Losing the Weight Loss Meds - by Holly R Wyatt & James O Hill (Paperback)

Book Synopsis

Innovative weight loss medications are transforming how doctors treat obesity, diabetes, high cholesterol, and more--but while these drugs can help you lose weight, the hardest part is keeping the weight off when you stop taking them.

That's why, when you're shifting away from GLP-1 meds, you need a game plan.

Research shows that most people on weight loss drugs like Ozempic, Wegovy, and Zepbound quickly regain their weight when they stop taking medication. Whether you end treatment due to not feeling great, undesirable side effects, loss of insurance coverage, or you just want to keep your weight off without medication, without a plan in place when your body's natural hunger returns, you risk regaining it all.

Leading weight loss maintenance researchers Holly Wyatt, MD, and James Hill, PhD, share key strategies for using food, movement, and mindset to replace the medication and support long-term weight loss maintenance through an adaptable 10-week transition plan.

Chock-full of specific, actionable strategies for sustainable, lasting success, Losing the Weight Loss Meds offers everything you need to:

Develop an eating plan that maximizes satiety and minimizes "food noise" Use movement to restore your metabolism to one that is more flexible and that burns more calories Adjust your mindstate to become more resilient to better overcome obstacles and find joy in the weight loss maintenance process Effectively troubleshoot weight fluctuations before they result in significant regain Create and maintain a life you love

By embracing the journey and having a strategic plan, you can maintain your new healthier weight with ease--so you never have to worry about weight loss again.

Review Quotes

"This book is like having two super smart, empathic experts in your corner, cheering you on with science and support. Wyatt and Hill make the transition off GLP-1s feel doable, empowering, and uniquely yours. A must-read for anyone ready to maintain their weight loss with confidence and clarity."
--Bonnie Taub-Dix, RDN, CDN, author of Read It Before You Eat It: Taking You from Label to Table

"What sets this book apart is its refreshing honesty about the reader's potential appetite and weight rebound after stopping the medication, paired with realistic solutions that actually make sense . . . Wyatt and Hill provide a science-backed game plan, along with a playbook of smart, savvy, and doable strategies, to help aid in long-term success."
--Joan Salge Blake, EdD, RDN, LDN, FAND, clinical professor at Boston University and host of the Spot On! podcast

"In primary care, we celebrate when patients achieve meaningful weight loss--especially with tools like GLP-1 medications. But sustaining that success after stopping the meds? That's where the real work begins. Losing the Weight Loss Meds gives patients the road map they need. Holly Wyatt and James Hill bring science, structure, and soul to a challenge too often overlooked. This playbook is smart, practical, and empowering--just what our patients deserve."
--Irfan M. Asif, MD, family and community medicine department chair at the University of Alabama at Birmingham Heersink School of Medicine

"Threading the needle between the science and biology of body weight and the reality confronting people who live with lifetime challenges is hard. Too many people have easy answers, but real life is not so easy. Drs. Hill and Wyatt confront this reality and offer practical approaches for this challenge. They draw on years of research as well as real-life experiences in their engaging and valuable new book."
--Ted Kyle, founder of ConscienHealth

"More people are losing weight and reaching their goals, and it's time for everyone to take weight stability as seriously as they took their weight loss. Yes, it's now about understanding that continuing the journey is your weight staying where it is. That requires a different set of skills than losing weight, and Drs. Hill and Wyatt show you they not only understand this, but they walk you through the process of building those skills while giving you all the tools you'll need. They show you that weight stability is the new 'win.'"
--Keith T. Ayoob, EdD, RD, FAND, associate professor emeritus of pediatrics at the Albert Einstein College of Medicine

"This book arrives at the right time. As more patients use GLP-1 medications for weight loss, we need clear, evidence-based guidance for what comes next. Drs. Wyatt and Hill offer practical strategies rooted in physiology and clinical experience. They address the return of appetite, metabolic changes, and the behavioral adjustments needed for long-term weight regulation. This is a valuable resource for patients and clinicians."
--Victoria A. Catenacci, MD, professor of medicine at the University of Colorado, endocrinologist, and clinical researcher in obesity and metabolism

"You've already done something incredible. You lost the weight. But that's not the end of your story. It's the beginning of something even greater. This book is your playbook for that next chapter . . . Inside these pages is the truth, the strategy, and most of all, the belief that you can do this. Not just for a season. For life. You've got the power. This book shows you how to use it."
--Chris Powell, transformation coach and host of ABC's Extreme Weight Loss

"This book is an excellent resource for the millions of people who have successfully lost weight, primarily with the help of medication, and are now in the challenging position of needing to maintain that achievement for the rest of their lives. Drs. Wyatt and Hill leverage their decades of scientific and practical experience to explain in understandable terms why this is a different test from losing weight. They provide the needed variety of evidence-based plans that recognize each person's unique circumstances in their goal for lasting success."
--Michael D. Jensen, MD, professor of medicine at Mayo Clinic College of Medicine and editor-in-chief of Obesity

"Drs. Wyatt and Hill are internationally recognized experts in weight loss maintenance. In this important book, they translate the complex science of weight regulation into clear, practical guidance and provide an evidence-based framework for sustainable weight control . . . This is a valuable resource for healthcare professionals and patients committed to lasting weight management."
--Robert H. Eckel, MD, past president of The Obesity Society, American Heart Association, and American Diabetes Association

"Not everyone needs to take GLP-1 medications forever. There is no one better than Dr. Holly Wyatt and Dr. James Hill to coach you in the skills needed to succeed with long-term weight loss maintenance . . . Jim brings the science to this book, grounding it in evidence and decades of research, and Holly knows how to get in your head, to understand you and your needs--that's her superpower."
--Donna H. Ryan, MD, past president of The Obesity Society and professor emerita at the Pennington Biomedical Research Center

"In my clinical practice, I've seen how often the transition off GLP-1 medications is misunderstood--not because it's impossible, but because people aren't given the right tools and strategies. Losing the Weight Loss Meds offers a clear, science-backed playbook for navigating this phase with confidence."
--Dr. Gabrielle Lyon, board-certified and fellowship-trained physician, founder of Muscle Centric Medicine, and New York Times bestselling author of Forever Strong

"We've learned a great deal about the biology of weight regain, particularly how the body adapts to defend a lower weight. This book takes that science seriously. Drs. Wyatt and Hill apply decades of metabolic research to the real-world challenge of maintaining weight loss after GLP-1 medications are stopped."
--Paul MacLean, PhD, professor of medicine at the University of Colorado and expert in energy balance, metabolic adaptation, and obesity treatment

"Obesity is a chronic, biologically defended condition, and we now have powerful tools to help treat it. But tools alone are not enough. In this important book, Drs. Wyatt and Hill provide a thoughtful and science-based road map for those navigating the complex realities of long-term weight management. With clarity, compassion, and deep expertise, Holly and Jim help readers better understand their bodies, their behaviors, and their biology, wherever they are in the journey."
--George A. Bray, MD, Boyd professor emeritus at the Pennington Biomedical Research Center and past president of The Obesity Society

"Losing the Weight Loss Meds is the wake-up call we all need. As we step into a new era of health and healing, Drs. Wyatt and Hill offer more than science--they offer wisdom and a road map for reclaiming agency over our body, mind, and spirit . . . This book is a powerful and compassionate call to step fully into that responsibility and create sustainable health--beyond the prescription."
--Ritu Aneja, PhD, professor and associate dean for research and innovation at the University of Alabama at Birmingham School of Health Professions

"There is an urgent need for clear guidance and support for the huge numbers of people who use a GLP-1 agent to lose weight and then stop it . . . Holly Wyatt and Jim Hill are recognized as world-class leaders when it comes to weight loss maintenance. They have a tremendous gift for making weight management accessible to ordinary people. This book is a treasure-chest of ideas and game plans that will help people negotiate the obesogenic environment and avoid weight regain when GLP treatment is stopped."
--Michael Lean, MD, professor of human nutrition at the University of Glasgow

About the Author

Dr. Holly Wyatt is a leading authority in weight loss and long-term weight management, with over 25 years of experience helping people not only achieve significant weight loss but also maintain it for life. Best known as the medical doctor on the hit TV show Extreme Weight Loss, Dr. Wyatt has guided countless individuals through dramatic transformations, using her expertise in metabolism, nutrition, and behavior change. Coauthor of the bestselling book State of Slim, she specializes in creating sustainable, science-based strategies that empower people to reset their metabolism, manage their appetite, and develop healthy, lasting habits.

Dr. Wyatt's career is dedicated to helping people maintain their weight loss and improve their overall well-being by focusing on sustainable lifestyle changes rather than quick fixes. Whether through her clinical programs, media appearances, or one-on-one coaching, Dr. Wyatt's practical, personalized approach inspires people to not just reach their weight goals, but to truly transform their health and their lives in the process.

Dr. James O. Hill is a world-renowned expert in obesity, nutrition, and weight management, with over 40 years of groundbreaking research and experience in the field. As the cofounder of the National Weight Control Registry, the largest study of individuals who have successfully maintained long-term weight loss, and coauthor of State of Slim, Dr. Hill has pioneered the understanding of sustainable weight loss. His work has been instrumental in developing evidence-based strategies that empower people to achieve lasting weight management through balanced nutrition, physical activity, and behavioral changes.

Dr. Hill has published over 700 peer-reviewed articles and is widely recognized for his contributions to public health, including shaping national policies on obesity prevention and management. His expertise has been featured in major media outlets, and his research has influenced health professionals and individuals worldwide. With a passion for translating science into actionable advice, Dr. Hill continues to help people live healthier, more fulfilling lives by providing practical, long-term solutions for weight maintenance and overall well-being.