Preclinical Research in Down Syndrome: Insights for Pathophysiology and Treatments - (Progress in Brain Research) (Hardcover)

Book Synopsis

Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more.

Review Quotes

"It is important to recognize that trisomy 21 does not receive enough attention from the scientific community. This is a unique book that brings to the medical community the vast work still needed to understand trisomy 21 and to improve outcomes of individuals with Down syndrome. The Trisomy 21 Research Society has done an excellent job supporting this publication and Mara Dierssen has achieved her goals well in editing this extremely important contribution." --Doody