Sponsored
Nighttime Cold & Flu Multi-symptom Relief Liquid - 12 fl oz - up&up™
Only at target
$4.89 ($0.41/fluid ounce) reg $6.99
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save $2.10 (30% off)In Stock
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About this item
Highlights
- Packaging may vary. Same trusted quality
- ACTIVE INGREDIENTS: Compare to NyQuil Cold and Flu active ingredients: acetaminophen (pain reliever and fever reducer), dextromethorphan HBr (cough suppressant), and doxylamine succinate (antihistamine)
- MAXIMUM STRENGTH: Each 30 mL dose provides maximum strength, multi-symptom relief to help you sleep
- POWERFUL NIGHTTIME RELIEF: When used at night, this medicine relieves minor aches and pains, fever, sore throat, sneezing, runny nose and cough for up to 6 hours so you can rest
- LIQUID MEDICINE: In original flavor, this syrup provides the relief you need in a soothing liquid; dosage cup included
- AGES 12 AND OLDER: This cold and flu medicine is safe for adults and children ages 12 and over; gluten free
Description
Compare to NyQuil Cold and Flu active ingredients. Calm your cold and flu symptoms so you can rest with Nighttime Cold and Flu Relief by up&up. When taken every six hours, each dose provides powerful relief for your minor aches and pains, fever, sore throat, sneezing, runny nose and cough. This liquid syrup combines acetaminophen (pain reliever/fever reducer), dextromethorphan HBr (cough suppressant) and doxylamine succinate (antihistamine) with ten percent alcohol to give you maximum strength, multi-symptom relief that lasts six hours. Dosage cup included. For ages 12 and over. Gluten free.
We believe making smart choices for the people, places, and pets in your life should be easy and affordable. And, having quality you can trust should be a given. That’s why you can count on our promise – caring for your everyday in every way.
Satisfaction guaranteed – Love it or your money back.
We believe making smart choices for the people, places, and pets in your life should be easy and affordable. And, having quality you can trust should be a given. That’s why you can count on our promise – caring for your everyday in every way.
Satisfaction guaranteed – Love it or your money back.
Suggested Age: 12 Years and Up
Health Facts: Contains Dextromethorphan
Active Ingredient Strength Value: 650 Milligrams
Product Warning: Consult a doctor if you have liver disease, consult a doctor if you have a breathing problem, keep out of reach of children, consult a doctor if on a sodium-restricted diet, consult a doctor if taking prescription drugs, ask a doctor if you have prostate issues, consult a doctor if you are pregnant or nursing
Product Form: Liquid
Primary Active Ingredient: Acetaminophen
Package Quantity: 1
Net weight: 12 fl oz (US)
Features: Nighttime Use
TCIN: 16695461
UPC: 311673287019
Item Number (DPCI): 094-14-0148
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.
Active ingredients
acetaminophen' '650.0mg dextromethorphan hbr' '30.0mg doxylamine succinate' '12.5mg
Purpose
Pain reliever/fever reducer Cough suppressant AntihistamineUses
Uses temporarily relieves common cold/flu symptoms: cough due to minor throat and bronchial irritation, sore throat, headache, minor aches and pains, fever, runny nose and sneezingDirections
Directions take only as directed, only use the dose cup provided, do not exceed 4 doses per 24 hrs, adults & children 12 yrs & over 30 mL every 6 hrs children 4 to under 12 yrs ask a doctor children under 4 yrs do not useOther information
Other information each 30 mL contains: sodium 52 mg, store at no greater than 25°C and do not refrigerateInactive ingredients
alcohol, anhydrous citric acid, fd&c blue no. 1. fd&c red no. 40, flavor, glycerin, polyethylene glycol, propylene glycol, purified water, sodium benzoate, sodium citrate, sodium saccharin, sorbitol solution, sucralose, xanthan gum' '
Shipping details
Estimated ship dimensions: 2.06 inches length x 2.65 inches width x 7.08 inches height
Estimated ship weight: 0.94 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 365 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup.
See the return policy for complete information.
Q: What is the primary active ingredient in this product?
submitted by AI Shopping Assistant - 9 days ago
A: The primary active ingredient is acetaminophen, which acts as a pain reliever and fever reducer.
submitted byAI Shopping Assistant - 9 days agoAi generated
Q: Does this medicine contain gluten?
submitted by AI Shopping Assistant - 9 days ago
A: No, this cold and flu medicine is gluten-free.
submitted byAI Shopping Assistant - 9 days agoAi generated
Q: How long does the relief from this medicine last?
submitted by AI Shopping Assistant - 9 days ago
A: The relief lasts for up to 6 hours per dose.
submitted byAI Shopping Assistant - 9 days agoAi generated
Q: Is this product suitable for children under 12?
submitted by AI Shopping Assistant - 9 days ago
A: No, this product is recommended for ages 12 and older.
submitted byAI Shopping Assistant - 9 days agoAi generated
Q: What symptoms does this liquid medicine relieve?
submitted by AI Shopping Assistant - 9 days ago
A: It relieves minor aches, pains, fever, sore throat, sneezing, runny nose, and cough.
submitted byAI Shopping Assistant - 9 days agoAi generated
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4.8 out of 5 stars with 399 reviews
quality: 4.4 out of 5
value: 4.47 out of 5
81% would recommend
16 recommendations
2 out of 5 stars
Thumbs down graphic, would not recommend
5 September, 2025
Not comparable
This is not comparable to Vicks. I have to take the recommended dose and a half to sleep through the night with a really bad cough. It tastes like black licorice, I was expecting similar tastes as Vicks. Overall, I would not buy again. I would recommend this to those who like black licorice and is looking for a weaker Vicks.
5 out of 5 stars
Thumbs up graphic, would recommend
12 July, 2025Verified purchase
Good
When I am very sick this is the medicine I take
5 out of 5 stars
Thumbs up graphic, would recommend
13 March, 2025
Exit Light, Enter Night
When I opened the cap, Enter Sandman by Metallica started playing. 30 ml and I was off to Never Never Land.
5 out of 5 stars
Thumbs up graphic, would recommend
13 July, 2024Verified purchase
Super strength
I am not a fan of strong drugs, but when I had a severe cold this was the only thing that gave me relief. I can’t imagine being that sick without it!
5 out of 5 stars
Thumbs up graphic, would recommend
20 May, 2024Verified purchase
Works great yo alleviate cold ans flu stmptoms
The Nightime Cold and Flu medicine works great for me. It helps my cold symptoms and helps put me to sleep when I struggle with coughing and sniffing all night.
5 out of 5 stars
Thumbs up graphic, would recommend
9 April, 2024Verified purchase
Slept like a baby
My husband was not sleeping well at all while he was sick. He took this and slept like a baby. Although it worked great for him it kept me up because of his snoring. Would recommend if you’re sick and are not sleeping well.
5 out of 5 stars
23 February, 2024Verified purchase
Nightime Cold Medicine
Target brand is less expensive and works the same as brand name nighttime cold medicine.
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Thumbs up graphic, would recommend
3 February, 2024Verified purchase
Generic Nyquil
Very similar to NyQuil. I use them interchangeably.
4 out of 5 stars
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11 January, 2024Verified purchase
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Although the product is fine_ we could have drove across country and brought it home quicker!
5 out of 5 stars
Thumbs up graphic, would recommend
28 December, 2023Verified purchase
Equivalent
Just as good as the real stuff
5 out of 5 stars
Thumbs up graphic, would recommend
1 December, 2023Verified purchase
Just like the name brand
Works just like NyQuil but cheaper!!
1 out of 5 stars
Thumbs down graphic, would not recommend
4 March, 2023Verified purchase
Disgustinf taste
Does the job but the taste is awful! Like a cross between black licorice and some liquor.
5 out of 5 stars
Thumbs up graphic, would recommend
29 December, 2022Verified purchase
Decent product
It's a good product. The generic version of nyquil.
5 out of 5 stars
15 November, 2022Verified purchase
Awesome! Better than name brand.
I will buy this every time! It is priced great and works just as good if not better than name brand.
1 out of 5 stars
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18 September, 2022Verified purchase
Not Worth The Effort
Good product, at a very comparible price, however, it is near impossible to get the bottle opened. The last four (4) bottles I bought, I ended up having to saw the tops off to access the contents.
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6 September, 2022Verified purchase
Good value
Works as expected and like a charm. I can’t tell the difference between Up&Up and the name brand versions. If you’re sick and need a good night of rest, save yourself some money and get this!
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12 October, 2021Verified purchase
It works just like the brand name version
Just as good as Nyquil but costs less...works for me!
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15 March, 2021Verified purchase
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I take one teaspoon every night to help me sleep
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6 December, 2020Verified purchase
(no review title)
Up & Up night time cold and flu is no different than the name brand NyQuil - AND the cost is much less! Why pay more? I am a skeptic when it comes to generic brands, but this works! It’s my go-to for cold and flu med.