T-Follicular Helper Cells in Immune Responses - by Josiah Robinson (Hardcover)

About the Book

T-Follicular Helper (Tfh) cells are a subset of T cells crucial for orchestrating the adaptive immune response within germinal centers of lymphoid organs. They play a pivotal role in the generation and maintenance of high-affinity antibody responses by interacting with B cells. Tfh cells express CXCR5, which guides their migration to B cell follicles in lymphoid tissues, where they engage in cell-to-cell interactions with B cells through costimulatory molecules like CD40L and cytokines such as IL-21. This interaction promotes B cell proliferation, antibody class switching, and affinity maturation, crucial for effective humoral immunity against pathogens. Dysregulation of Tfh cells can lead to autoimmune diseases or impaired immune responses to infections. Understanding the biology of Tfh cells is essential for developing vaccines and therapies that enhance immune responses against pathogens while preventing immune-mediated disorders. This book will also provide interesting topics for research which interested readers can take up. The various advancements in immunology are glanced at and their applications as well as ramifications are looked at in detail. This book, with its detailed analyses and data, will prove immensely beneficial to professionals and students involved in this area at various levels.

Book Synopsis

T-Follicular Helper (Tfh) cells are a subset of T cells crucial for orchestrating the adaptive immune response within germinal centers of lymphoid organs. They play a pivotal role in the generation and maintenance of high-affinity antibody responses by interacting with B cells. Tfh cells express CXCR5, which guides their migration to B cell follicles in lymphoid tissues, where they engage in cell-to-cell interactions with B cells through costimulatory molecules like CD40L and cytokines such as IL-21. This interaction promotes B cell proliferation, antibody class switching, and affinity maturation, crucial for effective humoral immunity against pathogens. Dysregulation of Tfh cells can lead to autoimmune diseases or impaired immune responses to infections. Understanding the biology of Tfh cells is essential for developing vaccines and therapies that enhance immune responses against pathogens while preventing immune-mediated disorders. This book will also provide interesting topics for research which interested readers can take up. The various advancements in immunology are glanced at and their applications as well as ramifications are looked at in detail. This book, with its detailed analyses and data, will prove immensely beneficial to professionals and students involved in this area at various levels.