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Dynamics and Kinetics in Structural Biology - by Keith Moffat & Eaton E Lattman (Hardcover)
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Highlights
- Dynamics and Kinetics in Structural Biology Understand the latest experimental tools in structural biology with this pioneering work Structural biology seeks to understand the chemical mechanisms and functions of biological molecules, such as proteins, based on their atomic structures.
- About the Author: Keith Moffat, PhD is the Louis Block Distinguished Service Professor of Biochemistry and Molecular Biology and a founding member of the Institute for Biophysical Dynamics, University of Chicago, USA.
- 288 Pages
- Science, Physics
Description
About the Book
"Why study structure in biology? The imaging of structure has long been of interest, where structures range in length scale from an entire ecosystem to the gross anatomy of the human body, to cellular, molecular, and atomic structure. Here, we concentrate on structure at the molecular and atomic level and on the essential, dynamic variations in structure with time. Determining biological structure at this level is undeniably powerful, as evidenced by the library of more than 160,000 experimental and increasingly, computational structures in the Protein Data Bank (PDB). An arguably more interesting reason is broader: structure at the molecular and atomic level provides a powerful avenue into understanding both function and mechanism."--Book Synopsis
Dynamics and Kinetics in Structural BiologyUnderstand the latest experimental tools in structural biology with this pioneering work
Structural biology seeks to understand the chemical mechanisms and functions of biological molecules, such as proteins, based on their atomic structures. Until recently, these structures have been studied only statically, using procedures which deliberately freeze atomic motion. However, freezing eliminates the rapid structural motions so essential to biological activity and function; the molecules are inactive. But with the recent development of X-ray free electron laser (XFEL) sources, efforts to conduct dynamic experiments have expanded using the principles of dynamics and kinetics to capture active biological molecules as they function.
Dynamics and Kinetics in Structural Biology promotes the development of these experiments and their successful application. It grounds readers in the foundational principles of dynamics and kinetics; proceeds through extended discussions of experimental procedures and data analysis techniques; and explores experimental frontiers in structural dynamics. The book will aid researchers to gather and interpret cutting-edge data on the dynamic structure of biological molecules, under conditions where they retain their biological functions.
Dynamics and Kinetics in Structural Biology offers readers:
- Authorship by founding figures in the field
- In-depth presentation of time-resolved X-ray crystallography, solution scattering, and more
- A pioneering contribution to a rapidly developing field of study
Dynamics and Kinetics in Structural Biology is essential reading for graduate students, scientists, researchers and industry professionals engaged in structural studies of biological systems. Industry professionals considering dynamic studies in the development of new product lines will also benefit.
From the Back Cover
Understand the latest experimental tools in structural biology with this pioneering work
Structural biology seeks to understand the chemical mechanisms and functions of biological molecules, such as proteins, based on their atomic structures. Until recently, these structures have been studied only statically, using procedures which deliberately freeze atomic motion. However, freezing eliminates the rapid structural motions so essential to biological activity and function; the molecules are inactive. But with the recent development of X-ray free electron laser (XFEL) sources, efforts to conduct dynamic experiments have expanded using the principles of dynamics and kinetics to capture active biological molecules as they function.
Dynamics and Kinetics in Structural Biology promotes the development of these experiments and their successful application. It grounds readers in the foundational principles of dynamics and kinetics; proceeds through extended discussions of experimental procedures and data analysis techniques; and explores experimental frontiers in structural dynamics. The book will aid researchers to gather and interpret cutting-edge data on the dynamic structure of biological molecules, under conditions where they retain their biological functions.
Dynamics and Kinetics in Structural Biology offers readers:
- Authorship by founding figures in the field
- In-depth presentation of time-resolved X-ray crystallography, solution scattering, and more
- A pioneering contribution to a rapidly developing field of study
Dynamics and Kinetics in Structural Biology is essential reading for graduate students, scientists, researchers and industry professionals engaged in structural studies of biological systems. Industry professionals considering dynamic studies in the development of new product lines will also benefit.
About the Author
Keith Moffat, PhD is the Louis Block Distinguished Service Professor of Biochemistry and Molecular Biology and a founding member of the Institute for Biophysical Dynamics, University of Chicago, USA. He pioneered the technique of time-resolved crystallography and has published very widely in the fields of biophysics and biochemistry.
Eaton E. Lattman, PhD has served as Professor at the Johns Hopkins University and the University at Buffalo, among other roles. He was director of BioXFEL, an NSF-sponsored center for the application of X-ray lasers to biology. He has years of experience in the fields of X-ray crystallography, structural biology, and related areas.