Molecular and Cellular Biology of Phagocytosis - by Robin Bishop (Hardcover)

About the Book

Phagocytosis is a vital process in immunology where specialized cells engulf and digest foreign particles, such as bacteria, debris, or apoptotic cells. This mechanism plays a crucial role in the body's defense against infections and in maintaining tissue homeostasis. Key immune cells involved include neutrophils, macrophages, and dendritic cells, each equipped with receptors that recognize specific molecules on the surface of pathogens or cellular debris. Upon recognition, the cell extends pseudopods to engulf the target, forming a phagosome within the cell. This phagosome then fuses with lysosomes, which contain digestive enzymes, resulting in the degradation of the engulfed material. Phagocytosis not only clears harmful substances but also facilitates antigen presentation, crucial for activating adaptive immune responses. Dysregulation of phagocytosis can lead to immune disorders or chronic inflammatory conditions, highlighting its essential role in maintaining health and combating diseases. This book presents the complex subject of phagocytosis in the most comprehensible and easy to understand language. It elucidates the concepts and innovative models around prospective developments with respect to immunology and cell biology. This book will help new researchers by foregrounding their knowledge in this branch.

Book Synopsis

Phagocytosis is a vital process in immunology where specialized cells engulf and digest foreign particles, such as bacteria, debris, or apoptotic cells. This mechanism plays a crucial role in the body's defense against infections and in maintaining tissue homeostasis. Key immune cells involved include neutrophils, macrophages, and dendritic cells, each equipped with receptors that recognize specific molecules on the surface of pathogens or cellular debris. Upon recognition, the cell extends pseudopods to engulf the target, forming a phagosome within the cell. This phagosome then fuses with lysosomes, which contain digestive enzymes, resulting in the degradation of the engulfed material. Phagocytosis not only clears harmful substances but also facilitates antigen presentation, crucial for activating adaptive immune responses. Dysregulation of phagocytosis can lead to immune disorders or chronic inflammatory conditions, highlighting its essential role in maintaining health and combating diseases. This book presents the complex subject of phagocytosis in the most comprehensible and easy to understand language. It elucidates the concepts and innovative models around prospective developments with respect to immunology and cell biology. This book will help new researchers by foregrounding their knowledge in this branch.