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Timeless Skin Care Matrixyl Synthe'6 Serum - 2 of 4Timeless Skin Care Matrixyl Synthe'6 Serum - 3 of 4Timeless Skin Care Matrixyl Synthe'6 Serum - 4 of 4
Timeless Skin Care Matrixyl Synthe'6 Serum - 1 of 4

Timeless Skin Care Matrixyl Synthe'6 Serum - 1 fl oz: Hydrating, Wrinkle & Fine Line Reduction, for Mature & Dry Skin


Size1 fl oz

In Stock

Eligible for registries and wish lists
Available deals

Target Circle Deal: Buy 1, get 1 25% off select skincare products

Eligible with Target Circle membership ∙ Expires Mar 14 ∙ Details

At a glance

About this item

Highlights

  • Restores firmness to the skin
  • Stimulates collagen & elastin production
  • Increases skin elasticity
  • Diminishes pronounced fine lines & wrinkles
  • Promotes optimal skin hydration levels
  • Paraben & Sulfate Free
  • Fragrance and Dye Free
  • Made in the USA
  • Cruelty Free - Leaping Bunny Certified
  • More actives, less chemicals

Description

The Restorer - Help turn back time on the visible signs of aging with Matrixyl®️ synthe’6®️. With six critical skin-building essentials, this powerful polypeptide targets pronounced wrinkles and expression lines by stimulating collagen production. Along with the ultra-hydrating properties of Hyaluronic Acid, it helps tired, damaged skin, and treats pronounced wrinkles and sun damaged skin. Lifts and plumps to reveal firmer, younger-looking skin. Beneficial for skin on the neck and décolleté.

How it works: Timeless Skin Care's Matrixyl S6 contains a 2% concentration of Matrixyl®️ Synthe’6®️, a powerful polypeptide that promotes collagen production. This polypeptide stimulates six major constituents of the skin matrix and dermal-epidermal junction (collagen I, II, IV, fibronectin, hyaluronic acid, and lamin 5). Combined with Hyaluronic Acid for powerful hydration, this serum helps reverse the visible signs of aging and smooths out deep wrinkles and fine lines.

Recommended for: All skin types, especially dry and mature skin

Targets: Visible signs of aging, Wrinkles

Application: Use 2-3 drops onto clean skin and smooth with your fingertips. Wait until the product has fully absorbed into the skin before the next step in your routine.

Frequency: Use daily, PM use recommended for best results as skin cells are in a restorative mode while asleep.

Scent: Unscented
Health Facts: Contains Hyaluronic Acid
Product Form: Serum
Sustainability Claims: Not Tested on Animals
Beauty Purpose: Fine Line Reduction, Wrinkle Reduction, Damage Repair, Firming, Hydrating
Recommended Skin Type: Mature, Dry
Net weight: 1 fl oz (US)
TCIN: 80184081
UPC: 858588004787
Item Number (DPCI): 037-12-7340
Origin: Made in the USA
Healthcare Disclaimer:
Content on this site is for reference purposes only. Target does not represent or warrant that the nutrition, ingredient, allergen and other product information on our Web or Mobile sites are accurate or complete, since this information comes from the product manufacturers. On occasion, manufacturers may improve or change their product formulas and update their labels. We recommend that you do not rely solely on the information presented on our Web or Mobile sites and that you review the product's label or contact the manufacturer directly if you have specific product concerns or questions. If you have specific healthcare concerns or questions about the products displayed, please contact your licensed healthcare professional for advice or answers.
If the item details aren’t accurate or complete, we want to know about it.

Ingredients:

water, matrixyl synthe'6, aloe, glycerin, hyaluronic acid, benzylalcohol dha.

Shipping details

Estimated ship dimensions: 4.3 inches length x 1.9 inches width x 1.8 inches height
Estimated ship weight: 0.166 pounds

Return details

This item can be returned to any Target store or Target.com.
This item must be returned within 90 days of the date it was purchased in store, delivered to the guest, delivered by a Shipt shopper, or picked up by the guest.
See the return policy for complete information.

Q: Is this product tested on animals?

submitted by AI Shopping Assistant - 22 days ago
  • A: No, this serum has not been tested on animals, following cruelty-free practices.

    submitted byAI Shopping Assistant - 22 days ago
    Ai generated

Q: What key ingredient is included in this serum?

submitted by AI Shopping Assistant - 22 days ago
  • A: The serum contains hyaluronic acid, known for its hydrating properties.

    submitted byAI Shopping Assistant - 22 days ago
    Ai generated

Q: What are the main benefits of using this serum?

submitted by AI Shopping Assistant - 22 days ago
  • A: This serum helps reduce wrinkles, fine lines, and enhances skin firmness while providing hydration.

    submitted byAI Shopping Assistant - 22 days ago
    Ai generated

Q: What skin types is this serum recommended for?

submitted by AI Shopping Assistant - 22 days ago
  • A: It is recommended for mature and dry skin types.

    submitted byAI Shopping Assistant - 22 days ago
    Ai generated

Q: Does this serum have any scent?

submitted by AI Shopping Assistant - 22 days ago
  • A: The serum is unscented, making it suitable for sensitive skin.

    submitted byAI Shopping Assistant - 22 days ago
    Ai generated

Q: Can you use this if you are using Retina?

submitted by Lori - 4 months ago
  • A: Hi there! You certainly can choose to follow the application of the Matrixyl Synthe' 6 Serum with the preferred gel or cream Retin-A in the PM routine to enhance skin-boosting benefits. We encourage you to reach out to support@timelessha.com if you have any further questions!

    submitted byTimeless Skin Care Expert - 4 months ago
    Brand expert

Q: Can I use this with my retinol serum and also what is the layering technique to be used for this serum..?

submitted by Niru - 1 year ago

Q: Can I use it under eyes?

submitted by Sarahlee - 1 year ago
  • A: Hi there! This serum is not formulated for the delicate eye area and therefore it is best to avoid use near the eyes to prevent potential irritation. For more product usage inquiries, we encourage you to email consult@timelessha.com.

    submitted byTimeless Skin Care Expert - 1 year ago
    Brand expert

Q: What is the amount/percentage of Matrixyl Synthe'6 in your formulation?

submitted by Kendra - 2 years ago
  • A: There is a 2% concentration of the Matrixyl Synthe'6 ingredient in our Matrixyl Synthe'6 Serum. Should you have any other specific product questions, we encourage you to reach out to consult@timelessha.com!

    submitted byTimeless Skin Care Expert - 2 years ago
    Brand expert

Q: is Matrixyl 6 safe to use during pregnancy?

submitted by Dre - 3 years ago
  • A: Our products are deemed safe for pregnant and lactating moms. We encourage you to reach out to your doctor for any specific concerns.

    submitted byTimeless Skin Care Expert - 3 years ago
    Brand expert

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Guests are saying

This product has garnered positive feedback for its hydrating and anti-aging properties, making it a staple in many guests' skincare routines. Users appreciate its lightweight texture, quick absorption, and noticeable improvements in skin texture and appearance. Many guests have reported significant reductions in fine lines and wrinkles, making it a favorite among those seeking effective skincare solutions. Its compatibility with other products enhances its effectiveness, contributing to a youthful glow.
    Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
    4.6 out of 5 stars with 70 reviews
    effectiveness: 4.41 out of 5
    quality: 4.88 out of 5
    value: 4.81 out of 5
    86% would recommend
    15 recommendations
    5 out of 5 stars
    5 February, 2026Verified purchase

    (no review title)

    I have only been using this new serum for a week, and I have noticed an improvement in my wrinkles.
    Terri
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    1 December, 2025Verified purchase

    adds a "snap" to skin

    Adds a subtle snap to skin. In the winter or dry climates, be sure to apply to damp skin ad then seal with an occlusive moisturizer since it has hyaluronic acid, which can dry out your skin when the humidity is low.
    Cooper
    Did you find this review helpful?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    29 November, 2025Verified purchase

    Love this as a staple in skin care

    Great product recommended by Hot and Flashy on you tube! It does its job!
    CHowe
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    23 September, 2025Verified purchase

    Great skincare product!

    The timeless skin care line is an amazing, high quality, line of products that provides great results and makes my skin feel amazing. I use this in conjunction with the Vitamin C+E Ferulic Acid Cerum and the Q10 Serum. Incredibly happy with the results. A very simple, non-fussy routine.
    VTSandidge
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    3 guests found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    21 September, 2025Verified purchase

    The best.

    Perfect hydration, I put this on after toner and I just got a professional facial — she said I had some of the best skin she’d ever seen! Highly recommend. A bottle will last you ~3 months at least.
    sydney8385
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    3 guests found this review helpful. Did you?
    5 out of 5 stars
    20 September, 2025
    originally posted on https://www.timelessha.com/
    Image

    Love it

    Fantastic. Use it since 10 years.
    Undisclosed
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    17 September, 2025
    originally posted on https://www.timelessha.com/
    Image

    Love it

    Price and quality are unbeatable - my new holy grail!
    Undisclosed
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    1 June, 2025
    originally posted on https://www.timelessha.com/
    Image

    Great new addition

    Added this product 3 months ago and notice the biggest difference in my neck. Fine lines are disappearing and my neck is looking younger!
    Undisclosed
    Did you find this review helpful?
    4 out of 5 stars
    Thumbs up graphic, would recommend
    21 February, 2025Verified purchase

    Matrixyl Syn 6

    This is my second bottle of Matrixyl Syn 6. I love the thickness of the serum, not too watery. I'm not sure if it's significantly helping but it's not hurting or irritating. I have a pretty solid skin care routine already. I haven't gone through one full bottle yet but ordered another for a back up. I do believe Timeless has good products.
    Cheryl
    effectiveness: 4 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    3 guests found this review helpful. Did you?
    5 out of 5 stars
    21 February, 2025
    originally posted on https://www.timelessha.com/
    Image

    THANK YOU

    MY SKIN IS MORE FIRM AND I LOVE EVERYTHING I'M USING.....A FRIEND OF MINE RECOMMENDED THIS COMPANY AND THE CREAMS.....I LOVE HER RECOMMENDATION.....
    Undisclosed
    Did you find this review helpful?
    5 out of 5 stars
    20 February, 2025
    originally posted on https://www.timelessha.com/
    Image

    Good Stuff

    This serum really hydrates, and it's become a regular part of my routine. I enjoy uusing it as a base part for my monthly microneedling, and I really love the results.
    Undisclosed
    Did you find this review helpful?
    2 out of 5 stars
    Thumbs down graphic, would not recommend
    26 June, 2024Verified purchase

    Ineffective

    Had high hopes for this based on reviews I'd read online. After 2.5 months of daily use around my eyes and on my hands (layered under my regular cerave moisturizing cream), my skin is looking drier and more crepey/wrinkly than ever. I understand peptides are a long game and can take time to have an effect, but I did expect to see some very slight benefit - if nothing else from the added hydration - from a few months of use.
    Anon
    effectiveness: 1 out of 5
    1 guest found this review helpful. Did you?
    3 out of 5 stars
    20 June, 2024

    Decent product that works

    Decent product with a science-backed peptide that's name brand is Matrixyl Synthe 6. Just know there's an "ordinary" brand out there that provides a total of 10% Matrixyl Synthe 6 (palmitoyl tripeptide 38) and Matrixyl 3000 (palmitoyl tripeptide 1 plus palmitoyl tetrapeptide 7) together in one, lower cost product with greater efficacy.
    ToiletPaperAnalyst
    6 guests found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    3 June, 2024Verified purchase

    Love this serum

    Awesome serum for hydration and anti aging
    Stephanie
    quality: 5 out of 5
    value: 5 out of 5
    1 guest found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    18 July, 2023Verified purchase

    Love all Timeless products! ❤️

    It soaks in right away, never greasy. Makes my skin soft and doesn't break me out. I can see a difference in a month of using their products. ( I have 4 different serums and love the sprays as well)
    Aimee
    6 guests found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    31 May, 2023Verified purchase

    Buy

    excellent ingredients
    Memr
    quality: 5 out of 5
    value: 5 out of 5
    effectiveness: 5 out of 5
    2 guests found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    24 May, 2023Verified purchase

    Nighttime serum

    Great product. Happy to be able to order from Target.
    LJB
    value: 5 out of 5
    quality: 5 out of 5
    effectiveness: 5 out of 5
    3 guests found this review helpful. Did you?
    5 out of 5 stars
    15 April, 2023
    originally posted on https://www.timelessha.com/
    Image

    Really like it

    Have used it for many months, and it helps maintain my skin texture.
    Monika M
    Did you find this review helpful?
    2 out of 5 stars
    Thumbs down graphic, would not recommend
    20 March, 2023Verified purchase

    Not great

    I really wanted to like this. Timeless markets heavy on Insta and I fell for it. Their website reviews aren’t real—I wrote a negative thoughtful review for a product that never showed up on the site. Sad. This is very lightweight and feels like water. Unfortunately I’m either allergic to something in it or it’s low quality ingredients. Will not buy again.
    Cocobun
    effectiveness: 2 out of 5
    14 guests found this review helpful. Did you?
    5 out of 5 stars
    Thumbs up graphic, would recommend
    29 December, 2022Verified purchase

    Great serum

    This serum is great! It works for deep wrinkles.
    Nannyk53
    effectiveness: 5 out of 5
    quality: 5 out of 5
    value: 5 out of 5
    4 guests found this review helpful. Did you?

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