Pure Encapsulations Ultra B-Complex with PQQ - Vitamin B Supplement to Support Nerves, Cells, Methylation, and Mitochondrial Health* - 60 Capsules

Ultra B-Complex w/PQQ combines B-complex vitamins with PQQ for unique support of mitochondrial bioenergetics and function. The B-complex vitamins are essential to basal mitochondrial function as metabolic coenzymes and methyl donors. Thiamin and niacin support healthy neuron cell longevity, neuronal membrane function and impulse conduction. 5-MTHF, methylcobalamin and vitamin B6 support neuronal health as methylation cofactors in myelin and neurotransmitter biosynthesis. Adenosylcobalamin is the form of vitamin B12 active in mitochondria, boosting mitochondrial energy (ATP) production, at least in part by supporting MCM enzyme activity, which declines with age. Animal studies suggest it specifically enhances mitochondrial bioenergetics, promotes type IIA fast twitch muscle fiber size during aging, stabilizes neuro-muscular junctions, and supports healthy myelination of the peripheral nervous system innervating muscle. PQQ provides novel B vitamin-like activity with advanced antioxidant properties that protect and enhance mitochondrial, neuronal, and cellular function, at least in part by activation of Nrf2 and up-regulation of antioxidant genes, and cytokine balance. Studies indicate significant support for cognitive function, including increased cerebral blood flow and oxygen metabolism. Preliminary research suggests it promotes mitochondrial biogenesis by targeting SIRT1 and PGC-1α. Alpha lipoic acid provides additional support for mitochondrial energy utilization and combined with luteolin, offers enhanced nervous system antioxidant activity. Research suggests luteolin also helps maintain healthy macrophage activity and gene expression of the nervous system. *