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Acetaminophen & Aspirin (NSAID) Added-Strength Pain Reliever Caplets - up&up™
$6.79 ($0.02/count)
In Stock
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About this item
Highlights
- Packaging may vary. Same trusted quality
- Pain reliever caplets contain acetaminophen, aspirin and caffeine
- Helps to relieve headache and migraine pain, as well as muscle aches and other pain
- Compare to the active ingredients in Excedrin Extra Strength
Description
Go through your day with relief from headaches and other pains with the help of the Acetaminophen and Aspirin Added-Strength Pain Reliever Caplets from up&up™. With a combination of acetaminophen, aspirin and caffeine, you'll find quick relief from throbbing headaches or migraines. With each pain relief caplet, you can relieve the pain caused by muscle aches and menstrual cramps as well headache pain. The added caffeine helps to relax muscle contractions and improve mental altertness as you head off to work or spend time with loved ones.
We believe making smart choices for the people, places, and pets in your life should be easy and affordable. And, having quality you can trust should be a given. That’s why you can count on our promise – caring for your everyday in every way.
Satisfaction guaranteed – Love it or your money back.
We believe making smart choices for the people, places, and pets in your life should be easy and affordable. And, having quality you can trust should be a given. That’s why you can count on our promise – caring for your everyday in every way.
Satisfaction guaranteed – Love it or your money back.
Suggested Age: 12 Years and Up
Health Facts: Contains Acetaminophen, Contains Aspirin, Contains Caffeine
Active Ingredient Strength Value: 250 Milligrams
Product Warning: Consult a doctor if you have heart disease, Contains Acetaminophen, do not use if you have a bleeding problem, not for children under the age of 12, consult a doctor if you have high blood pressure, do not use if you have kidney disease, Contains Caffeine, do not use if you are pregnant
Product Form: Caplet
Primary Active Ingredient: Acetaminophen
Package Quantity: 275
TCIN: 11004687
UPC: 349483370720
Item Number (DPCI): 094-01-0124
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.
Active ingredients
acetaminophen' '250.0mg aspirin (nsaid*) *nonsteroidal anti-inflammatory drug' '250.0mg caffeine' '65.0mg
Purpose
Pain reliever Pain reliever Pain reliever aidUses
Uses Temporarily relieves minor aches and pains due to: headache a cold arthritis muscular aches toothache premenstrual and menstrual crampsDirections
Directions do not use more than directed drink a full glass of water with each dose adults and children 12 years of age and over: take 2 caplets every 6 hours; not more than 8 caplets in 24 hours children under 12 years: ask a doctorOther information
Other information store at 20°-25°C (68°-77°F); excursions permitted between 15°-30°C (59°-86°F) use by expiration date on packageInactive ingredients
carnauba wax, colloidal silicon dioxide, hypromellose, microcrystalline cellulose, mineral oil, povidone, pregelatinized starch, sodium starch glycolate, stearic acid, titanium dioxide' '
Shipping details
Estimated ship dimensions: 2.32 inches length x 2.37 inches width x 5.28 inches height
Estimated ship weight: 0.54 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 365 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup.
See the return policy for complete information.
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Guests are saying
Guests find this headache relief medication to be an effective and affordable alternative to name brands like Excedrin. It works well for migraines, toothaches, and general pain relief. However, some guests have reported issues with the taste and smell of the pills, as well as occasional stomach discomfort.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.7 out of 5 stars with 1464 reviews
quality: 4.35 out of 5
value: 4.56 out of 5
84% would recommend
144 recommendations
1 out of 5 stars
11 October, 2025Verified purchase
Not good
This has nearly doubled in price the last couple of years —- used to be 1.99. Corporate greed unhinged
5 out of 5 stars
Thumbs up graphic, would recommend
29 September, 2025Verified purchase
Works fast on my migraines!
This is an excellent generic form of the name brand medication at a fraction of the price and works fast on my migraines. Great product, convenient packaging, and readily available for both pick up and shipping.
5 out of 5 stars
Thumbs up graphic, would recommend
2 September, 2025Verified purchase
The only over-the-counter migraine medication that works for me
One of the very few migraine medications that actually work for me that’s over the counter. I get pretty bad migraines regularly and take prescription medications for them. But for minor migraines, I try to take Tylenol or Advil migraine and those never usually work except this. I was surprised how well it worked for me.
5 out of 5 stars
Thumbs up graphic, would recommend
14 August, 2025Verified purchase
Awesome brand
Works just as great as the on brand (Excedrin), if not better than it!
5 out of 5 stars
Thumbs up graphic, would recommend
20 July, 2025
Great price compared to name brand and just as wffective
Just as good as the name brand. I had a bad tension headache but opted for these rather than the ones specifically for tension because these had aspirin in them. They worked quickly for my headache which was in a band across my forehead from temple to temple.
5 out of 5 stars
Thumbs up graphic, would recommend
7 July, 2025
Works great for migraines
I buy this instead of Excedrine migraine and it works great for me! I have purchased this specific product many times and it always works very well. The price is unbeatable in comparison.
4 out of 5 stars
6 May, 2025Verified purchase
Honest review
This does work, but only depending on how severe your migraines are. If really bad, this won’t make it go away, only reduce it. If yours are minor, then it works. My migraines vary in severity depending on weather and season. The cost is obviously a huge difference from Excedrin so I deal with it. I have never had any stomach issues like other reviews mention.
5 out of 5 stars
Thumbs up graphic, would recommend
20 April, 2025Verified purchase
Works great!
This stuff is nothing sort of amazing. Not only is it affordable, it works fast on killer headaches and relieves other body aches.
1 out of 5 stars
Thumbs down graphic, would not recommend
9 April, 2025
Dont recommend
Caused stomach pains and made me throw up after taking
5 out of 5 stars
Thumbs up graphic, would recommend
23 March, 2025Verified purchase
Works great!
I always buy the Up and Up brand for medications. Work just like the name brand for a fraction of the price!
2 out of 5 stars
22 March, 2025Verified purchase
Not a good generic for me
This generic brand didn’t work for me. It took several hours before I had slight relief. I’ve taken generic Excedrin brands before but this one doesn’t work for me…too bad. Seems some others have had similar results.
5 out of 5 stars
Thumbs up graphic, would recommend
8 March, 2025Verified purchase
Headache be gone !!!!
These are just like Excedrin and makes the headach go away
1 out of 5 stars
Thumbs down graphic, would not recommend
28 January, 2025
Useless
If you suffer from *true* migraines then don’t waste any time or money on these and stick to excederin.
5 out of 5 stars
Thumbs up graphic, would recommend
5 January, 2025Verified purchase
love!!
love and way cheaper than the alternative
5 out of 5 stars
Thumbs up graphic, would recommend
25 December, 2024Verified purchase
Necessity!
These are the only thing that work for my headaches. Glad they make a generic, target offers a good price compared to name brand.
5 out of 5 stars
Thumbs up graphic, would recommend
25 December, 2024Verified purchase
"Excedrin-Level Relief Without the Excedrin Price - Try Up & Up!
Comparable to Excedrin Extra Strength at a much better price. I've been pleasantly surprised by how well these Up & Up pain relievers work. They're my go-to for headache relief and haven't failed me yet. They provide the same relief as the more expensive Excedrin, so I'll definitely be sticking with these from now on.
5 out of 5 stars
Thumbs up graphic, would recommend
8 December, 2024Verified purchase
Works just as well as name brand
Works fine! Don’t waste your money on name brand meds.
5 out of 5 stars
Thumbs up graphic, would recommend
22 November, 2024Verified purchase
Helps sometimes
I’ve suffered from migraines since I was 17 and unfortunately my son gets them as well. This is one of only two medicines that helps both of us. If we take it as soon as the migraine starts, it definitely helps. I will say that for a more severe one, we both have to use something else but overall I think it’s worth a try for migraine sufferers. Also, it’s a great price!
1 out of 5 stars
Thumbs down graphic, would not recommend
18 November, 2024Verified purchase
Dont recommend
Does not work as well as excedrin and headache did not go away
5 out of 5 stars
Thumbs up graphic, would recommend
13 November, 2024Verified purchase
Headache gone!
This works just as well as name brand products. Save yourself some money and use this! No brainer!