The Dose Makes the Poison - 3rd Edition by Patricia Frank & M Alice Ottoboni (Paperback)

About the Book

Prev. ed., ppublished in 1991, entered under M. Alice Ottoboni.

Book Synopsis

This new edition of a widely-read and highly-acclaimed book broadens the scope of its predecessors from a heavy focus on industrial chemicals as toxicants to include drugs, food additives, cosmetics and other types of compounds that people are exposed to daily. Also new to the 3^rd edition are newer issues-of-the-day such as nanoparticulate toxicants, second hand smoke, food contamination, lead in toys, and others. As such, the book provides the basics of toxicology in easy-to-understand language as well as a fuller understanding of the daily insults to which our bodies are subjected.

From the Back Cover

An introductory guide to the history, concepts, and practice of toxicology

With the advent of serious industrialization in non-Western economies such as China and India, the integrity of our food supply is once again in question and the safety of various consumer products and medicines at risk. Every day, people are exposed to a wide array of chemicals and other potential toxicants--from industrial emissions, the natural environment, drugs, and consumer products. Using broadly accessible language and clear examples, the Third Edition of The Dose Makes the Poison updates its highly acclaimed predecessors and explains the basics and practice of toxicology in easy-to-understand language.

This new edition broadens its scope from a heavy focus on industrial chemicals as toxicants to include drugs, food additives, cosmetics, and other types of compounds that people are exposed to daily. Also new to the Third Edition are recent issues-of-the-day such as bisphenol A, secondhand smoke, food contamination, lead in toys, melamine toxicity to children and pets, and drug recalls. Basic principles of how doses and routes of administration alter toxicity, testing paradigms for drugs and chemicals, and newer technology such as nanoparticles are all addressed and explained. In addition, the book:

• Presents case studies of historical and current interest to illustrate various aspects of toxicology
• Deals with all types of chemicals that we confront every day, including drugs, food additives, vitamins, and others
• Includes an introduction to how chemicals cause harm, the factors that influence toxicity, and the ways that chemicals and drugs are tested to determine their safety

Review Quotes

"This is a refreshing, invigorating as well as eye-opening text, which is reading like an exciting novel - even to a seasoned toxicologist ... An appendix to clarify quantities of pollutants plus an index concludes this most valuable introduction into the science of toxicology for a broad readership." (Toxicology, 2011)

"I recommend this book to anyone who has ever listened to the evening news and wondered how much of the "chemical scare du jour" is hype and how much of it is fact - and to those who might want to understand basic concepts in toxicology and the related areas of study without having to trudge through a gaggle of 1000-page textbooks." (International Journal of Toxicology, 2011)

"Overall, this is a well-written work with wisely chosen and relevant topics. It will be a perfect addition to any science enthusiast's library. Summing Up: Highly recommended. Lower-level undergraduates through professionals/practitioners; general readers." (Choice, 1 September 2011)

"The Dose Makes the Poison is more than just an introduction to toxicology. It is an enjoyable read with lots of interesting stories and one I can thoroughly recommend." (Chemistry & Industry, 25 July 2011)

"There is much to be applauded in this book from its straightforward layout and honesty to its accessibility . . . Many good, and contemporary, examples are provided to deliver greater context for the reader." (The British Toxicology Society Journal, 1 May 2011)

About the Author

Patricia Frank is President of Patricia Frank & Associates, Inc., a consulting firm founded in 1993 that assists companies in the development and registration of human and veterinary pharmaceutical agents. She is a past president of both the American College of Toxicology and the Roundtable of Toxicology Consultants.

M. Alice Ottoboni lectures, writes, and consults in the field of toxicology. As Staff Toxicologist with the California State Department of Public Health for over twenty years, she originated, designed, and performed numerous toxicological studies of environmental factors of importance to public health. She is the author of the previous editions of The Dose Makes the Poison.