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Enfamil Optimum Enspire Powder Infant Formula - 20.5oz - 2 of 4Enfamil Optimum Enspire Powder Infant Formula - 20.5oz - 3 of 4Enfamil Optimum Enspire Powder Infant Formula - 20.5oz - 4 of 4
Enfamil Optimum Enspire Powder Infant Formula - 20.5oz - 1 of 4

Enfamil Optimum Enspire Powder Infant Formula - 20.5oz

13 Questions
$51.99 ($2.54/ounce)

In Stock

Eligible for registries and wish lists

At a glance

About this item

Highlights

  • PEDIATRICIAN & PARENT TRUSTED: Enfamil is the #1 trusted infant formula brand by pediatricians* making Enfamil Optimum baby formula a reliable choice for growing families. Optimum is premium baby formula for infants through 12 months of age
  • GIVE YOUR BABY OUR BEST: CHOOSE OUR SUPER BLEND! Enfamil Optimum infant formula has lactoferrin to support immune health, MFGM to support brain development and a dual prebiotic blend (2'-FL & LnNT) to support gut health. Premium nutrition & daily feedings 
  • LACTOFERRIN FOR IMMUNE SUPPORT: This breast milk-inspired formula has lactoferrin, to support your baby's developing immune system. Enfamil Optimum helps nourish your baby's immune system as part of daily infant nutrition. 
  • MFGM FOR BRAIN DEVELOPMENT: MFGM means milk fat globule membrane, made for growing minds. Enfamil Optimum is a milk-based formula has nutrients that support growth and cognitive development for growing babies through 12 months.
  • PREBIOTICS FOR GUT HEALTH SUPPORT: Our formula has ingredients found in breast milk to help support gut health. 
  • No artifical growth hormones,colors & NON-GMO: Our baby formula powder has non-GMO ingredients & does not have artificial growth hormones, colors & flavors. Enfamil Optimum has no high fructose corn syrup & has U.S.-sourced nonfat dry milk 
  • OUR CLOSEST FORMULA TO BREAST MILK: Our Super Blend has nutrients that are also found in breast milk. Enfamil Optimum is the only leading baby formula brand to have lactoferrin,an immune-supporting protein found in breast milk and colostrum. 
  • JOIN ENFAMIL FAMILY BEGINNINGS & EARN REWARDS: Sign up for Enfamil Family Beginnings to enjoy exclusive savings and expert tips - plus earn rewards with every eligible purchase 
  • CHOOSE A CASE PACK FOR ADDED CONVENIENCE: Stock up with a case pack of Enfamil formula to help ensure you're prepared for regular feedings or busy routines at home or daycare. Convenient for parents and caregivers including when packing a diaper bag.
  • This Formula provides trusted nutrition for combo feeding and supplementing breast milk.

Description

Give your baby our best: choose our Super Blend. Enfamil Optimum is our closest formula to breast milk, designed to support immune health has lactoferrin to support immune health, MFGM and DHA to support brain development & Dual prebiotic blend to support gut health
Enfamil Optimum is the only leading infant formula brand that has lactoferrin, an immune-supporting protein found in colostrum and breast milk. MFGM, found in breast milk, helps support brain development and growing minds.Enfamil Optimum has a dual prebiotic blend of 2'-FL and LnNT, ingredients also found in breast milk that help nourish baby's gut and support immune health. It has non-GMO ingredients†, Enfamil Optimum does not have artificial growth hormones*, artificial colors, and artificial flavors. It does not have high fructose corn syrup and has nonfat dry milk from the United States.
Optimum provides premium formula nutrition for babies through 12 months and can be used for everyday formula use, full-time feeding, combo feeding, supplementing breast milk, or transitioning from breastfeeding. New parents can prepare the powder with water and use infant bottles as directed to feed infants daily. Snap Eligible
*Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO

Serving Size: 5 fl oz

Amount (5 fl oz)

Calories: 100
% Daily Value*
Total Fat 5.3grm0%
Sodium 27mg0%
Total Carbohydrate 11.1grm0%
Protein 2.1grm0%
Water 133grm0%
Linoleic Acid 780mg0%
Vitamin A 3000%
Vitamin D 700%
Vitamin E 20%
Vitamin K 9mcg0%
Thiamin (B1) 80mcg0%
Riboflavin (B2) 140mcg0%
Vitamin B6 60mcg0%
Vitamin B12 0.3mcg0%
Niacin 1000mcg0%
Folic Acid (Folacin) 16mcg0%
Pantothenic Acid 500mcg0%
Biotin 3mcg0%
Vitamin C (Ascorbic Acid) 12mg0%
Choline 24mg0%
Inositol 24mg0%
Calcium 78mg0%
Phosphorus 43mg0%
Magnesium 8mg0%
Iron 1.8mg0%
Zinc 1mg0%
Manganese 15mcg0%
Copper 75mcg0%
Iodine 15mcg0%
Selenium 2.8mcg0%
Potassium 108mg0%
Chloride 63mg0%
* Percentage of Daily Values are based on a 2,000 calorie diet.

Ingredients:

nonfat milk, lactose, vegetable oil (contains one or more of the following: palm olein oil, coconut oil, soy oil, high oleic sunflower oil), whey protein concentrate (g), and less than 2%: lacto-n-neotetraose (h), 2'-fucosyllactose (h), lactoferrin, mortierella alpina oil#, schizochytrium sp, oil**, calcium carbonate, calcium phosphate, cupric sulfate, ferrous sulfate, magnesium oxide, manganese sulfate, potassium chloride, potassium citrate, potassium iodide, sodium chloride, sodium selenite, zinc sulfate, soy lecithin, choline chloride, inositol, ascorbic acid, biotin, calcium pantothenate, folic acid, niacinamide, riboflavin, thiamin hydrochloride, vitamin b12, vitamin b6 hydrochloride, vitamin d3, vitamin k1, vitamin e acetate, vitamin a palmitate, taurine, l-carnitine. (g) a source of mfgm (milk fat globule membrane composed of proteins and fast) components). (h) a source of hmo (2’-fl & lnnt human milk oligosaccharides), # a source of arachidonic acid (ara). **a source of docosahexaenoic acid (dha).

Allergens & Warnings:

Warning: Do not use a microwave oven to warm formula. Serious burns may result. Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35-40 degrees F (2-4 degrees C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within one hour or discard.
Features: Non-GMO
Dietary Needs: Naturally Flavored, Non-GMO Project Verified
Baby Formula Focus: Easy to Digest, Brain Development, Immune System Support
Base Ingredient: Milk
State of Readiness: Mix
Form: Powdered
Package Quantity: 1
Age Stage: Infant
Beverage container material: Plastic
TCIN: 50684456
UPC: 300875117484
Item Number (DPCI): 007-09-0402
Origin: Assem USA w/foreign/dom. parts
Grocery Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers. Any additional pictures are suggested servings only.
If the item details aren’t accurate or complete, we want to know about it.

Shipping details

Estimated ship dimensions: 6.063 inches length x 4.252 inches width x 5.3543 inches height
Estimated ship weight: 1.575 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest. If purchased online with SNAP EBT, this item must be returned within 90 days of the date it was shipped, delivered by a Shipt shopper, or made ready for pickup. This 90-day return window is required by SNAP.
See the return policy for complete information.

Q: Why the spoon contained in the bottle that i bought this time is different than last time?

submitted by Jason - 6 years ago

  • A: Hello! We are sorry to hear about your experience while using our Enfamil Enspire. We would like to speak with you directly about your experience with our formula! When you have a moment please give us a call at 1-800-222-9123, select option 1 and reference #604546. We look forward to speaking with you and seeing how we can help! -Kristi

    submitted byEnfamil Customer Care - 6 years ago
    Brand expert

Q: How long does the tube last--I mean "expire" . I am afraid to buy too much(6) one time and expries before baby can use all of them

submitted by Jane - 7 years ago

  • A: I appreciate your interest in our Enspire! Since retailers are responsible for maintaining their inventory you would need to reach out to Target directly to ask what their current product expiration date is. Since we are not able to see which batch of product is in Target's inventory, we are not able to provide you with the current expiration date.

    submitted byMike J - 3 years ago
    Brand expert

Q: Hi is this formula similar to breastmilk?

submitted by Monique - 6 days ago

  • A: Hi Monique! Enfamil Optimum is breast milk inspired nutrition. It has lactoferrin, one of the immune system’s supporting proteins also found in breast milk. Lactoferrin is a protein also found in breast milk and colostrum that supports the immune system. Lactoferrin is the second most abundant whey protein in human milk and helps support a healthy gut. Thank you for your great question! - Libby, Enfamil Expert

    submitted byEnfamil Customer Care - 5 days ago
    Brand expert

Q: How many grams of DHA does contain per serving?

submitted by Infant formula - 2 years ago

  • A: Thank you for your great question! Enfamil Enspire Optimum has 17 milligrams (mg) of DHA and 25 milligrams (mg) of ARA per 100 Calories (or 5 fluid ounces). We appreciate your choice of Enfamil! - Libby, Enfamil Expert

    submitted byEnfamil Customer Care - 2 years ago
    Brand expert

Q: Can I use this without supplementing breast milk because my baby won’t take to my milk anymore?

submitted by Lejla - 2 years ago

  • A: Hi Lejla! Enspire Optimum can be used as a sole or supplemental source of nutrition for the first 4 through 6 months for healthy, full-term infants and can be a major source of nutrition for the 7th through the 12th month of age. Thank you for your interest in Enspire Optimum! ~ Karen, Enfamil Expert

    submitted byEnfamil Customer Care - 2 years ago
    Brand expert

Q: What ingredients can cause allergic reaction to baby? I recently bought this formula and I ended up in the hospital with my baby

submitted by JT - 2 years ago

  • A: We have the best customers, and we thank you for being one of them JT! We appreciate you taking the time to leave us a review! If you have any questions/if we can assist you in any way in the future, please feel free to reach out to us at 1-800-222-9123, select option 1 and reference #758050. Thanks!.

    submitted byEnfamil Customer Care - 2 years ago
    Brand expert

Q: It's this formula have metallic or fish smell?

submitted by Henry - 2 years ago

  • A: Hi, Henry! The aroma of our Enspire Optimum is described as "milky, fishy, slight cardboard." I hope this information helps! ~Kate, Enfamil Expert

    submitted byEnfamil Customer Care - 2 years ago
    Brand expert

Q: Is this formula fill up baby ,like Enfamil ar?? Want closest to breast milk but a formula that is also help baby fill fuller?

submitted by Honey - 2 years ago

  • A: Hi, Honey! We would not expect your baby to feel fuller after consuming Enfamil A.R. compared to our other routine formulas, because they each have the same calories per fluid ounce when prepared according to label directions. I hope this information helps! ~Kate

    submitted byEnfamil Customer Care - 2 years ago
    Brand expert

Q: Is this formula good for constipation?

submitted by Mls - 3 years ago

  • A: Hello! Thank you for reaching out to us with your question regarding our Enspire Optimum. If you have any future questions please give us a call at 1-800-222-9123, choose option 1 and reference #3439844 and one of our friendly representatives will be happy to speak with you. Thanks! - Ron, Enfamil Expert

    submitted byEnfamil Customer Care - 3 years ago
    Brand expert

Q: is this formula lactose free?

submitted by Yanni - 4 years ago

  • A: Enfamil Enspire Optimum is not lactose-free. -Sara, Enfamil Expert

    submitted byEnfamil Customer Care - 4 years ago
    Brand expert
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Guests are saying

Enfamil Optimum is highly regarded by parents for its close resemblance to breast milk, making it an excellent choice for transitioning from breastfeeding. Many guests appreciate its gentle formulation that supports digestion and reduces fussiness in babies. The product is praised for its nutritional benefits, helping babies grow and thrive. While some guests express concerns about price increases, the overall sentiment remains positive due to the product's effectiveness and quality.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.8 out of 5 stars with 4343 reviews
    easy on tummy: 4.39 out of 5
    easy to prepare: 4.82 out of 5
    quality: 4.53 out of 5
    value: 4.05 out of 5
    86% would recommend
    114 recommendations
    5 out of 5 stars
    1 November, 2026
    originally posted on Enfamil
    Image

    (no review title)

    [This review was collected as part of a promotion.] Has been one of the best formulas that we have tried
    Imm06
    From Customer Care team
    Thank you so much for sharing your experience with our product! We truly appreciate your review and are glad you took the time to write it.
    8 days ago
    Did you find this review helpful?
    5 out of 5 stars
    30 October, 2026
    originally posted on Enfamil
    Image

    Our family love

    Both of my kids have been on Enfamil Optimum (used to be Enspire) — my daughter for a full year, my son for eight months — and I couldn't be happier. It's gentle on their tummies, they love the taste, and I trust the nutrition. Highly recommend.
    Celina
    From Customer Care team
    We truly appreciate you choosing Enfamil for each of your babies, Celina. It means so much to us! We’re so glad you’re part of our Enfamil family!
    9 days ago
    Did you find this review helpful?
    5 out of 5 stars
    28 October, 2026
    originally posted on Enfamil
    Image

    Great

    [This review was collected as part of a promotion.]
    Great product
    From Customer Care team
    Thank you so much for the 5-star review!
    14 days ago
    Did you find this review helpful?
    5 out of 5 stars
    26 October, 2026
    originally posted on Enfamil
    Image

    Great similarity to breast milk ingredients

    Baby likes this formula and he’s normally breastfeeding
    Mmanuel
    From Customer Care team
    We are so honored you chose us to help supplement your baby's feeds!
    15 days ago
    Did you find this review helpful?
    5 out of 5 stars
    25 October, 2026
    originally posted on Enfamil
    Image

    Great formula for my little one!

    I love that Enfamil Optimum (Enspire) is designed to provide important nutrients to support my baby’s growth and development. I appreciate the thought put into the ingredients, and I feel good about having a formula option I can rely on to help nourish my little one. It’s reassuring to have a trusted brand as part of my baby’s feeding journey. Definitely a formula worth considering for parents looking for a premium infant formula!
    Sierra
    From Customer Care team
    We really appreciate your thoughtful comments. Thank you so much for taking the time to share your experience with us!
    15 days ago
    Did you find this review helpful?
    1 out of 5 stars
    Thumbs down graphic, would not recommend
    21 October, 2026Verified purchase

    Not worth it, switching to similac advance

    Container is useless not air tight. Item increased nearly $20 in a couple of months. Now it’s 51.99 for a container that lasts a week! I’m switching this is ridiculous.
    MauiGirl
    From Enfamil Team team
    Hello MauiGirl! We are sorry to hear about your dissatisfaction with our Enspire Optimum and would like to get a little more information about your concerns. Please give us a call at 1-800-222-9123, choose option 1, and reference #9316495. Bev, Enfamil Expert
    15 days ago
    easy on tummy: 5 out of 5
    easy to prepare: 5 out of 5
    quality: 5 out of 5
    value: 1 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    21 October, 2026
    originally posted on Enfamil
    Image

    Great formula.

    Great formula just felt right to use this one to combo feeding my son as the ingredients are so similar to real breast milk. He did amazing on this one.
    PTVash
    From Customer Care team
    We are thrilled to be part of your son’s feeding journey! Thank you for choosing us to assist with your feeding needs.
    21 days ago
    Did you find this review helpful?
    4 out of 5 stars
    Thumbs down graphic, would not recommend
    20 October, 2026Verified purchase

    very expensive!

    price was raised by 5!! too much
    N ibrahim
    From Enfamil Customer Care team
    Thank you for taking the time to leave a review. We continually invest time and energy into cost saving initiatives to help contain costs for our consumer. However, at times, we must increase our prices to ensure we continue to bring high quality, innovative products and services to the marketplace. We do not take regularly scheduled pricing actions and only pass along cost increases when it is absolutely necessary.
    22 days ago
    Did you find this review helpful?
    5 out of 5 stars
    19 October, 2026
    originally posted on Enfamil
    Image

    Enfamil Optimum

    My baby loves Enfamil Optimum! Packaging is great too!
    RoseHenny
    From Customer Care team
    We appreciate you taking the time to share your experience with us. Thank you for choosing Enfamil to help give your little one the best start in life!
    20 days ago
    Did you find this review helpful?
    4 out of 5 stars
    13 October, 2026Verified purchase

    (no review title)

    Why did they raise their price $5 in the past week?
    Nikki S
    From Enfamil Customer Care team
    We apologize for the inconvenience, but all prices are subject to change without notice. We do provide promotions and special offers through our Enfamil Family Beginnings program and will be happy to check the status of your enrollment and determine if we have any current offers. To learn about special programs we have for this product, please call us at 1-800-222-9123.
    29 days ago
    Did you find this review helpful?
    5 out of 5 stars
    12 October, 2026
    originally posted on Enfamil
    Image

    Great Product!

    [This review was collected as part of a promotion.] This product is so close to breast milk! My baby loves it!
    B2026
    From Customer Care team
    Thanks for your review!
    28 days ago
    Did you find this review helpful?
    5 out of 5 stars
    12 October, 2026
    originally posted on Enfamil
    Image

    Good quality formula

    Good quality formula and doesn't taste too bad I tired some just to make sure.
    Bm987
    From Consumer Care Nutrition team
    Hello Bm987! We are sorry to hear about your dissatisfaction with our Enfamil Enspire Optimum and would like to get a little more information about your concerns. Please give us a call at 1-800-222-9123, choose option 1, and reference #9258530. Thanks! Shekinah, Enfamil Expert
    28 days ago
    Did you find this review helpful?
    5 out of 5 stars
    12 October, 2026
    originally posted on Enfamil
    Image

    ⭐️⭐️⭐️⭐️⭐️

    [This review was collected as part of a promotion.] I absolutely love Enfamil! It gives me peace of mind knowing my baby is getting the nourishment she needs. I appreciate the quality of their products and how much they care about supporting babies and parents. As a mom, finding a brand I feel comfortable trusting is so important, and Enfamil has been a great choice for us. I would definitely recommend Enfamil to other parents looking for quality baby formula. Thank you, Enfamil, for being a brand that parents can turn to for their little ones! 💕🍼
    Ruby
    From Customer Care team
    Thank you so much for sharing your experience with us, Ruby! We truly appreciate your review and are glad you took the time to write it.
    28 days ago
    Did you find this review helpful?
    5 out of 5 stars
    8 October, 2026Verified purchase

    (no review title)

    Shocked they just raised the price $5
    Nikki
    From Enfamil Customer Care team
    We appreciate you taking the time to leave a 5-star review! While we continually invest time and energy into cost-saving initiatives, from time to time it is necessary to increase our prices to enable us to live up to our commitment to bring high-quality, innovative products and services to the marketplace. We appreciate your understanding regarding the price increases. We do not take regularly scheduled pricing actions. Rather, we only pass along cost increases when it is absolutely necessary. To learn about special programs we have for this product, please call us at 1-800-222-9123.
    1 month ago
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    8 October, 2026
    originally posted on Enfamil
    Image

    Great formula

    [This review was collected as part of a promotion.] This product works so well we used this as well as the gentlease
    Sami
    From Consumer Care Nutrition team
    Hi Sami! Thank you for choosing Enfamil Enspire Optimum! We appreciate your feedback and would like to learn more about your child's experience using our formula. Please give us a call at 1-800-222-9123, choose option 1 and reference #9249609. Thanks! Sheila -Enfamil Expert
    29 days ago
    Did you find this review helpful?
    5 out of 5 stars
    6 October, 2026
    originally posted on Enfamil
    Image

    Love this milk

    Great since I actually breastfeed too my baby loves it so I’m happy
    Baby milk
    From Customer Care team
    We are so honored you chose us to help supplement your baby's feeds!
    1 month ago
    Did you find this review helpful?
    5 out of 5 stars
    3 October, 2026
    originally posted on Enfamil
    Image

    Breastfeeding Mom

    [This review was collected as part of a promotion.] Second baby we’ve used Optimum with and we have never had any issues. Both babies love it and it’s close to my breastmilk so no belly issues.
    Hale
    From Customer Care team
    We truly appreciate you choosing Enfamil for each of your babies, Hale. It means so much to us! We’re so glad you’re part of our Enfamil family!
    1 month ago
    Did you find this review helpful?
    5 out of 5 stars
    3 October, 2026
    originally posted on Enfamil
    Image

    The best for my newborn

    Enfamil Optimum has been the best formula for our baby so far. He seems to digest it well, has less fussiness, and overall seems more comfortable after feedings. Definitely a formula we’re happy with!
    neil
    From Consumer Care Nutrition team
    Hello Neil! We are thrilled to hear that your little one is doing well while using our Enfamil Enspire Optimum. If you have any questions/if we can assist you in any way in the future, please feel free to reach out to us at 1-800-222-9123, select option 1 and reference #9226443. Thanks! Sheila– Enfamil Expert
    1 month ago
    Did you find this review helpful?
    5 out of 5 stars
    3 October, 2026
    originally posted on Enfamil
    Image

    Great ingredients

    [This review was collected as part of a promotion.] I got this as a gift and it is one of the best on the market
    Whit
    From Customer Care team
    What a great review! Thanks so much for making our day!
    1 month ago
    Did you find this review helpful?
    5 out of 5 stars
    2 October, 2026
    originally posted on Enfamil
    Image

    Loved!

    [This review was collected as part of a promotion.] My baby used this formula until he was 9 months old, I loved the benefits and added ingredients that mimic real breast milk!
    Sam21
    From Customer Care team
    We appreciate you taking the time to share your experience with us. Thank you for choosing Enfamil to help give your little one the best start in life!
    1 month ago
    Did you find this review helpful?

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