New ArrivalsHalloweenChristmasGift IdeasClothing, Shoes & AccessoriesHomeFurnitureElectronicsToysVideo GamesGroceryHousehold EssentialsBeautyBabyKitchen & DiningSchool & Office SuppliesMovies, Music & BooksCharacter ShopSports & OutdoorsBackpacks & LuggagePersonal CareHealthPetsUlta Beauty at TargetTarget OpticalParty SuppliesGift CardsBullseye’s PlaygroundDealsClearanceTarget New Arrivals Target Finds #TargetStyleCelebrate DiwaliDía de MuertosStore EventsAsian-Owned Brands at TargetBlack Beyond MeasureMás QueWomen-Owned Brands at TargetLGBTQIA+ ShopTop DealsTarget Circle DealsWeekly AdShop Order PickupShop Same Day DeliveryRegistryRedCardTarget CircleFind Stores
Day & Night Maximum Strength Sinus Relief Caplets - 20ct - up&up™ - 2 of 4Day & Night Maximum Strength Sinus Relief Caplets - 20ct - up&up™ - 3 of 4Day & Night Maximum Strength Sinus Relief Caplets - 20ct - up&up™ - 4 of 4
Day & Night Maximum Strength Sinus Relief Caplets - 20ct - up&up™ - 1 of 4

Day & Night Maximum Strength Sinus Relief Caplets - 20ct - up&up™

$7.39

In Stock

Eligible for registries and wish lists

At a glance

Sponsored

About this item

Highlights

  • Packaging may vary. Same trusted quality
  • Multi-symptom cold medicine helps lessen congestion, coughs and aches
  • Day and night cold medicine helps you through all 24 hours
  • 20 total caplets help provide easy-to-take relief
  • Maximum strength formula is targeted even toward tough symptoms

Description

Tough colds need 24-hour relief, and you can find it with the Day and Night Maximum Strength Sinus Relief Caplets 20 Count from up&up™. These multi-symptom cold medicine caplets come in a day formulation and a night formulation tailored to treat your cold symptoms no matter the hour. Both formulations have active ingredients that help to ease aches and pains, lessen sinus congestion and make coughs more productive. Whether you need to get through daytime activities or get a good night's sleep, don't let a cold stop you — make sure you have the right medicine on hand.

We believe making smart choices for the people, places, and pets in your life should be easy and affordable. And, having quality you can trust should be a given. That’s why you can count on our promise – caring for your everyday in every way.

Satisfaction guaranteed – Love it or your money back.
Suggested Age: 12 Years and Up
Active Ingredient Strength Value: 325 milligrams
Product Warning: Do not use with other diphenhydramine products, consult a doctor if you have urination issues, consult a doctor if you have a breathing problem, consult a doctor if you are pregnant or nursing, consult a doctor if you have high blood pressure, consult a doctor if you have thyroid disease, consult a doctor if you have diabetes, do not use if you are taking an MAOI, Contains Acetaminophen, not for children under the age of 12, consult a doctor if taking prescription drugs, consult a doctor if you have liver disease
Product Form: Caplet
Primary Active Ingredient: Acetaminophen
Package Quantity: 20
Net weight: .07 Pounds
Features: Daytime and Nighttime Use
TCIN: 51584844
UPC: 311673530023
Item Number (DPCI): 094-03-0452
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Active ingredients

acetaminophen 325.0mg guaifenesin 200.0mg phenylephrine hcl 5.0mg diphenhydramine hcl 12.5mg

Purpose

Pain reliever Expectorant Nasal decognestant Antihistamine/cough suppressant

Uses

temporarily relieves: nasal congestion headache minor aches and pains sinus congestion and pressure cough (Nighttime only) runny nose and sneezing (Nighttime only) temporarily promotes nasal and/or sinus drainage helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive (Daytime only)

Directions

Directions do not use more than directed do not take more than 12 caplets in any 24-hour period adults and children 12 years and over: take 2 caplets every 4 hours children under 12 years: do not use

Other information

Other information TAMPER EVIDENT: DO NOT USE IF OUTER PACKAGE IS OPENED OR BLISTER IS TORN OR BROKEN store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F) see end flap for expiration date and lot number

Inactive ingredients

(daytime only) corn starch, crospovidone, fd&c red #40 aluminum lake, fd&c yellow #6 aluminum lake, magnesium stearate, maltodextrin, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, silicon dioxide, sodium starch glycolate, stearic acid, talc, titanium dioxide (nighttime only) corn starch, croscarmellose sodium, crospovidone, fd&c blue #1 aluminum lake, fd&c blue #2 aluminum lake, iron oxide yellow, magnesium stearate, methacrylic acid and ethyl acrylate copolymer, microcrystalliine cellulose, polyethylene glycol, polyvinyl alcohol, povidone, silicon dioxide, sodium bicarbonate, stearic acid, talc, titanium dioxide

Shipping details

Estimated ship dimensions: 0.94 inches length x 2.9 inches width x 4.55 inches height
Estimated ship weight: 0.07 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 365 days of the date it was purchased in store, shipped, delivered by a Shipt shopper, or made ready for pickup.
See the return policy for complete information.

Q: Can children under 12 use this product?

submitted by AI Shopping Assistant - 10 days ago
  • A: No, this product is not recommended for children under the age of 12.

    submitted byAI Shopping Assistant - 10 days ago
    Ai generated

Q: How many caplets are included in the package?

submitted by AI Shopping Assistant - 10 days ago
  • A: The package includes a total of 20 caplets for day and night use.

    submitted byAI Shopping Assistant - 10 days ago
    Ai generated

Q: What symptoms does this medicine target?

submitted by AI Shopping Assistant - 10 days ago
  • A: The medicine targets congestion, coughs, aches, and sinus issues for both day and night.

    submitted byAI Shopping Assistant - 10 days ago
    Ai generated

Q: What is the primary active ingredient in the caplets?

submitted by AI Shopping Assistant - 10 days ago
  • A: The primary active ingredient in the caplets is Acetaminophen.

    submitted byAI Shopping Assistant - 10 days ago
    Ai generated

Q: What is the active ingredient strength per caplet?

submitted by AI Shopping Assistant - 10 days ago
  • A: Each caplet contains 325 milligrams of the active ingredient.

    submitted byAI Shopping Assistant - 10 days ago
    Ai generated

Related Categories

Guests are saying

This product is highly regarded for its effectiveness in providing sinus relief without causing jitteriness or insomnia, making it a preferred choice for allergy sufferers. Guests appreciate its ability to help with congestion and headaches, and many find it comparable to name-brand medications. However, some guests express concerns about the lack of clear dosing instructions and the uneven distribution of day and night caplets. Overall, it offers a good value for those seeking relief from sinus issues.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.5 out of 5 stars with 475 reviews
    effectiveness: 4.07 out of 5
    quality: 4.07 out of 5
    value: 4.21 out of 5
    76% would recommend
    26 recommendations
    4 out of 5 stars
    Thumbs up graphic, would recommend
    2 October, 2025Verified purchase

    Alternative to name brand Sinus medicine

    what I like about this combo is that it's very affordable and that you can use per daytime as well as night time. the daytime sinus medicine work extremely well. I did not have any sinus headaches or even congestion throughout the day. I normally take this with a hot liquid such as tea or coffee to clear the sinuses however, the night time sinus medicine took extremely long time for it to work well on the sinuses. so if you wanting something affordable instead of the name brand sinus medicine this would work. I was actually looking for the liquid capsules because they often work better than the pill form.
    Naturally Ree
    effectiveness: 3 out of 5
    quality: 4 out of 5
    value: 4 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    10 April, 2025

    No sniffles all day

    Good stuff. Night time took a while to kick in. But daytime worked incredibly well. Did not sniffle all day.
    Trisueh
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    11 March, 2025

    Highly recommended

    The best sinus relief meds that work and are affordable. I got this after having a sinus infection 2 months ago. A client recommended I try this as she said she uses it for her sinus infections. It provided some relief and helped me feel better.
    Sara
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    27 January, 2025Verified purchase

    Great value for great product

    Just as good as name brand at a heck of a price. Love the day / night mix, good value for a couple days medication to get you feeling alright.
    Matt
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    27 October, 2024

    Yes please

    This is the only thing that helps my allergies.
    LK
    effectiveness: 5 out of 5
    value: 5 out of 5
    quality: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    6 October, 2024Verified purchase

    Decongestants make me jittery

    Most sinus relief products make me feel jittery, increases my heart rate and gives me insomnia. So far this is the only one I have found that doesn’t do this to me and I get relief in my sinuses.
    Jenni
    value: 5 out of 5
    effectiveness: 5 out of 5
    quality: 5 out of 5
    Did you find this review helpful?
    4 out of 5 stars
    Thumbs up graphic, would recommend
    2 October, 2024Verified purchase

    Sinus relief day/night

    While the taste of the caplets are a little off-putting, I couldn't really tell what they smelt like because I was so congested so they did help a lot with that. They helped me sleep which was good. I know a lot of people keep saying that that they come with no directions but they actually do in the right hand corner. All you have to deal is peel it up and on the back of that tells you the directions so not an issue for me. I liked them and they helped me out a lot. I do wish there were equal amount of night time and I've never understood why day night caplets always have more day than night but either way it helped a lot!
    SJ
    Did you find this review helpful?
    1 out of 5 stars
    Thumbs down graphic, would not recommend
    4 May, 2024

    No directions

    Doesn’t work and worst of all no directions. For that important information I would not recommend.
    Violet
    effectiveness: 1 out of 5
    quality: 1 out of 5
    value: 1 out of 5
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    10 April, 2024Verified purchase

    Works great

    Works just as well as name brand medication. Don’t waste your money and buy this. Caplet size is fine. Can easily swallow. Works within 30 minutes.
    Merissa
    quality: 5 out of 5
    value: 5 out of 5
    effectiveness: 5 out of 5
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    2 March, 2024Verified purchase

    Just like the name brand

    Wish they came with more night time medicine
    Bellamcd
    effectiveness: 5 out of 5
    value: 4 out of 5
    quality: 5 out of 5
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    31 December, 2023Verified purchase

    Good Alternative

    I think these work as well but are way cheaper than the name brand.
    Her Mama
    quality: 5 out of 5
    effectiveness: 5 out of 5
    value: 5 out of 5
    1 guest found this review helpful. Did you?
    1 out of 5 stars
    Thumbs down graphic, would not recommend
    30 December, 2023

    Will not buy again

    Not effective at clearing congestion
    TargetLove
    value: 1 out of 5
    quality: 1 out of 5
    effectiveness: 1 out of 5
    Did you find this review helpful?
    2 out of 5 stars
    Thumbs down graphic, would not recommend
    7 July, 2023Verified purchase

    Explore Options

    Thought it was just me until I looked at the reviews. The pills have a strange odor to them, caused me to burp up a foul taste. Stomach didn’t feel the greatest either. Stopped them and a day later I have never been so happy to have a sinus infection, the other side effects are gone. Also for the life of me I did not see any instructions, I prolly took too many 😂
    Wantssumbud
    effectiveness: 3 out of 5
    quality: 1 out of 5
    value: 5 out of 5
    2 guests found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    28 April, 2023

    Who needs the name brand when Target makes this?!

    Literally got my mom through Covid. We tried other drugstore brands when we ran out and her breathing got so bad. Bought more of this the next morning! Thanks Target for making reliable and affordable knock offs!! ⚡️
    Julia Gulia
    quality: 5 out of 5
    effectiveness: 5 out of 5
    value: 5 out of 5
    2 guests found this review helpful. Did you?
    2 out of 5 stars
    Thumbs down graphic, would not recommend
    30 March, 2023

    No instructions?

    As others have pointed out theres no instructions included? How are we supposed to know how many to take ? it only says the amount not to surpass per day.. so Im assuming 2 pills per day and night at this point... lets see if it works!
    Elle
    effectiveness: 2 out of 5
    quality: 2 out of 5
    value: 2 out of 5
    13 guests found this review helpful. Did you?
    4 out of 5 stars
    3 January, 2023

    Odd smell/taste but it works

    The smell of the pills remind me of those dog beggin strips. If you can get past that, they work well for clogged sinuses.
    GME
    quality: 4 out of 5
    value: 5 out of 5
    effectiveness: 5 out of 5
    1 guest found this review helpful. Did you?
    4 out of 5 stars
    1 January, 2023

    The reviews are right

    They do smell like beef jerky it’s actually kind of gross
    Gb
    value: 4 out of 5
    effectiveness: 4 out of 5
    quality: 4 out of 5
    2 guests found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    11 November, 2022Verified purchase

    Works!!

    Provided both day & night time relief!!
    JJ
    value: 5 out of 5
    effectiveness: 5 out of 5
    quality: 5 out of 5
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    29 October, 2022Verified purchase

    Strong and good

    Sinus infection lifesaver!! Helps with headache, sneezing, and mucus
    JeremyK
    quality: 5 out of 5
    effectiveness: 5 out of 5
    value: 5 out of 5
    1 guest found this review helpful. Did you?
    4 out of 5 stars
    Thumbs up graphic, would recommend
    9 October, 2022

    Beef Jerky Scented!

    You get about 2-3 days and 4 nights of doses. They work, just... are kind of uneven. Also huge pills that... smell like beef jerky for some reason?!
    Anon Reviewer
    quality: 5 out of 5
    value: 4 out of 5
    effectiveness: 5 out of 5
    4 guests found this review helpful. Did you?

    Get top deals, latest trends, and more.

    Privacy policy

    Footer

    About Us

    About TargetCareersNews & BlogTarget BrandsBullseye ShopSustainability & GovernancePress CenterAdvertise with UsInvestorsAffiliates & PartnersSuppliersTargetPlus

    Help

    Target HelpReturnsTrack OrdersRecallsContact UsFeedbackAccessibilitySecurity & FraudTeam Member ServicesLegal & Privacy

    Stores

    Find a StoreClinicPharmacyTarget OpticalMore In-Store Services

    Services

    Target Circle™Target Circle™ CardTarget Circle 360™Target AppRegistrySame Day DeliveryOrder PickupDrive UpFree 2-Day ShippingShipping & DeliveryMore Services
    PinterestFacebookInstagramXYoutubeTiktokTermsCA Supply ChainPrivacy PolicyCA Privacy RightsYour Privacy ChoicesInterest Based AdsHealth Privacy Policy