Autoimmune Liver Disease - by James Neuberger & Gideon M Hirschfield (Hardcover)

About the Book

"Autoimmune Liver Disease discusses the current understanding about autoimmune liver diseases, focusing on pathogenesis, diagnosis and management. The first section covers the current immunological thinking about autoimmunity and focus on liver diseases with emphasis on the spectrum, significance, use and abuse of autoantibodies and on the implications of the recent advances in the genetics of autoimmunity to allow the reader to place these exciting developments in context. The second section describes four main hepatic autoimmune liver diseases and follows a common format that focuses on aspects of diagnosis and management. Liver transplantation plays an important role in treatment so timing and outcomes are covered: recurrence of autoimmune liver disease is important not only for the recipient and their clinicians but also sheds light on the pathogenesis. De novo autoimmune hepatitis is included in both clinical and scientific chapters. Finally, the authors treat three areas where experience has shown there is uncertainty. The final chapter includes reference to optimal approaches to patient management, including patient empowerment. To ensure that the whole clinical spectrum of autoimmune liver disease is covered, each chapter is jointly covered by contributing authors who are clinicians caring for adult, transitional and paediatric patients"--

Book Synopsis

Ein praxisorientierter Leitfaden zu autoimmunen Lebererkrankungen, Pathogenese, Diagnose und Management.
Autoimmune Liver Disease Management and Clinical Practice erläutert alles Wissenswerte zum aktuellen Forschungsstand autoimmuner Lebererkrankungen und legt dabei den Schwerpunkt auf Diagnose und Behandlung. Nach einer ausführlichen Darstellung der heutigen Erkenntnisse in der Immunologie in Verbindung mit der Autoimmunität der Leber werden die vier wichtigsten autoimmunen Lebererkrankungen bei Erwachsenen und Kindern erläutert, einschließlich Management, Rolle von Lebertransplantationen, erprobte Ansätze des Patientenmanagements und Empowerment-Ansätze.

Die Autoren, Experten des Fachgebiets, untersuchen im Detail autoimmune Lebererkrankungen und geben Kliniker Handreichungen zur Patientenunterstützung. Die folgenden Themenkomplexe werden unter anderem ausführlich behandelt:
- Die vier autoimmunen Lebererkrankungen, deren Diagnose und Behandlungsoptionen.
- Einsatz (und Missbrauch) von Autoantikörpern bei Diagnose und Behandlung.
- Rolle und Zeitpunkt von Lebertransplantationen und die Auswirkung auf wiederkehrende autoimmune Lebererkrankungen und De-novo-Autoimmunhepatitis.
- Optimales Patientenmanagement und patientenbezogene Pflege.

Dieses Referenzwerk zeigt umfassend, im Detail und mit alltäglichem Praxisbezug die jüngsten Entwicklungen beim Management von Lebererkrankungen und richtet sich an Ärzte, Pflegepersonal und Experten im Gesundheitswesen.

From the Back Cover

A practical guide to autoimmune liver diseases through pathogenesis, diagnosis, and management

In Autoimmune Liver Disease: Management and Clinical Practice, practitioners will learn about the current state of autoimmune liver disease and how to focus on their diagnosis and treatment. The four-part book begins with a thorough investigation of current immunological thinking as it relates to the autoimmunity of the liver. It also covers the four major hepatic autoimmune liver diseases in both adults and children, their management and the role of liver transplantation, and learned approaches to patient management and empowerment.

Expert authors in the field have come together to provide a thorough examination of autoimmune liver disease to help support clinicians assisting patients. The text provides an in-depth look at topics including:

• The four major hepatic autoimmune liver diseases, their diagnosis, and potential disease management
• The use (and misuse) of autoantibodies in diagnosis and treatment
• The role and timing of liver transplantation and the impact of recurrent autoimmune liver disease as well as de novo autoimmune hepatitis
• Optimal approaches to managing patients and keeping care personalised

With breadth, depth and current-day relevance, Autoimmune Liver Disease sheds light on recent developments in management of liver disease for practitioners, nurses, and health care professionals.

About the Author

JAMES NEUBERGER studied at Oxford and trained at the Liver Unit, Kings College Hospital, in London. He has researched and written about liver disease and liver transplantation for over 35 years, including editing five books and serving as the editor of Transplantation and associate editor of The Journal of Hepatology. He is currently a consultant physician in the Liver Unit, Queen Elizabeth Hospital, Birmingham, UK.

GIDEON M. HIRSCHFIELD is a clinician-scientist and expert in autoimmune liver disease practice and science. His experience spans many years in transplant Hepatology in North America and the United Kingdom, including numerous published works. He currently has a practice at the University of Toronto, Ontario, Canada.