Standard caplets and gelcaps are described as providing relief for up to six hours. The extended‑release (long‑lasting) caplets are described as providing relief for up to eight hours.
Warnings include consulting a doctor if you are pregnant or nursing or have conditions such as stomach problems, diabetes, liver disease, glaucoma, prostate issues, or breathing problems. Do not use with other medicines that contain acetaminophen, keep out of reach of children, and ask a doctor or pharmacist before use if you are taking warfarin.