Textbook of Clinical Trials - 2nd Edition by David Machin & Simon Day & Sylvan Green (Hardcover)

Book Synopsis

Now published in its Second Edition, the Textbook of Clinical Trials offers detailed coverage of trial methodology in diverse areas of medicine in a single comprehensive volume.

Praise for the First Edition:

"... very useful as an introduction to clinical research, or for those planning specific studies within therapeutic or disease areas." BRITISH JOURNAL OF SURGERY, Vol. 92, No. 2, February 2005

The book's main concept is to describe the impact of clinical trials on the practice of medicine. It separates the information by therapeutic area because the impact of clinical trials, the problems encountered, and the numbers of trials in existence vary tremendously from specialty to specialty. The sections provide a background to the disease area and general clinical trial methodology before concentrating on particular problems experienced in that area. Specific examples are used throughout to address these issues.

The Textbook of Clinical Trials, Second Edition

• Highlights the various ways clinical trials have influenced the practice of medicine in many therapeutic areas
• Describes the challenges posed by those conducting clinical trials over a range of medical specialities and allied fields
• Additional therapeutic areas are included in this Second Edition to fill gaps in the First Edition as the number and complexity of trials increases in this rapidly developing area
• Newly covered or updated in the Second Edition: general surgery, plastic surgery, aesthetic surgery, palliative care, primary care, anaesthesia and pain, transfusion, wound healing, maternal and perinatal health, early termination, organ transplants, ophthalmology, epilepsy, infectious disease, neuro-oncology, adrenal, thyroid and urological cancers, as well as a chapter on the Cochrane network

An invaluable resource for pharmaceutical companies, the Textbook of Clinical Trials, Second Edition appeals to those working in contract research organizations, medical departments and in the area of public health and health science alike.

From the Back Cover

Textbook of Clinical Trials second edition continues the original aim, to highlight the varied ways that clinical trials - particularly randomized controlled trials - have influenced the practice of medicine within different therapeutic areas. It describes the different challenges posed by those conducting clinical trials across a range of medical specialities and allied fields and at the same incorporates the development of clinical trial statistical methodology. The background to each medical speciality is provided, followed by the characteristic problems experienced by trialists in that area. Case studies are used throughout to provide a comprehensive key text in this rapidly expanding area.

This unique way of presenting clinical trial information will make this second edition an essential reference for clinical trialists, whether with administrative, data management and quality, scientific, medical or statistical roles. In addition it will provide a reference for pharmaceutical industry personnel, members of ethics committees and those who work in regulatory departments.

Building on the success of the first edition many new therapeutic areas are included including:

General surgery, plastic surgery, aesthetic surgery palliative care, primary care, anaesthesia and pain, transfusion, wound healing, maternal and perinatal health, early termination, organ transplants, ophthalmology, epilepsy, infectious disease, neuro-oncology, adrenal cancer thyroid cancer urological cancer

About the Author

David Machin, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.

Simon Day, Medicines and Healthcare Products Regulatory Agency, London, UK.

Sylvan Green, Arizona Cancer Center, Tucson, Arizona, USA.