Adenosine, Cardioprotection and Its Clinical Application - (Developments in Cardiovascular Medicine) (Hardcover)
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About this item
Highlights
- It has been almost 15 years since the fIrst reports appeared indicating that adenosine exerted a .
- Author(s): Robert M Mentzer Jr & Masafumi Kitakaze & James M Downey & Masatsugu Hori
- 239 Pages
- Medical, Cardiology
- Series Name: Developments in Cardiovascular Medicine
Description
Book Synopsis
It has been almost 15 years since the fIrst reports appeared indicating that adenosine exerted a .protective effect in ischemic and reperfused myocardium. Numerous experimental studies have shown that adenosine (both exogenous and endogenous adenosine) delays the onset of ischemic contracture, modulates myocardial metabolism during ischemia, attenuates reversible postischemic ventricular dysfunction (myocardial stunning), and reduces myocardial infarct size. Initial studies on adenosine's cardioprotective effect were based on its ability to stimulate postischemic ATP resynthesis, increase coronary blood flow, and reduce heart rate. Although these actions of adenosine are undoubtedly benefIcial to the ischemic/reperfused heart, it now appears that adenosine's cardioprotective effect may be exclusive of these properties. The immense growth in the number of articles on adenosine cardioprotection in the last several years has been related in large part to the hypothesis that adenosine plays a role in ischemic preconditioning. Ischemic preconditioning is the phenomenon in which a brief period of ischemia (and reperfusion) prior to a more prolonged occlusion reduces myocardial infarct size. This form of myocardial protection has received much interest because ischemic preconditioning has been shown to be the most potent means of reducing infarct size in all animal models thus far tested. In fact prior to studies implicating adenosine's role in ischemic preconditioning, adenosine's infarct reducing effect was not well recognized.Dimensions (Overall): 9.21 Inches (H) x 6.14 Inches (W) x .63 Inches (D)
Weight: 1.19 Pounds
Suggested Age: 22 Years and Up
Number of Pages: 239
Genre: Medical
Sub-Genre: Cardiology
Series Title: Developments in Cardiovascular Medicine
Publisher: Springer
Format: Hardcover
Author: Robert M Mentzer Jr & Masafumi Kitakaze & James M Downey & Masatsugu Hori
Language: English
Street Date: June 30, 1997
TCIN: 1006471776
UPC: 9780792399544
Item Number (DPCI): 247-08-6082
Origin: Made in the USA or Imported
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Shipping details
Estimated ship dimensions: 0.63 inches length x 6.14 inches width x 9.21 inches height
Estimated ship weight: 1.19 pounds
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