Compare to the active ingredient in Mucinex, Guaifenesin 600 mg
Get relief that lasts up to 12 hours
Thins and loosens mucus to make coughs more productive
Relieves chest congestion, gluten free
For adults and children 12 years of age and older
Description
Compare to Mucinex active ingredient. Say goodbye to mucus and chest congestion with Up&Up Cough and Mucus Relief Extended-Release Tablets, Guaifenesin 600 mg. Just one dose releases the medicine you need immediately and lasts for up to 12 hours to help loosen phlegm (mucus) and thin bronchial secretions in the airways to make wet coughs more productive. This expectorant relieves chest congestion and mucus for up to 12 hours so you have quick and long-lasting cough relief. Clear bothersome excess mucus and avoid frequent doses of cold medicine. For adults and children 12 years of age and older. Gluten free.
We believe making smart choices for the people, places, and pets in your life should be easy and affordable. And, having quality you can trust should be a given. That’s why you can count on our promise – caring for your everyday in every way.
Satisfaction guaranteed – Love it or your money back.
Suggested Age: 12 Years and Up
Health Facts: Gluten-Free
Active Ingredient Strength Value: 600 Milligrams
Product Warning: Consult a doctor if you are pregnant or nursing, not for children under the age of 12, keep out of reach of children
Product Form: Tablet
Primary Active Ingredient: Guaifenesin
Package Quantity: 20
Features: Daytime and Nighttime Use
TCIN: 75558014
UPC: 370030118120
Item Number (DPCI): 094-03-0072
Origin: Made in the USA or Imported
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.
Active ingredients
guaifenesin' '600.0mg
Purpose
Expectorant
Uses
Uses
helps loosen phlegm (mucus) and thin
bronchial secretions to rid the bronchial
passageways of bothersome mucus and make
coughs more productive
Directions
Directions
do not crush, chew, or break tablet,
take with a full glass of water,
this product can be administered without
regard for timing of meals,
adults and children 12 years of age and over:
1 or 2 tablets every 12 hours. Do not exceed
4 tablets in 24 hours,
children under 12 years of age: do not use
Other information
Other information
store at 20-25℃ (68-77°F)
Inactive ingredients
carbomer homopolymer type b, fd&c blue #1 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, sodium starch glycolate
Shipping details
Estimated ship dimensions: 0.94 inches length x 3.51 inches width x 5.33 inches height
Estimated ship weight: 0.07 pounds
Return details
This item can be returned to any Target store or Target.com.
This item must be returned within 365 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
Q: The up&up brand is often gluten free (thank you so much) - can you please confirm whether this particular item is gluten free? I don't see any print stating so on the box in the photos.
submitted by JJN - 6 months ago
A: Thank you for contacting us. To provide answers to ingredient questions we require the lot number from the product you have purchased. Please contact us at 1-800-719-9260 and reference case # 2138185 and we can look this information up for you. We look forward to speaking with you.
This product has garnered mixed feedback from guests, with many praising its effectiveness in relieving congestion and sinus pressure at a lower price compared to name brands. However, concerns have been raised about changes in ingredients and packaging, particularly the introduction of blue tablets and difficulty in accessing pills from blister packs. Despite these issues, guests appreciate the value and effectiveness of the product for managing symptoms during cold and allergy seasons.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.6
4.6 out of 5 stars
564 star ratings
4.6 out of 5 stars with 564 reviews
effectiveness
4.2 out of 5
effectiveness: 4.21 out of 5
quality
4.0 out of 5
quality: 3.95 out of 5
value
4.1 out of 5
value: 4.14 out of 5
68% would recommend
41 recommendations
1 out of 5 stars
Thumbs down graphic, would not recommendWould not recommend
30 August, 2026
Pills are blue now. False advertising.
Pills are blue!! Extra crap for the people with no warning on your Your site.
Rachel
effectiveness
1.0 out of 5
effectiveness: 1 out of 5
quality
1.0 out of 5
quality: 1 out of 5
value
3.0 out of 5
value: 3 out of 5
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommendWould not recommend
15 May, 2026Verified purchase
Target you can and should do better.
poor delivery this is the condition of boxes when I opened the plastic mailer they were sent in. The pills inside seem to be okay, but its a wonder!
Teresa
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommendWould not recommend
17 March, 2026Verified purchase
pills are blue
ingredients are now different. pills are BLUE
1 reply from the Product Manufacturer team - 6 months ago
We are sorry to hear about your experience with the Mucus Relief Extended Release Tablets - 20ct - up&up. We take customer service concerns very seriously and are committed to providing our customers with high quality products. We strongly encourage you to contact our Contact Center Team at 800-719-9260 or via email by going to www.perrigo.com/contact-us and reference case number 2142351. We look forward to addressing your concerns and hearing from you!
Emily
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommendWould not recommend
15 March, 2026Verified purchase
Now has added coloring!
I have purchased this product in the past and it worked well. I mainly picked this one because it didn’t have added coloring. The recent box I purchased now has FD&C Blue #1 Aluminum Lake. Really frustrating because the listed product in the site still shows a white pill and the old ingredients list. If you are going to change the product, at least make sure the correct ingredients are listed so customers can decide to go with a different product if they are unable to consume added coloring. Very frustrating.
1 reply from the Product Manufacturer team - 6 months ago
We are sorry to hear about your experience with the Up & Up Mucus Relief Extended Release Tablets product. We take customer service concerns very seriously and are committed to providing our customers with high quality products. We strongly encourage you to contact our Contact Center Team at 1-800-719-9260 or via email by going to www.perrigo.com/contact-us and reference case number 2141179. We look forward to addressing your concerns and hearing from you!
Mamaof2
effectiveness
1.0 out of 5
effectiveness: 1 out of 5
quality
1.0 out of 5
quality: 1 out of 5
value
1.0 out of 5
value: 1 out of 5
1 guest found this review helpful. Did you?
1 out of 5 stars
30 December, 2025
False representation in product listing - contains dye
I selected this specific product when placing an order because the item listing on the Target app showed photos of white tablets and a box where the ingredients list did not contain any dye. However, the product I received is blue tablets and the box lists an inactive ingredient of FD&C blue #1 aluminum lake.
1 reply from the Product Manufacturer team - 8 months ago
We are sorry to hear about your experience with the Up & Up Mucus Relief. As the manufacturer, we cannot control the product listing on Target's site but understand your concerns with the ingredients. We take customer service concerns very seriously and are committed to providing our customers with high quality products. We strongly encourage you to contact us at 1-800-719-9260 or email by going to www.perrigo.com/contact-us and reference case number 2116193. We look forward to addressing your concerns and hearing from you!
Anonymous
3 guests found this review helpful. Did you?
1 out of 5 stars
17 December, 2025Verified purchase
(no review title)
Tried them out three times while I’ve been sick hasn’t done anything for my congestion at all
1 reply from the Product Manufacturer team - 9 months ago
We are sorry to hear about your experience with the Up & Up Mucus Relief. We take customer service concerns very seriously and are committed to providing our customers with high quality products. We strongly encourage you to contact us at 1-800-719-9260 or email by going to www.perrigo.com/contact-us and reference case number 2113218. We look forward to addressing your concerns and hearing from you!
Nicole
effectiveness
1.0 out of 5
effectiveness: 1 out of 5
Did you find this review helpful?
1 out of 5 stars
21 November, 2025Verified purchase
Added blue coloring
I used to like this stuff. Just got a new box and the white pills now have Blue lake aluminum #1 for no reason. I bought them before because they didn’t have the added chemical and now they do. So disappointing. I am returning.
1 reply from the Product Manufacturer team - 9 months ago
We are sorry to hear about your experience with the Up & Up Mucus Relief Tablets. We take customer service concerns very seriously and are committed to providing our customers with high quality products. We strongly encourage you to contact us at 1-800-719-9260 or email by going to www.perrigo.com/contact-us and reference case number 2105015. We look forward to addressing your concerns and hearing from you!
Jsargent
2 guests found this review helpful. Did you?
1 out of 5 stars
Thumbs down graphic, would not recommendWould not recommend
2 November, 2025Verified purchase
Blister Packaging is a Problem.
The product is good, but the packaging is a problem. I cannot get the pills out of the blister packs, so I had to throw them away and get the brand-name Mucinex. Very disappointed as the Up&Up brand is less expensive.
1 reply from the Product Manufacturer team - 10 months ago
We are sorry to hear about your experience with the packaging of the Up & Up Mucus Relief. We take customer service concerns very seriously and are committed to providing our customers with high quality products. We strongly encourage you to contact us at 1-800-719-9260 or email by going to www.perrigo.com/contact-us and reference case number 2098265. We look forward to addressing your concerns and hearing from you!
Rug pad was not delivered
effectiveness
5.0 out of 5
effectiveness: 5 out of 5
quality
5.0 out of 5
quality: 5 out of 5
value
2.0 out of 5
value: 2 out of 5
Did you find this review helpful?
5 out of 5 stars
Thumbs up graphic, would recommendWould recommend
26 March, 2025Verified purchase
Medicine cabinet staple!
Great value and effective!
JNM5
effectiveness
5.0 out of 5
effectiveness: 5 out of 5
quality
5.0 out of 5
quality: 5 out of 5
value
5.0 out of 5
value: 5 out of 5
3 guests found this review helpful. Did you?
4 out of 5 stars
Thumbs up graphic, would recommendWould recommend
3 March, 2025Verified purchase
Cant live without!
these help congestion and sinus headaches.
SamKo
effectiveness
5.0 out of 5
effectiveness: 5 out of 5
quality
5.0 out of 5
quality: 5 out of 5
value
3.0 out of 5
value: 3 out of 5
4 guests found this review helpful. Did you?
1 out of 5 stars
Thumbs down graphic, would not recommendWould not recommend
3 February, 2025Verified purchase
Doesn’t. Explain. Ineffectiveness.
Poor quality product. Not effective.
All Men
effectiveness
1.0 out of 5
effectiveness: 1 out of 5
quality
1.0 out of 5
quality: 1 out of 5
value
1.0 out of 5
value: 1 out of 5
Did you find this review helpful?
3 out of 5 stars
Thumbs down graphic, would not recommendWould not recommend
13 January, 2025
Try vicks sinex spray instead
It didn't clear up my congestion completely, but also didn't give me any weird side effects like the extra strength does. I will use up the rest important my next flu/cold but I won't be purchasing again. Vicks sinex spray did the job for me.
Jess8780
effectiveness
3.0 out of 5
effectiveness: 3 out of 5
quality
3.0 out of 5
quality: 3 out of 5
value
4.0 out of 5
value: 4 out of 5
1 guest found this review helpful. Did you?
1 out of 5 stars
Thumbs down graphic, would not recommendWould not recommend
31 October, 2024Verified purchase
Concerning inactive ingredient
I believe this contains the carcinogen “carbomer”, so we threw ours out. See https://www.npr.org/2024/08/16/nx-s1-5077764/millions-of-americans-may-be-getting-cancer-causing-chemical-in-generic-cold-medicine.
LastChild40
effectiveness
5.0 out of 5
effectiveness: 5 out of 5
quality
1.0 out of 5
quality: 1 out of 5
value
1.0 out of 5
value: 1 out of 5
15 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommendWould recommend
11 October, 2024
Works great
Great generic brand compared to name brand.
Satisfied costomer
quality
5.0 out of 5
quality: 5 out of 5
value
5.0 out of 5
value: 5 out of 5
effectiveness
5.0 out of 5
effectiveness: 5 out of 5
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommendWould not recommend
10 October, 2024Verified purchase
Difficult bubble srap
I have been getting this product for years. My original review concerned the wasteful product container. I could get (easily) two bottles into one. Now my issue is the bubble wrap of the pills, I am almost 70 years old and this product is very difficult to push through! I am considering a different product that is more user friendly😔😔
Dian
quality
1.0 out of 5
quality: 1 out of 5
value
5.0 out of 5
value: 5 out of 5
effectiveness
5.0 out of 5
effectiveness: 5 out of 5
Did you find this review helpful?
1 out of 5 stars
Thumbs down graphic, would not recommendWould not recommend
30 September, 2024Verified purchase
New box but does not work
New formulation doesn’t work! The pills that came in the bottle were great, as all of these reviews state, prior to September 2024. Now, same brand, same generic, same price, but in a blister pack with a different color pill. Doesn’t work at all. Please bring back the prior pills in a bottle.
Bring back prior version
effectiveness
1.0 out of 5
effectiveness: 1 out of 5
quality
1.0 out of 5
quality: 1 out of 5
value
5.0 out of 5
value: 5 out of 5
5 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommendWould recommend
5 August, 2024Verified purchase
Very good for sticky sinuses
These work well but drink the recommended water.
DD
1 guest found this review helpful. Did you?
1 out of 5 stars
Thumbs down graphic, would not recommendWould not recommend
26 July, 2024Verified purchase
Mucus relief
This item did not relieve any pressure or release the mucus buildup.
Pp
quality
1.0 out of 5
quality: 1 out of 5
value
1.0 out of 5
value: 1 out of 5
effectiveness
1.0 out of 5
effectiveness: 1 out of 5
Did you find this review helpful?
4 out of 5 stars
Thumbs up graphic, would recommendWould recommend
5 June, 2024Verified purchase
Good generic alternative
Don't buy the name brand stuff if you don't have to. This is the same! This recently helped me knock out a case of sinusitits before it required antibiotics. I always buy this one or the one with the cough suppressant as well. If you are prone to sinus infections and your doctor recommends the name brand use this instead. The only downside is it tastes awful when you swallow it and the pill is pretty large.
CF
effectiveness
5.0 out of 5
effectiveness: 5 out of 5
quality
5.0 out of 5
quality: 5 out of 5
value
4.0 out of 5
value: 4 out of 5
3 guests found this review helpful. Did you?
5 out of 5 stars
Thumbs up graphic, would recommendWould recommend
9 April, 2024Verified purchase
Helped me a lot
I couldn’t get phlegm out of my throat for weeks until I started taking this daily. Helped me a lot!
