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Common active ingredients include topical anesthetics and antiviral or soothing agents. Frequently listed are benzocaine, menthol, and docosanol; some formulations also include soothing components such as lysine, calendula, olive oil, and propolis.

Directions vary by product. Examples include an antiviral cream that specifies applying up to five times a day (maximum 10 days) and a mouth rinse recommended up to four times daily after meals. Other products and user reviews note that some users reapply more frequently; always follow the specific product label for exact timing and limits.

Labels and descriptions commonly report mint or menthol flavors; some products are unflavored, while thicker balm-like formulas may have mild tastes or scents.

Labels commonly list suggested ages such as 2 years and up, 12 years and up, and 18 years and up. Some products recommend adult supervision for younger children or include additional age-based precautions.

Typical label warnings include keeping products out of reach of children and specific age restrictions such as "Not for children under the age of two." Many products list suggested ages (e.g., 2+, 12+, 18+) and recommend adult supervision for younger children.