General and Molecular Pharmacology - by Francesco Clementi & Guido Fumagalli (Hardcover)

Book Synopsis

With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action - the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics.

- Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students
- Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs
- Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties
- Focuses on structure-function relationships of drug targets - informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development
- Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book

From the Back Cover

Defined by ASPET as the study of the effects of chemical agents of therapeutic value or with the potential toxicity on biological systems, pharmacology is critical to understanding how drugs can correct the biochemical abnormalities responsible for human illness. It is one of the core disciplines students need to master in order to develop effective drugs and therapeutics.

This book, the updated and enhanced English translation of a successful and multi-edition Italian text, covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention mechanisms of drug action - the fundamental basis for proper clinical use - without neglecting drug interactions, general physiological functions, and the toxicological effects of chemical compounds . As opposed to classical pharmacology textbooks, which spend more time detailing medical and therapeutic effects, the authors offer thorough discussion of drug action mechanisms at cell and molecular level and the rules governing drug pharmacokinetics and development.

The target-oriented approach within the text changes the common perception of drugs as chemical entities affecting organisms and highlights the interdisciplinary and dynamic nature of pharmacological research. As such, the book introduces pharmacologists to a more integrated view of their discipline and fosters a holistic approach to the analysis and treatment of diseases - one in which drugs are regarded as critical tools to discover new cell functions, mechanisms, and therapies.

Complementary to the main text, the book has a companion website that builds on the content within the book itself by addressing more specific subjects and methodologies. The site is ideal for readers who have mastered the basic principles and are seeking more in-depth knowledge of detailed topics.

More than just a course text for pharmacology students, this book can also be a key reference and resource for researchers and professionals involved in any aspect of drug development

About the Author

Francesco Clementi is a Professor Emeritus of Pharmacology at the University of Milan. He has been President of several national and international societies and is member of the Accademia dei Lincei, the prestigious Academy of Italian Sciences. He authored over 200 publications dealing with neurotransmitter receptors and co-edited several books on neuropharmacology and cell biology including all four editions of the Italian language version of this book, Farmacologia Generale e Molecolare.

Guido Fumagalli has been the Dean of Faculty Director of the PhD School of Translational Medicine, Vice-Provost for Research, and Vice-Provost for International Affairs at the University of Verona. He has over 80 publications in international journals to his credit along with numerous books on pharmacology and sports science