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Acetaminophen Extra Strength Pain Reliever & Fever Reducer Caplets - up&up™ - 2 of 3Acetaminophen Extra Strength Pain Reliever & Fever Reducer Caplets - up&up™ - 3 of 3
Acetaminophen Extra Strength Pain Reliever & Fever Reducer Caplets - up&up™ - 1 of 3

Acetaminophen Extra Strength Pain Reliever & Fever Reducer Caplets - 50ct - up&up™

26 Questions
$1.19 ($0.02/count)

In Stock

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With Target Circle™ Card (restrictions apply)

At a glance

About this item

Highlights

  • Packaging may vary. Same trusted quality
  • Extra-strength caplets provide pain relief and reduce fevers
  • Contains 500mg of acetaminophen per caplet
  • Compare to the active ingredient in Extra Strength Tylenol caplets

Description

Get back to feeling like you with the Acetaminophen Extra-Strength Pain Reliever & Fever Reducer Caplets from up&up™. The extra-strength caplets are made to target symptoms of the common cold, arthritis, backaches, toothaches, menstrual cramps and more. Keep it in your medicine cabinet for all those aches and pains that can crop up throughout your week. Compare to the active ingredient in Extra Strength Tylenol caplets.

We believe making smart choices for the people, places, and pets in your life should be easy and affordable. And, having quality you can trust should be a given. That’s why you can count on our promise – caring for your everyday in every way.

Satisfaction guaranteed – Love it or your money back.
Suggested Age: 12 Years and Up
Health Facts: Contains Acetaminophen
Active Ingredient Strength Value: 500 Milligrams
Product Warning: Do not use if you are pregnant or nursing, Contains Acetaminophen
Product Form: Caplet
Primary Active Ingredient: Acetaminophen
Package Quantity: 50
TCIN: 11369393
UPC: 349483341058
Item Number (DPCI): 094-01-0646
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Active ingredients

acetaminophen' '500.0mg

Purpose

Pain reliever/fever reducer

Uses

Uses temporarily relieves minor aches and pains due to: headache the common cold backache minor pain of arthritis toothache muscular aches premenstrual and menstrual cramps temporarily reduces fever

Directions

Directions do not take more than directed adults and children 12 years and over take 2 caplets (1,000 mg) every 6 hours while symptoms last do not take more than 6 caplets (3,000 mg) in 24 hours, unless directed by a doctor do not use for more than 10 days unless directed by a doctor children under 12 years ask a doctor

Other information

Other information SODIUM FREE store at 25°C (77°F) excursions permitted between 15°-30°C (59°-86°F) use by expiration date on package

Inactive ingredients

hypromellose, mineral oil, povidone, pregelatinized starch, sodium starch glycolate*, stearic acid, titanium dioxide [*may contain this ingredient]

Shipping details

Estimated ship dimensions: 3.7 inches length x 1.9 inches width x 1.7 inches height
Estimated ship weight: 0.1 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 365 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Q: Can you please confirm from the manufacturer whether the NEW version of this product (Extra Strength) is gluten free? If so, why no longer say it on the label? Is it now made on shared equipment? The ingredients changed when the GF label was dropped.

submitted by CDMom - 6 years ago

  • A: This is not gluten-free when the label GF label is missing. Because the ingredients (sodium starch glycolate*) can be made with wheat. I think we will have to check each bottle now in the store.

    submitted byBiastar - 4 years ago

  • A: Ok, so it's still gluten free. But CDMom also asked why does it no longer say gluten free on the label?

    submitted byNina - 5 years ago

  • A: I love (sarcasm) all these people who find the questions about the gluten free status of this product to be "Not helpful". Lucky you don't have to be concerned.

    submitted byNina - 5 years ago

  • A: NOT GLUTEN FREE contains GLUTEN - confirmed by calling 800.910.6874. For CELIACS -- BE AWARE!

    submitted byCeliacx4 - 1 year ago

  • A: Hi CDMom - We're glad you asked. This product is gluten free. Thanks for stopping by! - Alli

    submitted byAlli - 6 years ago
    Target staff support

  • A: From someone with severe celiac disease - this item NOT gluten free.

    submitted byJBeat - 3 years ago

Q: Does the product contain have any active and inactive ingredients that are sourced from animals or insects or sea food ?? Wanted to make sure if it is good for vegans ?

submitted by Digen - 5 years ago

  • A: Hi Digen - We appreciate your inquiry. There are no active and inactive ingredients that are sourced from animals or insects or sea food. We hope you find this helpful. - LeAnn

    submitted byLeAnn - 5 years ago
    Target staff support

  • A: I am confused someone from chat said this product is not suitable for vegan - when there is no animal ingredients then how is it not suitable for vegans - Please clarify, please double check this for us - thank you heaps

    submitted byPain killer - 5 years ago

Q: Is this product gluten free

submitted by Harry - 7 years ago

  • A: I've gotten the Up&Up brand before and it says Gluten Free on the bottle. I ordered the 500 count this time and it does not say Gluten Free anywhere on the bottle.

    submitted bySophie - 7 years ago

  • A: NO, it is no longer gluten free confirmed 10/18/2025.

    submitted byCeliacx4 - 1 year ago

  • A: Hi Harry - Good question! This pain reliever is gluten free. Thanks for asking. - Alli

    submitted byAlli - 7 years ago
    Target staff support

Q: I’m unable to open the lid despite having used these before. I’m pressing hard and twisting birthday it’ll just not open. How can it be fixed!? I still have more than 1/2 the bottle!

submitted by Penguin - 2 years ago

  • A: Hello - We appreciate your interest in this item. Please contact our guest services for assistance, you can contact them at-800-591-3869. – Jacob

    submitted byJacob - 2 years ago
    Target staff support

Q: Is it normal feeling super drowsy after taking it?

submitted by Jul - 4 years ago

  • A: Hello Jul - We advise you to consult your doctor with your symptoms. They will be able to help determine what is normal and safe for you. We hope you have a nice day. - Carissa

    submitted byCarissa - 4 years ago
    Target staff support

  • A: I took these while on holiday from the UK. I thought they worked better than our paracetamol but they did make me really drowsy. I needed rest so wasn't complaining!

    submitted byHelen M - 4 years ago

Q: Can these tabs be broken in half? (I only want 75% of two tab dose.) Are the tabs indented for easy breakage? Thanks for your response.

submitted by Shelley - 5 years ago

  • A: These tablets are not intended for easy and equal breakage as these tablets are not scored. It is not recommended to break the tablets, however you can check with a pharmacist for additional information.

    submitted byLorin - 5 years ago
    Target staff support

  • A: If you have a pill cutter, cutting this pill in half is very easy!

    submitted byAlice - 3 years ago

Q: WHAT IS THE COUNTRY OF ORIGIN?

submitted by KC - 7 years ago

  • A: Why does the country of origin matter? Other countries have even stricter drug laws than the US.

    submitted byAnnieM - 7 years ago

  • A: Hi, Thank you for your question about Up & Up Acetaminophen Caplets. This product is manufactured in the United States. According to government labeling specifications, if a product is manufactured outside the US, it must be documented on the labeling. If you would like additional information, please let us know and we would be happy to further assist you.

    submitted bythe Supplier - 7 years ago
    Brand expert

Q: Is this product gluten free in 2025 or 2026

submitted by sss - 10 months ago

  • A: I have celiac and can confirm it’s not gluten free. I wish target would remove the Q&A with old/ inaccurate info.

    submitted byMarie - 4 months ago

Q: If this item is gluten free, why was the gluten free label taken off? Just because something doesn't list wheat, barley, or rye in the ingredients doesn't mean it wasn't cross-contaminate with gluten.

submitted by BeaHou - 2 years ago

  • A: Hello BeaHou - Thank you for your Question! The Acetaminophen Extra Strength Pain Reliever & Fever Reducer Caplets - up&up™ is gluten free. We would love to help you out with questions or comments and we request you to call Guest Services at 1-800-910-6874. Have a great day! - Eram

    submitted byEram - 2 years ago
    Target staff support

Q: Is the current version gluten free?

submitted by gfky - 2 years ago

  • A: Hi gfky - Thank you for the inquiry about Acetaminophen Extra Strength Pain Reliever & Fever Reducer Caplets - up&up™. This pain reliever is gluten free. Hope this helps! - Rolex

    submitted byRolex - 2 years ago
    Target staff support
See all questions (26)

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Guests are saying

This acetaminophen product offers effective pain relief comparable to name brands at a fraction of the cost, making it a budget-friendly choice for guests. Many appreciate its ability to alleviate headaches, joint pain, and menstrual cramps, while the easy-to-swallow caplet form adds to its appeal. Despite some concerns about pill variations and effectiveness for certain individuals, the overall consensus highlights its value and reliability for everyday use.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.8 out of 5 stars with 3762 reviews
    quality: 4.53 out of 5
    value: 4.68 out of 5
    87% would recommend
    224 recommendations
    4 out of 5 stars
    Thumbs up graphic, would recommend
    21 October, 2026Verified purchase

    (no review title)

    Standard generic for Tylenol, no issues.
    RG
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    8 September, 2026Verified purchase

    Good product

    Cheaper than the name brand and works the same so it’s a great deal!
    Debbie
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    1 out of 5 stars
    Thumbs down graphic, would not recommend
    31 August, 2026

    Terrible

    Awful. Filled with sugar. As soon as it touches your tongue. Who did that
    X
    quality: 1 out of 5
    value: 1 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    28 August, 2026Verified purchase

    It works!

    It's entire body relief for every ache and pain. It'll definitely stop a throbbing headache quick! I keep this on hand! Yes, even for period pain when it's chaotic. It'll make it calm down, but won't completely defeat a bad period unfortunately. Any relief is still relief tho!
    vix
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    15 August, 2026Verified purchase

    Ache reducer

    Take these as needed to help quell joint aches. Seem to last 8-10 hours. Also have the PM version for sleep relief as needed.
    Ross
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    13 August, 2026Verified purchase

    (no review title)

    It works as intended!
    Target Team Member
    Did you find this review helpful?
    1 out of 5 stars
    11 August, 2026Verified purchase

    (no review title)

    Never revived if
    Oohmann55
    Did you find this review helpful?
    4 out of 5 stars
    9 August, 2026Verified purchase

    (no review title)

    Good good
    Did you find this review helpful?
    1 out of 5 stars
    Thumbs down graphic, would not recommend
    25 July, 2026Verified purchase

    (no review title)

    item appeared in stock when ordered but turns out out of stock. Also was charged for item and have to wait for a refund. Do better inventory of products TARGET. Very Unsatisfied.
    Bill
    quality: 1 out of 5
    value: 1 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    24 June, 2026Verified purchase

    (no review title)

    I didn't like my previous Up&Up bottle of acetaminophen because tablets were round and flavored and coated with red. This bottle is back to a good plain caplet.
    Jean
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs down graphic, would not recommend
    24 June, 2026Verified purchase

    (no review title)

    great price great item
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    23 June, 2026Verified purchase

    Just as good as name brand

    great price and quantity
    Sneef
    quality: 5 out of 5
    value: 5 out of 5
    1 guest found this review helpful. Did you?
    4 out of 5 stars
    Thumbs up graphic, would recommend
    11 June, 2026Verified purchase

    (no review title)

    This very affordable compared to other brands. I love that it worked great for my minor headache. And they're easy to swollen with no problem.
    Sheyi
    quality: 5 out of 5
    value: 5 out of 5
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    Thumbs down graphic, would not recommend
    7 June, 2026Verified purchase

    excellent quality

    Loved the quality of this product.
    PeterCannice
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    7 June, 2026Verified purchase

    Great

    This works great, no complaints!
    Malllory
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    8 May, 2026Verified purchase

    Works well

    Same as Tylenol. Works just as well for a much better price.
    Lynnette
    quality: 5 out of 5
    value: 5 out of 5
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    9 April, 2026

    Up & Up Tylenol

    Great
    Vanessa
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    28 March, 2026Verified purchase

    works and good price

    works well
    Harminder
    quality: 4 out of 5
    value: 5 out of 5
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    28 March, 2026

    Headache meds

    Love the target brand
    Sarah D
    Did you find this review helpful?
    1 out of 5 stars
    Thumbs down graphic, would not recommend
    13 March, 2026Verified purchase

    (no review title)

    Unacceptable number of broken pills in bottle.
    Brandy
    quality: 1 out of 5
    value: 1 out of 5
    4 guests found this review helpful. Did you?

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