Acetaminophen Arthritis Pain Relief 650mg Extended Release Caplets - 100ct - up&up™
$6.49
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Guests are saying
This product offers an effective solution for pain relief, particularly for those suffering from arthritis. Guests appreciate the easy-to-open cap design, which is especially beneficial for individuals with hand pain. The extra potency and economical pricing compared to name brands make it a popular choice. Many guests report significant relief from aches and pains, making it a reliable option for daily use.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.8 out of 5 stars with 597 reviews
quality: 4.87 out of 5
value: 4.85 out of 5
100% would recommend
30 recommendations
5 out of 5 stars
Thumbs up graphic, would recommend
29 November, 2025Verified purchase
Easy open bottle, arthritis strength.
This is my go-to acetaminophen, I take it twice a day for arthritis, lupus, and Reynaud’s. I can no longer take NSAIDS. This doesn’t work as well, but the stronger dosage (2) helps take the edge off. I especially love the easy grip top. I have yet to see one like this anywhere else.
5 out of 5 stars
Thumbs up graphic, would recommend
23 November, 2025Verified purchase
(no review title)
Easy open top bottle
5 out of 5 stars
17 August, 2025Verified purchase
Helps Me Sleep Through Knee Pain
Just like brand name Arthritis medication, this works really well for nighttime relief. Helps ease my aching knees, especially on rainy days, so I can actually get a good night’s sleep. Reliable and effective when joint pain is acting up.
5 out of 5 stars
Thumbs up graphic, would recommend
20 June, 2025Verified purchase
Name brand smish smosh
I have been in the market looking for something to help me with my arthritis pain. I have severe rheumatoid arthritis and it comes with severe pain as well. I receive prescribed medications to help me with this, but even they weren’t cutting it. I couldn’t afford any more expensive prescriptions, so I was in search of something affordable and over the counter that could offer me some mild or moderate pain relief. I’ve tried several more pricey name brand options, and other store brand options, to no avail. With that being said… I bought these with little to no expectations. But, dang was I pleasantly surprised 😲. These helped me A LOT. I took two before bed, and it was the first time I slept through the night without waking up tossing and turning from my joint pains. I still recommend talking to your physician before starting any kind of medication regimen. With that out of the way, I highly recommend these. These might be target brand and not the expensive name brand, but I was definitely blow off my feet with how well they worked for me. But everybody is different. Target you are such a goat. Can’t beat the value either.
4 out of 5 stars
Thumbs up graphic, would recommend
20 June, 2025Verified purchase
Acetaminophen 650mg
This helps with my arthritis pain and d the other pain I get from Fibromyalgia it works better than the pain medicine action that I was using before without side effects.
5 out of 5 stars
Thumbs up graphic, would recommend
16 March, 2025Verified purchase
Don't leave home without it
This helps with the arthritis pain in my thumb joints. Also helps with my husband’s back pain.
5 out of 5 stars
Thumbs up graphic, would recommend
27 January, 2024Verified purchase
Great value
Just as effective as the name, brand and less expensive
4 out of 5 stars
Thumbs up graphic, would recommend
19 January, 2024Verified purchase
Online shopper
I have arthritis in my hands, and the cap is very easy to remove, and compared to regular Tylenol brand it's the same and less expensive
5 out of 5 stars
Thumbs up graphic, would recommend
30 December, 2023Verified purchase
Best Cap on a medicine bottle
I know it seems weird to be so impressed with the cap on the bottle. But as a senior with arthritis in my hands, its very difficult to open medicine bottles. When you are in pain the last thing you want to do is have to struggle to open your meds. This cap is a little oversized making it easy to grab and the flower shape makes it easy to turn and open. Would that all mfgs that make meds for seniors used this kind of cap. Such a small thing but what a difference it makes.
5 out of 5 stars
Thumbs up graphic, would recommend
6 November, 2023Verified purchase
Great Buy!
I like the extra potency in this pain killer. I take two and the aches and pains of the day literally go away in no time. It works fast and it works well. The price is much better than the name brand. I’ll keep on buying the Up & Up brand.
5 out of 5 stars
Thumbs up graphic, would recommend
1 November, 2023Verified purchase
Aches and pains go away
Works just as good as name brand!
5 out of 5 stars
Thumbs up graphic, would recommend
26 October, 2023Verified purchase
Wonderful
Works great for chronic pain. Lasts awhile. Just as good as name brand and way less expensive!
5 out of 5 stars
Thumbs up graphic, would recommend
29 January, 2023Verified purchase
Great for arthritic hip
Very comparable to name brand in relieving arthritic pain and less expensive.
5 out of 5 stars
Thumbs up graphic, would recommend
19 January, 2023Verified purchase
Arthritis Pain Relief
Product works great for Arthritis pain
5 out of 5 stars
Thumbs up graphic, would recommend
12 January, 2023
great product
works great. my hand does not hurt anymore.
5 out of 5 stars
Thumbs up graphic, would recommend
19 December, 2022Verified purchase
Arth pain reliever
Works well and economical
5 out of 5 stars
Thumbs up graphic, would recommend
17 November, 2022Verified purchase
Pain reliever
This arthritis strength acetaphetamine is excellent for pain
5 out of 5 stars
Thumbs up graphic, would recommend
19 October, 2022Verified purchase
Review of Generic Arthritis Tylenol
It’s a good product for the value.
5 out of 5 stars
Thumbs up graphic, would recommend
29 August, 2022Verified purchase
Great pain reliever
Helps keep my joint pain at bay for the entire day.
5 out of 5 stars
Thumbs up graphic, would recommend
27 March, 2022Verified purchase
WORKS ON pain
Works Just As Well As the Name Bra D