Timeless Skin Care Matrixyl Synthe'6 Serum - 1 fl oz: Hydrating, Wrinkle & Fine Line Reduction, for Mature & Dry Skin
$25.99See 1 deal for this item
In Stock
Eligible for registries and wish lists
At a glance
About this item
Additional product information and recommendations
Related Categories
Discover more options
$24.99 - $68.99
Buy 1, get 1 25% off select skincare products
4.5 out of 5 stars with 28 ratings
$25.99 - $74.99
Buy 1, get 1 25% off select skincare products
4.5 out of 5 stars with 127 ratings
$22.99 - $59.99
Buy 1, get 1 25% off select skincare products
3.5 out of 5 stars with 17 ratings
$23.99 - $60.99
Buy 1, get 1 25% off select skincare products
4.9 out of 5 stars with 16 ratings
$11.99
Buy 1, get 1 25% off select skincare products
4 out of 5 stars with 28 ratings
Frequently bought together
Highly rated
$25.99 - $73.99
Buy 1, get 1 25% off select skincare products
4 out of 5 stars with 593 ratings
Bestseller
$9.99($1.82/ounce)
Buy 1, get 1 25% off select skincare products
4.6 out of 5 stars with 4894 ratings
Guests also viewed
Highly rated
$25.99 - $73.99
Buy 1, get 1 25% off select skincare products
4 out of 5 stars with 593 ratings
$25.99 - $68.99
Buy 1, get 1 25% off select skincare products
4.6 out of 5 stars with 70 ratings
$25.99 - $74.99
Buy 1, get 1 25% off select skincare products
4.5 out of 5 stars with 127 ratings
$24.99 - $68.99
Buy 1, get 1 25% off select skincare products
4.5 out of 5 stars with 28 ratings
$11.99
Buy 1, get 1 25% off select skincare products
4 out of 5 stars with 28 ratings
Guests are saying
This product has garnered positive feedback for its hydrating and anti-aging properties, making it a staple in many guests' skincare routines. Users appreciate its lightweight texture, quick absorption, and noticeable improvements in skin texture and appearance. Many guests have reported significant reductions in fine lines and wrinkles, making it a favorite among those seeking effective skincare solutions. Its compatibility with other products enhances its effectiveness, contributing to a youthful glow.
Summary created by AI from text of reviews reflecting recent feedback provided across different star ratings (includes incentivized reviews)
4.6 out of 5 stars with 70 reviews
effectiveness: 4.41 out of 5
quality: 4.88 out of 5
value: 4.81 out of 5
86% would recommend
15 recommendations
5 out of 5 stars
5 February, 2026Verified purchase
(no review title)
I have only been using this new serum for a week, and I have noticed an improvement in my wrinkles.
5 out of 5 stars
Thumbs up graphic, would recommend
1 December, 2025Verified purchase
adds a "snap" to skin
Adds a subtle snap to skin. In the winter or dry climates, be sure to apply to damp skin ad then seal with an occlusive moisturizer since it has hyaluronic acid, which can dry out your skin when the humidity is low.
5 out of 5 stars
Thumbs up graphic, would recommend
29 November, 2025Verified purchase
Love this as a staple in skin care
Great product recommended by Hot and Flashy on you tube! It does its job!
5 out of 5 stars
Thumbs up graphic, would recommend
23 September, 2025Verified purchase
Great skincare product!
The timeless skin care line is an amazing, high quality, line of products that provides great results and makes my skin feel amazing. I use this in conjunction with the Vitamin C+E Ferulic Acid Cerum and the Q10 Serum. Incredibly happy with the results. A very simple, non-fussy routine.
5 out of 5 stars
Thumbs up graphic, would recommend
21 September, 2025Verified purchase
The best.
Perfect hydration, I put this on after toner and I just got a professional facial — she said I had some of the best skin she’d ever seen! Highly recommend. A bottle will last you ~3 months at least.
5 out of 5 stars
20 September, 2025
originally posted on https://www.timelessha.com/

Love it
Fantastic. Use it since 10 years.
5 out of 5 stars
17 September, 2025
originally posted on https://www.timelessha.com/

Love it
Price and quality are unbeatable - my new holy grail!
5 out of 5 stars
1 June, 2025
originally posted on https://www.timelessha.com/

Great new addition
Added this product 3 months ago and notice the biggest difference in my neck. Fine lines are disappearing and my neck is looking younger!
4 out of 5 stars
Thumbs up graphic, would recommend
21 February, 2025Verified purchase
Matrixyl Syn 6
This is my second bottle of Matrixyl Syn 6. I love the thickness of the serum, not too watery. I'm not sure if it's significantly helping but it's not hurting or irritating. I have a pretty solid skin care routine already. I haven't gone through one full bottle yet but ordered another for a back up. I do believe Timeless has good products.
5 out of 5 stars
21 February, 2025
originally posted on https://www.timelessha.com/

THANK YOU
MY SKIN IS MORE FIRM AND I LOVE EVERYTHING I'M USING.....A FRIEND OF MINE RECOMMENDED THIS COMPANY AND THE CREAMS.....I LOVE HER RECOMMENDATION.....
5 out of 5 stars
20 February, 2025
originally posted on https://www.timelessha.com/

Good Stuff
This serum really hydrates, and it's become a regular part of my routine. I enjoy uusing it as a base part for my monthly microneedling, and I really love the results.
2 out of 5 stars
Thumbs down graphic, would not recommend
26 June, 2024Verified purchase
Ineffective
Had high hopes for this based on reviews I'd read online. After 2.5 months of daily use around my eyes and on my hands (layered under my regular cerave moisturizing cream), my skin is looking drier and more crepey/wrinkly than ever. I understand peptides are a long game and can take time to have an effect, but I did expect to see some very slight benefit - if nothing else from the added hydration - from a few months of use.
3 out of 5 stars
20 June, 2024
Decent product that works
Decent product with a science-backed peptide that's name brand is Matrixyl Synthe 6. Just know there's an "ordinary" brand out there that provides a total of 10% Matrixyl Synthe 6 (palmitoyl tripeptide 38) and Matrixyl 3000 (palmitoyl tripeptide 1 plus palmitoyl tetrapeptide 7) together in one, lower cost product with greater efficacy.
5 out of 5 stars
Thumbs up graphic, would recommend
3 June, 2024Verified purchase
Love this serum
Awesome serum for hydration and anti aging
5 out of 5 stars
Thumbs up graphic, would recommend
18 July, 2023Verified purchase
Love all Timeless products! ❤️
It soaks in right away, never greasy. Makes my skin soft and doesn't break me out. I can see a difference in a month of using their products. ( I have 4 different serums and love the sprays as well)
5 out of 5 stars
Thumbs up graphic, would recommend
31 May, 2023Verified purchase
Buy
excellent ingredients
5 out of 5 stars
Thumbs up graphic, would recommend
24 May, 2023Verified purchase
Nighttime serum
Great product. Happy to be able to order from Target.
5 out of 5 stars
15 April, 2023
originally posted on https://www.timelessha.com/

Really like it
Have used it for many months, and it helps maintain my skin texture.
2 out of 5 stars
Thumbs down graphic, would not recommend
20 March, 2023Verified purchase
Not great
I really wanted to like this. Timeless markets heavy on Insta and I fell for it. Their website reviews aren’t real—I wrote a negative thoughtful review for a product that never showed up on the site. Sad. This is very lightweight and feels like water. Unfortunately I’m either allergic to something in it or it’s low quality ingredients. Will not buy again.
5 out of 5 stars
Thumbs up graphic, would recommend
29 December, 2022Verified purchase
Great serum
This serum is great! It works for deep wrinkles.