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Differin Epiduo Acne Gel Adapalene & Benzoyl Peroxide Acne Treatment - 2 of 4Differin Epiduo Acne Gel Adapalene & Benzoyl Peroxide Acne Treatment - 3 of 4Differin Epiduo Acne Gel Adapalene & Benzoyl Peroxide Acne Treatment - 4 of 4
Differin Epiduo Acne Gel Adapalene & Benzoyl Peroxide Acne Treatment - 1 of 4

Differin Epiduo Acne Gel Adapalene & Benzoyl Peroxide Acne Treatment - 15g/0.5oz

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New at  target 
Size15g/0.5oz

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At a glance

About this item

Highlights

  • RX STRENGTH, DUAL ACTIVE FORMULA: The most effective acne treatment approved by the FDA for use over the counter. The only OTC acne care product combining benzoyl peroxide 2.5% and retinoid adapalene 0.1% gel. FSA/HSA eligible
  • TREATS AND PREVENTS ACNE: Benzoyl peroxide kills bacteria from day 1 while adapalene unclogs pores and prevents future breakouts—together they help clear acne better than single-active alternatives
  • FOR ALL SKIN TYPES: Works for all skin tones and types, including sensitive and oily skin. Helps remove blemishes. Treats clogged pores, blackheads, whiteheads, nodules, papules, and pustules. Face acne treatment, chest acne treatment, and back acne treatment
  • REAL RESULTS FOR RECURRENT ACNE: In one clinical study, Differin Epiduo acne skin care treatment significantly reduced total acne by 65% after 12 weeks. Differin Epiduo treats acne, improving acne-prone skin's overall tone, texture, and radiance
  • HOW TO USE: 1. Wash skin gently and pat dry. 2. Use one pump of Epiduo (a pea-sized amount) a day for your full face. 3. Moisturize after applying the gel. 4. Use SPF30+ during the day, as Differin Epiduo can make your skin more sensitive to the sun
  • USAGE TIPS: You can start slow by using Epiduo every other day or every third day, gradually working up to daily use. Use plenty of moisturizer and wear SPF30+ during the day. Can use morning or night

Description

Differin Epiduo Acne Gel (30 day supply) is the most effective acne treatment approved by the FDA for use over the counter. This treatment is a prescription-strength, dual-active formula, the only OTC product combining benzoyl peroxide 2.5% and retinoid adapalene 0.1%. Uniquely engineered to amplify results. Differin Epiduo is ideal for adults with clogged pores, blackheads, whiteheads, pimples and stubborn acne. Helps treat and prevent acne and even skin tone. In one clinical study, Differin Epiduo acne skin care treatment significantly reduced total acne by 65% after 12 weeks. In the first few weeks of use, as your skin adjusts to the retinoid, you may experience dryness, redness or peeling. Some may see improvement in their acne, others may stay the same or worsen before it starts to improve. Within 4 to 12 weeks of use, users should experience fewer breakouts. Dermatologists recommend using Differin Epiduo with plenty of moisturizer as well as SPF30+ during the day. If pregnant or breastfeeding, speak with your doctor before using. Avoid waxing while using. Okay to use with other products that include hydrating, barrier repairing ingredients. Do not use with any other acne fighting ingredients like Salicylic Acid, Benzoyl peroxide, or retinols. Avoid exfoliating ingredients.
Scent: Unscented
Trial/Mini/Travel Size: Yes
Health Facts: Alcohol-Free, Oil-Free, Noncomedogenic, Water-Based
Product Form: Gel
Package Quantity: 1
Beauty Purpose: Anti-Acne
Recommended Skin Type: Acne-Prone
Features: Dermatologist Tested, Nongreasy, Dermatologist Recommended
TCIN: 95193290
UPC: 302994908103
Item Number (DPCI): 037-12-0777
Origin: Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Active ingredients

adapalene (retinoid)*' '0.1% benzoyl peroxide' '2.5% ' '

Purpose

Acne treatment Acne treatment

Directions

Directions ■ Adults and children 12 years of age and older: ■ use once daily ■ clean the skin gently and pat dry before applying the product ■ cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face. ■ applying more than directed will not provide faster or better results, but may worsen skin irritation ■ if going outside, apply sunscreen after using this product. If irritation or sensitivity develops, stop use of both products and ask a doctor. ■ Children under 12 years of age: do not use

Other information

All trademarks are the property of their respective owners.

Inactive ingredients

inactive ingredients: acrylamide/sodium acryloyldimethyltaurate copolymer, docusate sodium, edetate disodium, glycerin, isohexadecane, poloxamer 124, polysorbate 80, propylene glycol, purified water, and sorbitan oleate

Shipping details

Estimated ship dimensions: 1.6 inches length x 2.65 inches width x 6.27 inches height
Estimated ship weight: 0.11 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Q: Can I use this on my back?

submitted by Ms1124 - 1 month ago
See all questions (1)

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Guests are saying

The Differin Epiduo Acne Gel is a highly effective treatment for acne, combining adapalene and benzoyl peroxide to deliver noticeable results. Guests appreciate its smooth texture, quick absorption, and gentle formulation that minimizes irritation. With consistent use, many have reported clearer skin, reduced breakouts, and improved overall complexion. The convenient packaging and lightweight feel make it an ideal addition to any skincare routine, especially for those with sensitive skin.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.7 out of 5 stars with 97 reviews
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    100% would recommend
    2 recommendations
    5 out of 5 stars
    17 August, 2026
    originally posted on differin.com
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    Works in acne

    [This review was collected as part of a promotion.] The differing epiduo acne gel is definitely a product to try! It minimized the pimples I had on my face really quick! The only problem is it can dry for face quick too.
    IsabelA
    Did you find this review helpful?
    3 out of 5 stars
    17 August, 2026
    originally posted on differin.com
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    Delicate

    [This review was collected as part of a promotion.] The consistency is good. I don’t really think it’s made for all skin types in my opinion I started to used it and not gonna lie I broke out more than I used to.it has no smell
    LilithK
    Did you find this review helpful?
    5 out of 5 stars
    15 August, 2026
    originally posted on differin.com
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    Visible Improvement in My Skin

    [This review was collected as part of a promotion.] I’ve been using Differin Epiduo Acne Gel and I’m really happy with the results so far. My skin looks clearer, my breakouts appear less noticeable, and the overall texture of my skin has improved. I like that it targets active acne while also helping my skin look smoother over time. I’m going to keep using it consistently because I can already see a difference in my skin.
    YanelisT
    Did you find this review helpful?
    5 out of 5 stars
    15 August, 2026
    originally posted on differin.com
    Image

    Easy to use, fragrance-friendly, and a great addition to my acne skincare routine.

    [This review was collected as part of a promotion.] I like this gel because it’s easy to add to my routine. It has no strong scent, the packaging is convenient, and a small amount goes a long way. It can be a little drying at first, so I use moisturizer after applying it
    SurelysG
    Did you find this review helpful?
    5 out of 5 stars
    14 August, 2026
    originally posted on differin.com
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    Great acne gel with fast results!

    [This review was collected as part of a promotion.] I’ve been testing the Differin Epiduo Acne Gel for the past few weeks and I’ve really noticed a great difference in my skin texture. It helped clear up stubborn breakouts without overly drying out my skin. It feels gentle yet effective. This is definitely becoming a staple in my daily skincare routine!
    DayanelisB
    Did you find this review helpful?
    1 out of 5 stars
    14 August, 2026
    originally posted on differin.com
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    RIP to my skin barrier

    I followed all instructions. I used a pea-sized amount, started out using every other day, and moisturized and ended up with a burning, itching rash all over my face. I ended up needing both oral and topical steroids. Be careful if you have sensitive and stop if you have any burning or redness!
    Bailey K
    Did you find this review helpful?
    5 out of 5 stars
    14 August, 2026Verified purchase

    (no review title)

    Very hydrating and not irritating on skin
    Did you find this review helpful?
    2 out of 5 stars
    13 August, 2026
    originally posted on differin.com
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    Not for sensitive skin

    [This review was collected as part of a promotion.] Unfortunately this product did not work. It caused even more redness and break outs along with burning and itchiness to the point it had to stop being used.
    LiaC
    Did you find this review helpful?
    5 out of 5 stars
    13 August, 2026
    originally posted on differin.com
    Image

    It worked for me, I have sensitive skin and acne!!

    [This review was collected as part of a promotion.] It really doesn’t usually occupy any product on my skin! Because it takes out pimples but I would definitely buy this one again, it dries the pimples, removes the spots from your skin!!!❤️❤️
    KimberlyC
    Did you find this review helpful?
    5 out of 5 stars
    13 August, 2026
    originally posted on differin.com
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    The best!

    [This review was collected as part of a promotion.] This has changed my life. When I say nothing would work, NOTHING would work! My acne was so bad and this has helped my skin clear up perfectly! I absolutely recommend! So, so good!
    KatelynF
    Did you find this review helpful?
    5 out of 5 stars
    13 August, 2026
    originally posted on differin.com
    Image

    Excellent for controlling acne, although it requires patience and hydration.

    [This review was collected as part of a promotion.] The application of the gel is quite simple and its texture is light. During the first weeks I felt a slight burning sensation and some peeling but when accompanying it with a good moisturizer the skin adapted very well. It has significantly reduced the outbreaks and improved the texture of my face. Its cost is totally worth it.
    YailinD
    Did you find this review helpful?
    5 out of 5 stars
    13 August, 2026
    originally posted on differin.com
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    The solution it gave to my skin

    [This review was collected as part of a promotion.] This is honestly a great product, it comes with the soap and moisturizer. It has helped me a lot with my acne and aswell with acne scars. You need to be consistent tho. Intruccions are clear and effective, it cleans your skin deeply
    TaniaM
    Did you find this review helpful?
    5 out of 5 stars
    13 August, 2026
    originally posted on differin.com
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    So far so good…

    [This review was collected as part of a promotion.] So far so good, I’ve been using it with the cetaphil cleanser and moisturizer. No peeling so far, and it’s progressing nicely but haven’t seen results yet.
    ElizabethO
    Did you find this review helpful?
    5 out of 5 stars
    12 August, 2026
    originally posted on differin.com
    Image

    A great acne treatment that’s easy to add to your routine and helps improve the look of your skin.

    [This review was collected as part of a promotion.] I’ve been using this product for four weeks, and honestly, it has been one of the best. I apply a small amount to my skin once a day, and I’ve noticed a difference in my acne and overall skin texture. I didn’t experience any dryness or peeling, which I really liked. I’m very happy with the results so far and will definitely keep using it!
    GrismarlyP
    Did you find this review helpful?
    5 out of 5 stars
    11 August, 2026
    originally posted on differin.com
    Image

    Effective acne treatment with an easy to apply formula .

    [This review was collected as part of a promotion.] This acne gel is easy to apply and has a lightweight consistency. It absorbs well and dries quickly without feeling too heavy on my skin. With consistent use, I noticed fewer breakouts and my skin looked cleared and smoother.
    LiliaT
    Did you find this review helpful?
    5 out of 5 stars
    11 August, 2026
    originally posted on differin.com
    Image

    Push through the purge!!

    [This review was collected as part of a promotion.] Omg!! I’ve used practically every over-the-counter acne medication (along with many prescription ones) and nothing has ever made much of a difference. TIL now!! First, the purge is ROUGH. It will look bad but it gets so good!!!
    TiarraK
    Did you find this review helpful?
    5 out of 5 stars
    11 August, 2026
    originally posted on differin.com
    Image

    A good acne treatment that works, but you definitely need to keep your skin well moisturized.

    [This review was collected as part of a promotion.] Helps keep my skin clean and improves breakouts over time.It can feel drying and cause some sensitivity and light peeling at first,so hydration is important.Overall, I’ve noticed clearer,smoother-looking skin with consistent use.
    LianetG
    Did you find this review helpful?
    5 out of 5 stars
    10 August, 2026
    originally posted on differin.com
    Image

    Goood

    [This review was collected as part of a promotion.] I have oily acne prone skin i tend to break out alot and have some texture but this cream has really helped slowly get rid of it. It has been added to my daily night routine i love it.
    CitlallyL
    Did you find this review helpful?
    5 out of 5 stars
    9 August, 2026
    originally posted on differin.com
    Image

    My ally against acne

    [This review was collected as part of a promotion.] I like that it is not greasy, it dries my pimples super fast and does not hurt my skin... it has no strong aromas and absorbs super well in my skin. Although I apply it daily because it can dry out a little
    GlorisG
    Did you find this review helpful?
    5 out of 5 stars
    7 August, 2026
    originally posted on differin.com
    Image

    Effective acne treatment with great packaging—just be sure to moisturize consistently.

    [This review was collected as part of a promotion.] I’ve been using the Differin Epiduo Acne Gel consistently, and I’ve noticed a visible improvement in my breakouts. The pump packaging is very convenient and dispenses the right amount of product without wasting it. It works gradually, so patience is important, but the results are worth it. I experienced a little dryness during the first weeks, which is normal, so I made sure to use a good moisturizer. I didn’t experience significant redness, and overall I’m very happy with the results.
    DileimyS
    Did you find this review helpful?

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