.] I usually take Tylenol for headaches, but started using Excedrin instead once I received it. The combination of acetaminophen, NSAID, and caffeine is powerful & takes away my headaches almost immediately. The instructions were very easy to follow, and the pill was easy to swallow. I had no side effects from taking this medication. It’s easy to carry in your purse or pocket. I have officially converted & won’t be using Tylenol anymore for my headaches.
RaeD
2 guests found this review helpful. Did you?
5 out of 5 stars
13 March, 2026
originally posted on Excederin
Better than ibuprofen
[This review was collected as part of a promotion.] Using this product I notice the difference, I am used to rely on ibuprofen a lot, but this medicine works better. I know that this medicine has helped with all of my stress headaches caused by work or anxieties if life. I woukd definitely recommend to at least give it a try.
ADRIANAG
2 guests found this review helpful. Did you?
5 out of 5 stars
18 February, 2026
originally posted on Excederin
Good pain relief
[This review was collected as part of a promotion.] Very useful bottle of pain relief! I keep this in my bag for when I have a lot of pain and find it fast acting and very useful. My pain goes away quickly and stays away. This bottle gets rid of any headache, body pain, or aches I have and it always comes in handy!
AbbyC
1 guest found this review helpful. Did you?
4 out of 5 stars
27 January, 2026
originally posted on influenster.com
Helpful
I use this product often, couple times a week. It really helps when nothing else will. It takes my horrible headaches away. I would recommend it to anyone who has headaches.
kaseyc84_1490
1 guest found this review helpful. Did you?
5 out of 5 stars
14 January, 2026
originally posted on Excederin
Really works!
[This review was collected as part of a promotion.] I have been taking these for awhile now and it’s been helping me with my headaches. I get very bad headaches, but this really helps them and I’m glad I got them. I highly recommend them.
jenniferd905_1932
1 guest found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommendWould recommend
9 January, 2026Verified purchase
Get it
Love this product. Super fast relief!
CJB
quality
5.0 out of 5
quality: 5 out of 5
value
5.0 out of 5
value: 5 out of 5
Did you find this review helpful?
5 out of 5 stars
5 January, 2026
originally posted on Excederin
Great for body pain
[This review was collected as part of a promotion.] My husband is now a big fan of this product. He has back pain from an old injury. This medication quickly provided relief and he was able to rest and fall asleep easily.
aphop_3409
1 guest found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommendWould recommend
3 January, 2026
Top Headache reliever
Excedrin is a must have in our home.
Justbecause
quality
5.0 out of 5
quality: 5 out of 5
value
5.0 out of 5
value: 5 out of 5
Did you find this review helpful?
5 out of 5 stars
25 December, 2025
originally posted on Excederin
Works great
[This review was collected as part of a promotion.] Top go to for a headache. I love using their for any pain I’m having. Takes care of body aches and headaches within thirty minutes. I’ll always use this product over any other.
katelynnh28_5318
2 guests found this review helpful. Did you?
5 out of 5 stars
13 December, 2025
originally posted on influenster.com
Highly effective
I recommend this for everyone. Highly effective and show effective within 10 to 15 minutes. This is the only medicine that works for me every single time. Capsule shaped so are easier to swallow.
prathap2_1826
2 guests found this review helpful. Did you?
4 out of 5 stars
12 November, 2025
originally posted on Excederin
Great for on the go
[This review was collected as part of a promotion.] Great for headaches, easy to swallow meanwhile very effective when the pain is unbearable. No taste at all so thats great, nice kid proof bottle. Sold everywhere.
aprila83_6321
1 guest found this review helpful. Did you?
5 out of 5 stars
9 November, 2025
originally posted on influenster.com
Only option
Excedrin is the only product that will get rid of a headache for me. I’ve tried so many other options and they always take me back to Excedrin. It kicks in quickly. I buy the bottles with higher caplets counts as then you get the better price per caplet. The packaging is fine.l, not too hard to get open. If you have not tried excedrin yet for a headache, you should.
lindal370_5345
1 guest found this review helpful. Did you?
4 out of 5 stars
6 November, 2025
originally posted on Excederin
Great product
[This review was collected as part of a promotion.] I got to used it when I’m out of the Tylenol and ibuprofen at home. It worked really great in a minutes, my headache got over and make me easy to sleep. It’s not expensive to get.
kimp268_8789
1 guest found this review helpful. Did you?
4 out of 5 stars
4 November, 2025
originally posted on Excederin
worked within 15 mins for me
[This review was collected as part of a promotion.] it worked within 15 mins. feel like more effective than standard pain relievers. good value. nice packaging. recommend using it occasionally rather than daily
