Target New ArrivalsBack to SchoolCollegeClothing, Shoes & AccessoriesHome & DecorKitchen & DiningOutdoor Living & GardenGroceryHousehold EssentialsBabyBeautyPersonal CareSports & OutdoorsHealthWellnessSchool & Office SuppliesToys & GamesElectronics & TechVideo GamesMovies, Music & BooksParty SuppliesGift IdeasGift CardsPetsUlta Beauty at TargetShop by CommunityTarget OpticalDealsClearanceNew ArrivalsBack to SchoolCollegeTop DealsTarget Circle DealsWeekly AdShop Order PickupShop Same Day DeliveryRegistryRedCardTarget CircleFind Stores
Tylenol Cold+Flu Severe Day/Night Caplets - Acetaminophen - 24ct: 325mg Strength - 2 of 4Tylenol Cold+Flu Severe Day/Night Caplets - Acetaminophen - 24ct: 325mg Strength - 3 of 4Tylenol Cold+Flu Severe Day/Night Caplets - Acetaminophen - 24ct: 325mg Strength - 4 of 4
Tylenol Cold+Flu Severe Day/Night Caplets - Acetaminophen - 24ct: 325mg Strength - 1 of 4

Tylenol Cold+Flu Severe Day/Night Caplets - Acetaminophen - 24ct: 325mg Strength

6 Questions
$7.89

In Stock

Eligible for registries and wish lists

Save 5% every day

With Target Circle™ Card

At a glance

About this item

Highlights

  • Tylenol Cold + Flu Severe Day/Night Caplets for cold and flu symptom relief
  • 16 Daytime caplets to reduce fever, loosen phlegm, relieve headache, sore throat
  • 8 Nighttime caplets to reduce fever & relieve runny nose, cough & congestion
  • Each caplet contains 325 mg of acetaminophen, a pain reliever and fever reducer
  • Each caplet contains 5 mg of phenylephrine HCl, a nasal decongestant
  • Each caplet contains 10 mg of dextromethorphan HBr, a cough suppressant
  • Daytime caplets contain guaifenesin 200 mg, an expectorant to help loosen phlegm
  • Nighttime caplets contain 2 mg of chlorpheniramine maleate, an antihistamine

Description

Tylenol Cold + Flu Severe Day/Night Caplets provide temporary relief of cold and flu symptoms. The daytime caplets are formulated to loosen phlegm and temporarily relieve symptoms such as headache, sore throat, nasal congestion and cough. The Nighttime caplets help relieve runny nose and sneezing along with other symptoms such as headache, cough, sore throat, nasal congestion, sinus congestion and pressure. Both multi‑symptom cold medicine formulas also temporarily reduce fever, providing relief when needed. This convenient combo pack contains 24 caplets with 16 Daytime caplets and 8 Nighttime caplets. Each medicine caplet contains 325 mg of acetaminophen, a pain reliever and fever reducer; 5 mg of phenylephrine HCl, a nasal decongestant; and 10 mg of dextromethorphan HBr, a cough suppressant. The Daytime caplets also contain guaifenesin 200 mg, an expectorant to help loosen phlegm (mucus), while the Nighttime caplets contain chlorpheniramine maleate 2 mg, an antihistamine.
Key Ingredients: Tylenol Cold + Flu Severe Caplets (Day) Acetaminophen: Pain reliever/fever reducer Dextromethorphan: Cough suppressant Guaifenesin: Expectorant Phenylephrine: Nasal decongestant
Tylenol Cold + Flu Severe Caplets (Night) Acetaminophen: Pain reliever/fever reducer Chlorpheniramine: Antihistamine Dextromethorphan HBr: Cough suppressant Phenylephrine HCl: Nasal decongestant
How to Use: Tylenol Cold + Flu Severe Caplets (Day): Do not take more than directed (see overdose warning) Adults and children 12 years and over: Take 2 caplets every 4 hours Swallow whole; do not crush, chew or dissolve Do not take more than 10 caplets in 24 hours Children under 12 years: Ask a doctor Tylenol Cold + Flu Severe Caplets (Night): Do not take more than directed (see overdose warning) Adults and children 12 years and over: Take 2 caplets every 4 hours Swallow whole; do not crush, chew or dissolve Do not take more than 10 caplets in 24 hours Children under 12 years: Ask a doctor
Suggested Age: 12 Years and Up
Health Facts: Contains Acetaminophen
Active Ingredient Strength Value: 325 Milligrams
Product Warning: Contains Acetaminophen
Product Form: Caplet
Primary Active Ingredient: Acetaminophen
Package Quantity: 24
Features: Multi-Symptom, Daytime and Nighttime Use
TCIN: 51123909
UPC: 300450550248
Item Number (DPCI): 094-14-0074
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Active ingredients

acetaminophen(325mg), chlorpheniramine maleate(2mg), dextromethorphan hbr(10mg), phenylephrine hcl(5mg). acetaminophen(325mg), dextromethorphan hbr(10mg), guaifenesin(200mg), phenylephrine hci(5mg).

Purpose

Pain Reliever/Fever Reducer, Antihistamine, Cough Suppressant, Nasal Decongestant.. Pain Reliever/Fever Reducer, Cough Suppressant, Expectorant, Nasal Decongestant..

Uses

minor aches and pains, headache, sore throat, nasal congestion, cough, sinus congestion and pressure, sneezing and runny nose, helps clear nasal passages, relieves cough to help you sleep, temporarily reduces fever., minor aches and pains, headache, sore throat, nasal congestion, cough, helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive, temporarily reduces fever.

Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:

Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:: skin reddening,blisters,rash. If a skin reaction occurs, stop use and seek medical help right away.

Do not use

Do not use : with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.,if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.,if you have ever had an allergic reaction to this product or any of its ingredients.

Ask a doctor before use if you have

Ask a doctor before use if you have: liver disease,heart disease,high blood pressure,thyroid disease,diabetes,trouble urinating due to an enlarged prostate gland,persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis or emphysema,cough that occurs with too much phlegm (mucus).

Stop use and ask a doctor if

Stop use and ask a doctor if : nervousness, dizziness, or sleeplessness occur,pain, nasal congestion or cough gets worse or lasts more than 7 days,fever gets worse or lasts more than 3 days,redness or swelling is present,new symptoms occur,cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.

Directions

Do not take more than directed (see overdose warning)., Do not take more than directed (see overdose warning).

Adults and Children 12 Years and Over

Take 2 caplets every 4 hours. Swallow whole; do not crush, chew or dissolve. Do not take more than 10 caplets in 24 hours.

Children Under 12 Years

Ask a doctor.

Adults and Children 12 Years and Over

Take 2 caplets every 4 hours. Swallow whole; do not crush, chew or dissolve. Do not take more than 10 caplets in 24 hours.

Children Under 12 Years

Ask a doctor.

Other information

Store between 20-25 degrees C (68-77 degrees F)., Each caplet contains: sodium 3 mg. Store between 20-25 degrees C (68-77 degrees F).

Inactive ingredients

anhydrous citric acid, carnauba wax, fd&c blue no. 1 aluminum lake, flavor, hypromellose, magnesium stearate, microcrystalline cellulose, modified starch, polyethylene glycol, polysorbate 80, potassium sorbate, powdered cellulose, pregelatinized starch, sodium benzoate, sodium citrate dihydrate, sodium starch glycolate, sucralose, titanium dioxide, carnauba wax, croscarmellose sodium, d&c yellow no. 10 aluminum lake, flavor, hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, sucralose, titanium dioxide

Question or comments?

1-877-895-3665, 1-877-895-3665

Shipping details

Estimated ship dimensions: 4.49 inches length x 2.87 inches width x 0.94 inches height
Estimated ship weight: 0.07 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Q: I don’t see the active ingredient

submitted by GungaDin - 5 months ago

  • A: Hi, the active ingredients are listed on the front label of the product.

    submitted byKenvue - 5 months ago
    Brand expert

Q: Non Drowsy or Drowsy

submitted by Tom - 2 years ago

  • A: Hi there, the product is may occur drowsiness

    submitted byKenvue - 2 years ago
    Brand expert

Q: Do I have to take these with drinking water?

submitted by Benedict - 2 years ago

  • A: Thank you for your question. Yes, you may take these caplets with water. Swallow them whole; do not crush, chew, or dissolve.

    submitted byKenvue - 2 years ago
    Brand expert

Q: What is the dosage for Tylenol? Severe daytime? How often can you take this medication?

submitted by Beda Bollman - 2 years ago

  • A: For an adult and 12 years and older take 2 caplets every 4 hrs. Swallow whole, do not crush, chew or dissolve it. Most importantly do not take more than 10 caplets in 24 hrs. Ask a doctor for a children under 12 years. If you want to know more kindly visit our website. https://www.tylenol.com/products/cold-flu/tylenol-cold-flu-severe-day-night-caplets

    submitted byKenvue - 2 years ago
    Brand expert

Q: Is Tylenol cold+ flu severe safe in pregnancy?

submitted by Aman - 3 years ago

  • A: Thank you so much for your inquiry regarding Tylenol Cold + Flu severe. Please reach out to your health care professional for the best guidance regarding this situation. We always want whats best for you and your family!

    submitted byKenvue - 3 years ago
    Brand expert

Q: Hi I need know if this medicine have NSAIDs

submitted by Caro - 3 years ago

  • A: Our Cold + Flu Severe Day/Night Caplets don't contain NSAID ingredients because they don't reduce inflamation.

    submitted byKenvue - 3 years ago
    Brand expert
See all questions (6)

Additional product information and recommendations

Discover more options

Skip to next section

Frequently bought together

Skip to next section

Guests also viewed

Skip to next section
4.7 out of 5 stars with 1637 reviews
quality: 4.23 out of 5
value: 4.32 out of 5
75% would recommend
44 recommendations
5 out of 5 stars
Thumbs up graphic, would recommend
17 July, 2026

Good deal

Price is cheaper than other stores
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommend
14 June, 2026

Ineffective

This medicine was completely ineffective. It did absolutely nothing- it's almost as if I took a placebo. I will not be wasting my money on this anymore.
Mecmoore
quality: 1 out of 5
value: 1 out of 5
Did you find this review helpful?
1 out of 5 stars
13 May, 2026Verified purchase

(no review title)

Have the flu and this not helped in the slightest :(.
Julia
1 guest found this review helpful. Did you?
5 out of 5 stars
28 April, 2026
originally posted on influenster.com
Image

Great!

Unfortunately, we have to take these every year. But they relieve the symptoms pretty quickly. Easy to take and lasts a while. Everything is easy to read on the box.
SamanthaT
1 guest found this review helpful. Did you?
5 out of 5 stars
13 April, 2026
originally posted on influenster.com
Image

Works fast

These cold and flu really work. They are very effective and convenient,they give value for your money . They both work like magic .Within a couple of days, all my symptoms are gone
KamaraD
Did you find this review helpful?
5 out of 5 stars
8 April, 2026
originally posted on influenster.com
Image

Best medicine to take when sick.

This is my go to medicine when I am sick. This clears me up and takes my stuffy nose away. My pain and discomfort goes away immediately. This is on set.
AnnieM
Did you find this review helpful?
5 out of 5 stars
16 March, 2026
originally posted on tylenol.com
Image

(no review title)

Ohhh my gaurdddda its sorrrrrr goood forrr paiiiinnnnnnn allllso yourrrr coughfs. Def Recomend!!!!!!
had23
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommend
15 March, 2026Verified purchase

Did Not Work

This use to be my go to medication for a cold. Unsure what happened, but it didn’t work at all! I’m very disappointed, this was a waste of money.
Lj
quality: 1 out of 5
value: 1 out of 5
Did you find this review helpful?
1 out of 5 stars
8 March, 2026Verified purchase

Didn't receive this item!!!

Wasn't in the box with everything else so you need to send it or give me a refund!!
starr3648
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommend
1 March, 2026

(no review title)

never received on Feb 26
Chantle
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommend
17 February, 2026Verified purchase

Very good to travel with when you have all allergies two medication.

We have family members that are allergic to many medication’s Tylenol brand is a medication for them. We have been buying the day and night combo pack for many years, we make sure it is in our toiletry kit when we travel. Very effective. Nighttime capsules work very well.
Tina
quality: 5 out of 5
value: 5 out of 5
2 guests found this review helpful. Did you?
4 out of 5 stars
13 February, 2026
originally posted on influenster.com
Image

Relives your flu symptoms

The day time pill helps to alleviate your symptoms and the night time pill helps you get the much needed rest so you can recover. I definitely recommend giving a try if you don’t like the liquid
amandab1140_6079
1 guest found this review helpful. Did you?
1 out of 5 stars
Thumbs down graphic, would not recommend
8 February, 2026Verified purchase

Doesn't work at all for cold and flu symptoms

If I were taking regular Tylenol, I would receive the same alleviation of my symptoms, which include cough, sore throat, and sinus congestion. That is to say, there is no relief. It’s so bad, that I’m wondering how long after the manufacture date it’s actually good. This has a manufacture date of 2023.
Stormcarver
quality: 1 out of 5
value: 1 out of 5
1 guest found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
6 January, 2026Verified purchase

Highly recommend

Helped me feel SO much better quick!
kaebae
quality: 5 out of 5
value: 5 out of 5
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommend
5 January, 2026

Did nothing!

Did not help with coughs or mucus Just a glorified pain reliever
Felicia
quality: 2 out of 5
value: 4 out of 5
Did you find this review helpful?
5 out of 5 stars
4 January, 2026
originally posted on influenster.com
Image

Good for head cold

This medication has been helpful for sinus headaches and pressure. The dosage was clear on the packaging. Easily taken with smooth texture. Would use again.
mimid45_646
1 guest found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommend
31 December, 2025

Magic flu medicine!

This is the best flu medicine I've ever used and I've tried them all. My go to when I'm feeling crappy!
Kelli
quality: 5 out of 5
value: 4 out of 5
2 guests found this review helpful. Did you?
4 out of 5 stars
18 November, 2025Verified purchase

(no review title)

My go too cold /flu medicine
Manny
2 guests found this review helpful. Did you?
5 out of 5 stars
5 November, 2025
originally posted on influenster.com
Image

Amazing

This medicine is the one that helps me the most when I have flu symptoms and muscle pain, the ingredients are similar to any medicine that contains acetaminophen, the savor is good, it is very effective and the cost of the product seems very good to me
yosandrydmoya_9290
2 guests found this review helpful. Did you?
5 out of 5 stars
1 October, 2025
originally posted on influenster.com
Image

Great for the money

The ingredients are normal, there isn't a scent, the packaging was eye-catching, and for the price, it is very effective would buy again. It helped a lot
haleyb328_7856
2 guests found this review helpful. Did you?

Get top deals, latest trends, and more.

Privacy policy
Terms