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Differin 10% Benzoyl Peroxide Acne Spot Treatment: Hypoallergenic, Facial Treatment, Gel, Acne-Prone Skin - 2 of 4Differin 10% Benzoyl Peroxide Acne Spot Treatment: Hypoallergenic, Facial Treatment, Gel, Acne-Prone Skin - 3 of 4Differin 10% Benzoyl Peroxide Acne Spot Treatment: Hypoallergenic, Facial Treatment, Gel, Acne-Prone Skin - 4 of 4
Differin 10% Benzoyl Peroxide Acne Spot Treatment: Hypoallergenic, Facial Treatment, Gel, Acne-Prone Skin - 1 of 4

Differin 10% Benzoyl Peroxide Acne Spot Treatment: Hypoallergenic, Facial Treatment, Gel, Acne-Prone Skin

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At a glance

About this item

Highlights

  • MAXIMUM STRENGTH 10% BENZOYL PEROXIDE: One 1 oz tube of Differin Acne Spot Treatment with 10% benzoyl peroxide as the strongest over-the-counter (OTC) concentration to visibly reduce acne size and redness after 1 use.
  • FAST BLEMISH SPOT TREATMENT: Penetrates deep into pores and works to immediately kill acne-causing bacteria
  • FOUR-IN-ONE ACNE TREATMENT FOR FACE: Acne solution that treats imperfections, prevents acne, targets acne-causing bacteria, and improves skin texture
  • FORMULATED WITH GLYCERIN: While benzoyl peroxide starts clearing acne blemishes, glycerin helps to minimize dryness
  • ACNE SPOT TREATMENT: Acne treatment for face and body use, developed for acne-prone skin

Description

Differin 10% Benzoyl Peroxide Spot Treatment is an acne treatment for face and body use, developed for acne-prone skin. This four-in-one solution treats acne, prevents acne, kills acne-causing bacteria, and improves skin texture. Formulated with 10% benzoyl peroxide, the strongest OTC concentration without a prescription, and glycerin to minimize dryness, it immediately targets acne-causing bacteria and effectively prevents imperfections. This multi-action pimple cream clears and treats acne, whiteheads, blackheads, and clogged pores, visibly reducing size and redness after first use. Use as part of your skincare routine to treat and clear acne and other imperfections. After cleaning with a facial cleanser, apply on dry skin directly on affected areas. Follow up with a moisturizer and SPF in the morning and night cream at night. Reapply as needed. Dry skin may occur while using this product, so start with one application daily and gradually increase it if needed.Key Ingredient:Benzoyl Peroxide
Scent: Unscented
Trial/Mini/Travel Size: Yes
Health Facts: Hypoallergenic, Paraben-Free, Artificial Fragrance-Free
Product Form: Gel
Disposability: Do not flush
Primary Active Ingredient: Benzoyl Peroxide
Package Quantity: 1
Beauty Purpose: Sensitive Skin, Dry, Pore Cleansing
Recommended Skin Type: Acne-Prone
Net weight: 1 fl oz (US)
Features: Safe to Use On Sensitive Skin, Lightweight, Non-Comedogenic
TCIN: 91370206
UPC: 302994611003
Item Number (DPCI): 037-12-4525
Origin: Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
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Active ingredients

benzoyl peroxide' '10.0%

Purpose

Acne treatment

Uses

Use For the treatment of acne

Directions

Directions Sensitivity Test for a New User. Apply product sparingly to one or two small affected areas during the first 3 days. If no discomfort occurs, follow the directions stated below, clean the skin thoroughly before applying this product, cover the entire affected area with a thin layer one to three times daily, because excessive drying of the skin may occur, start with one application daily, then gradually increase to two or three times daily if needed or as directed by a doctor, if bothersome dryness or peeling occurs, reduce application to once a day or every other day, if going outside, apply sunscreen after using this product. If irritation or sensitivity develops, stop use of both products and ask a doctor

Inactive ingredients

inactive ingredients acrylates copolymer, carbomer, diethylhexyl sodium sulfosuccinate, disodium edta, glycerin, poloxamer 182, propylene glycol, silica, sodium hydroxide, water

Shipping details

Estimated ship dimensions: 1.73 inches length x 2.72 inches width x 6.35 inches height
Estimated ship weight: 0.42 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Q: Is this product suitable for sensitive skin?

submitted by AI Shopping Assistant - 3 months ago

  • A: Yes, it is dermatologist tested and safe to use on sensitive skin.

    submitted byAI Shopping Assistant - 3 months ago
    Ai generated

Q: What additional benefit does glycerin provide in this product?

submitted by AI Shopping Assistant - 3 months ago

  • A: Glycerin helps to minimize dryness while benzoyl peroxide clears acne blemishes.

    submitted byAI Shopping Assistant - 3 months ago
    Ai generated

Q: How often should I apply this treatment for best results?

submitted by AI Shopping Assistant - 3 months ago

  • A: Start with one application daily and gradually increase as needed depending on skin tolerance.

    submitted byAI Shopping Assistant - 3 months ago
    Ai generated

Q: How does Differin treatment target acne-causing bacteria?

submitted by AI Shopping Assistant - 3 months ago

  • A: It penetrates deep into pores and works to kill acne-causing bacteria effectively.

    submitted byAI Shopping Assistant - 3 months ago
    Ai generated

Q: Can this treatment be used on areas other than the face?

submitted by AI Shopping Assistant - 3 months ago

  • A: Yes, it is designed for both face and body use for acne treatment.

    submitted byAI Shopping Assistant - 3 months ago
    Ai generated

Q: Do I have to wash this off after a certain of using it?

submitted by Angel - 6 months ago

  • A: Hey Angel, Great question! We recommend to wash your face 2x a day and apply the Differin 10% Benzoyl Peroxide Acne Spot Treatment on dry skin, directly on the affected areas. For real-time answers to all your beauty questions, use the “Chat with a Virtual Beauty Consultant” button on any beauty product page. https://www.target.com/c/beauty/-/N-55r1x

    submitted byTarget Beauty Consulting - 6 months ago
    Brand expert

Q: Can I use on entire face? I have a lot of pop up pretty much all over and don’t want to get it if it only is for small areas.

submitted by Its alright - 10 months ago

  • A: Great question! It should be applied directly to individual blemishes rather than all over the face. While some people may use it on a wider area, it's generally not recommended for full-face application due to the potential for excessive dryness and irritation. For real-time answers to all your beauty questions, use the “Chat with a Virtual Beauty Consultant” button on any beauty product page.

    submitted byTarget Beauty Consulting - 10 months ago
    Brand expert

Q: is this spot treatment safe to use while nursing?

submitted by saddeypassey - 1 year ago

  • A: Hey, Women who are pregnant or breastfeeding should check with their physician before using any new skincare products. For all your future beauty questions, get real-time answers using the “Chat with a Virtual Beauty Consultant” button, found on every product page.

    submitted byTarget Beauty Consulting - 1 year ago
    Brand expert

Q: Will this help the most for people who have HS?

submitted by Betty wu - 2 years ago

  • A: Hi @username! Our Maximum Strength Acne Foaming Cleanser with 10% Benzoyl Peroxide cleanses the skin with a dual action formula that starts working immediately to help eliminate 99.99% of acne causing bacteria in 15 seconds! Benzoyl peroxide is an acne-fighting ingredient that prevents the buildup of bacteria that causes acne deep in the pores. It’s recommended more often by derms than salicylic acid and sulfur. However, we recommend reaching out to your dermatologist to find products that work for your specific skin type and needs. We hope this helps!

    submitted byGalderma Team Member - 2 years ago
    Brand expert

Q: Can I apply this over a clean face with moisturizer? Or should I do it without the layer of moisturizer

submitted by Molly - 3 months ago
See all questions (10)

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Guests are saying

The Differin 10 BPO Spot Treatment has garnered positive feedback for its effectiveness in reducing acne and blemishes quickly. Many guests appreciate its lightweight texture and minimal scent, making it easy to incorporate into their skincare routines. While some users experienced dryness or irritation, most found that using a small amount yielded significant results. This product is particularly praised for its ability to clear stubborn pimples overnight, making it a go-to solution for acne-prone skin.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.5 out of 5 stars with 342 reviews
    effectiveness: 4.11 out of 5
    quality: 4.24 out of 5
    value: 4.47 out of 5
    72% would recommend
    18 recommendations
    5 out of 5 stars
    16 May, 2026Verified purchase

    Kick acnes butt!

    I absolutely love this acne products! They’ve helped improve my skin so much without being overly harsh or drying. My skin feels cleaner, smoother, and I’ve noticed a real difference in breakouts after using them consistently. One of the best parts is being able to use my FSA/HSA card right at the register, which makes buying skincare so much easier and more affordable. Great quality products at a reasonable price — definitely worth trying if you struggle with acne!
    Tabitha
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    12 May, 2026Verified purchase

    (no review title)

    I LOVE this cream! I get pimples here and there, and I can always rely on this cream for them to be gone in 2-3 days. I put a thick layer on each pimple at night, and if I’m trying to get it down faster, I apply in the morning as well before my lotion. Really helps just bring bumps down, and stops my pimples with white dots from leaving scars.
    Michelle
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    24 April, 2026
    originally posted on influenster.com
    Image

    Works wonders on cystic acne

    This product has helped so much with my hormonal acne on my face and back. It clears it up and reduces redness and inflammation within a day. The only thing is it is drying to the skin, but it's to be expected. I just focus on moisturizing while using this product.
    MaggieD
    Did you find this review helpful?
    5 out of 5 stars
    15 April, 2026
    originally posted on differin.com
    Image

    HOLY GRAIL

    Saved my skin in a matter of weeks!!! I have suffered with acne for a long time but this the best my skin has looked in about 2 years.
    MJ06741
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    14 April, 2026

    (no review title)

    Worked but acne came back
    Alison
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    4 out of 5 stars
    Thumbs up graphic, would recommend
    24 March, 2026Verified purchase

    (no review title)

    The first time I used this it caused a lot of irritation on my face, however I did try it again and used it much more sparingly and had great results. A little goes a LONG way, so start with a small (pea size) amount and be sure to moisturize after (the CeraVe Intensive Cream saved me). It still causes dryness and some redness where I apply, but it definitely reduces the pimple (quickly!!) and can be paired with a good moisturizer to minimize this effect.
    ally
    effectiveness: 5 out of 5
    quality: 4 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    23 March, 2026

    perfect product

    perfect product no irritation and works quick and well, also great price.
    Kevin
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    4 out of 5 stars
    17 February, 2026
    originally posted on influenster.com
    Image

    Helps get acne smaller and less red

    I've been using this for a few days now and I think it is helping. I've paired it with panoxyl face wash for a new routine in hopes of finally cleaning my stubborn acne. My face is less bumpy and my acne spots are smaller but they are still there. I'm going to stick with it because I do see a difference and I know it can takes while. Redness is the same, maybe a little less. It is a little drying from the combo of acne wash and this cream but not too bad.
    emilyh1610
    Did you find this review helpful?
    4 out of 5 stars
    13 December, 2025

    (no review title)

    It very good for getting rid of acne and is a go to treatment just be careful to not use it to much it could lead to peeling or really dry skin but love.
    Hannah
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    2 guests found this review helpful. Did you?
    5 out of 5 stars
    24 November, 2025
    originally posted on influenster.com
    Image

    Reduced spots so quick!

    [This review was collected as part of a promotion.] Okay so I was super skeptical about this at first because I’ve tried literally everything for my random pimples and nothing really works. But wow, this stuff is actually magic. I put it on a stubborn spot at night and literally by the next morning it was way smaller and way less red. The texture is a little thick but it doesn’t feel gross or sticky, and it dries down nicely so I can put my moisturizer over it without any weird feeling. I’ve been using it for a couple of weeks now and my breakout spots don’t last nearly as long, which is honestly life changing. This is officially my go to “emergency zit zapper” and I tell anyone with annoying pimples to give it a try because it actually works.
    nestorpi_1877
    2 guests found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    4 November, 2025Verified purchase

    Works Great!!

    Holy Cow this stuff works! I have been having a hard time getting rid of acne and nothing was seem to get rid of it. I did some research and found this stuff and thought I would give it a try! Day one I noticed a difference, day I went to put more on before bed and could barely see my acne. I am very pleased and will be using/buying again!! It does leave some white residue like past reviews say, but comes off very easily with a baby wipe. Only thing I didn't like, was that in came in a big box for a small tube, waste of space and packaging, but my only complaint
    Lorelai
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 4 out of 5
    2 guests found this review helpful. Did you?
    5 out of 5 stars
    28 October, 2025
    originally posted on differin.com
    Image

    Finally an Acne Product that is AMAZING!!

    People Differen is the ULTIMATE Acne treatment a reasonably cheap product that works EFFICIENTLY and QUICKLY!! I had an Acne problem a blind pimple near my temple that wouldn't go away! From Day 2 of Differen it got rid of swelling pain redness!! Try this product! 5 Stars!!
    Cousinbrucie
    1 guest found this review helpful. Did you?
    4 out of 5 stars
    25 October, 2025
    originally posted on influenster.com
    Image

    Great!!

    [This review was collected as part of a promotion.] This was actually such a good product, unfortunately I downloaded the app again just recently so I don’t have the product anymore to take a picture of. Overall I loved it, packaging was good and it worked super well!
    nicolebeau_4329
    Did you find this review helpful?
    4 out of 5 stars
    20 October, 2025Verified purchase

    (no review title)

    This spot treatment worked so good for my skin. I have been breaking out and this has been a life saver. Didn’t have any reactions or issues but for first time use definitely go slow
    Jaylyn
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    14 October, 2025Verified purchase

    rid of allergic rash on my face

    this cream got rid of my allergic reaction rash on my face! I wish it had a thinner consistency so I felt better about layering hydrating serums on top, but it’s not a dealbreaker. def repurchasing for a lifetime
    F
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    12 October, 2025
    originally posted on influenster.com
    Image

    Great for acne

    [This review was collected as part of a promotion.] This was very effective in improving my acne. It was safe for my sensitive skin. No scent. It seems to be a good value for the money. Minimalistic packaging.
    anndreso_5549
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    8 September, 2025Verified purchase

    Amazing!!

    This has helped with my acne espeically for random flare ups. I apply it at night and in the morning it is diminished.
    Raquel
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    3 out of 5 stars
    5 August, 2025
    originally posted on influenster.com
    Image

    Not worth it

    [This review was collected as part of a promotion.] I have stubborn acne and was excited to try this product. It did not help that much. It mostly just dried out my skin and left hard to get rid of acne spots.
    michellez91_4001
    4 guests found this review helpful. Did you?
    3 out of 5 stars
    15 June, 2025
    originally posted on influenster.com
    Image

    Indifferent

    [This review was collected as part of a promotion.] The product added dryness to the area it was applied on reducing the redness and bump of zits on my face but it did not completely remove a breakout. I think I’d stick with elf zit patches over this.
    isabellam162_8350
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    28 May, 2025
    originally posted on influenster.com
    Image

    It works!

    [This review was collected as part of a promotion.] Did a great job with smaller blemishes, didn’t irritate my skin, and a little bit goes a long way! Simple easy to read instructions on packaging. And you get a good amount of product for the price. Didn’t notice too much of a smell, and it didn’t bother my sensitive nose.
    cassyc1_4811
    Did you find this review helpful?

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