Hand wipes are offered both unscented (fragrance-free) and scented. Common scented listings describe "fresh" or "tropical" varieties, while many items are specifically labeled fragrance-free.

Many hand-wipe listings make gentle-skin claims such as hypoallergenic, dye-free, and paraben-free; some are labeled pediatrician- or dermatologist-tested and marketed for sensitive skin.

Some wet wipes are labeled flushable for use with well-maintained plumbing, but many hand and cleansing wipes explicitly state "do not flush."

Reviewers frequently praise fragrance-free or gentle formulas for sensitive skin, effective cleaning without drying, and portable packaging that keeps wipes moist for on-the-go use.

Most hand wipes list dimensions around 7.2–7.9 inches long by about 5–5.9 inches wide. Some extra-large cleansing cloth listings show sizes up to approximately 12 inches by 8 inches.