Oral Bioavailability and Drug Delivery - (Wiley Drug Discovery and Development) by Ming Hu & Xiaoling Li (Hardcover)

About the Book

"This book comprehensively covers the topics and issues of oral bioavailability and applications in drug development. The book helps readers master the basic terminology of the field, understand the basic barriers to oral bioavailability, be acquainted with the methods used to determine relevant parameters, and comprehend the challenge associated with oral drug delivery. The first part covers the basic concept of oral bioavailability and factors that influence oral bioavailability. The second part covers the advanced concept and recent progress in predicting and improving oral bioavailability. The third part presents techniques or technologies that are used to characterize oral absorption, predict and improve oral bioavailability. In addition, some chapters use a mix of questions-answers, discussion questions, and examples of methods in action"--

Book Synopsis

ORAL BIOAVAILABILITY AND DRUG DELIVERY

Improve the performance and viability of newly-developed and approved drugs with this crucial guide

Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user's circulatory system depending on the method of administration. For example, intravenous administration produces a bioavailability of 100%, since the drugs are injected directly into the circulatory system; in the case of oral administration, however, bioavailability can vary widely based on factors which, if not properly understood, can result in a failure in drug development, adverse effects, and other complications. The mechanics of oral bioavailability are therefore critical aspects of drug development.

Oral Bioavailability and Drug Delivery provides a comprehensive coverage of this subject as well as its drug development applications. Beginning with basic terminology and fundamental concepts, it provides a thorough understanding of the challenges and barriers to oral bioavailability as well as the possibilities for improving this parameter. The resulting book is an indispensable tool for drug development research.

Oral Bioavailability and Drug Delivery readers will also find:

• Discussion questions in many chapters to facilitate comprehension
• Detailed discussion of topics including dissolution, absorption, metabolism, and more
• Real-world examples of methods in actions throughout

Oral Bioavailability and Drug Delivery is ideal for pharmaceutical and biotechnology scientists working in drug discovery and development; researchers in chemistry, biology, pharmacology, immunology, neuroscience, and other related fields; and graduate courses in drug development and delivery.

From the Back Cover

Improve the performance and viability of newly-developed and approved drugs with this crucial guide

Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user's circulatory system depending on the method of administration. For example, intravenous administration produces a bioavailability of 100%, since the drugs are injected directly into the circulatory system; in the case of oral administration, however, bioavailability can vary widely based on factors which, if not properly understood, can result in a failure in drug development, adverse effects, and other complications. The mechanics of oral bioavailability are therefore critical aspects of drug development.

Oral Bioavailability and Drug Delivery provides a comprehensive coverage of this subject as well as its drug development applications. Beginning with basic terminology and fundamental concepts, it provides a thorough understanding of the challenges and barriers to oral bioavailability as well as the possibilities for improving this parameter. The resulting book is an indispensable tool for drug development research.

Oral Bioavailability and Drug Delivery readers will also find:

• Discussion questions in many chapters to facilitate comprehension
• Detailed discussion of topics including dissolution, absorption, metabolism, and more
• Real-world examples of methods in actions throughout

Oral Bioavailability and Drug Delivery is ideal for pharmaceutical and biotechnology scientists working in drug discovery and development; researchers in chemistry, biology, pharmacology, immunology, neuroscience, and other related fields; and graduate courses in drug development and delivery.

About the Author

Ming Hu, PhD, is Professor of Pharmaceutics at the College of Pharmacy, University of Houston, Texas, USA.

Xiaoling Li, PhD, is Professor of Pharmaceutics at the TJL School of Pharmacy, University of the Pacific, California, USA.