Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging - (NATO Asi Series) (Hardcover)

Book Synopsis

Background.- Aging, Comorbidity, and Breast Cancer Survival: An Epidemiologic View.- Squamous Cell Cancer of the Cervix, Immune Senescence and HPV: Is Cervical Cancer an Age-Related Neoplasm?.- Genetics and Epigenetics.- Genetic and Molecular Basis for Cellular Senescence.- A Single Gene Change Can Extend Yeast Life Span: The Role of ras in Cellular Senescence.- A Comparison of the Properties of Human P53 Mutant Alleles.- Gene Structure and Expression in Colorectal Cancer.- Influence of Physiological Changes in the Immune Constitutions in Aging and Cancer.- Tumors and Aging: The Influence of Age-Associated Immune Changes upon Tumor Growth and Spread.- T Cell Differentiation and Functional Maturation in Aging Mice.- Molecular Biology of Age-Related Changes in Some Types of Cancer.- I. Breast Cancer.- Cytogenetics and Clinical Correlations in Breast Cancer.- Breast Cancer: Influence of Endocrine Hormones, Growth Factors and Genetic Alterations.- Regulation of Estrogen Receptor Expression in Breast Cancer.- Aging and Development of Ovarian Epithelial Carcinoma: The Relevance of Changes in Ovarian Stromal Androgen Production.- II. Prostate Cancer.- Prostatic Cancer: An Age-Old Problem.- Stromal-Epithelial Paracrine Interactions in the Neoplastic Rat and Human Prostate.- Heparin-Binding Fibroblast Growth Factors and Prostate Cancer.- Molecular Epidemiology and Treatment Modality in Patients of Different Ages with Leukemias.- Age Related Changes in Adults with Acute Leukemia.- Significance of Chromosomal Chances in Patients of Different Age Groups with Acute Leukemia.- Glucocorticoid Receptors in Leukemias, Lymphomas and Myelomas of Young And Old.- Drug Resistance.- General Aspects of Cancer Chemotherapy in the Aged.- Drug Resistance and Cancer.- Summation and Synthesis.- From the Cancer Cell Biology Point of View.- From the Immunology Point of View.- From the Aging Point of View.- Participants and Contributors.